(Q38379274)

2 September 2017

1 reference

title

Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation (English)

1 reference

2 September 2017

Alexander Scholz

1

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2 September 2017

Karl H Plate

series ordinal

2

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2 September 2017

Yvonne Reiss

series ordinal

3

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2 September 2017

language of work or name

English

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publication date

13 March 2015

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Annals of the New York Academy of Sciences

2 September 2017

published in

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2 September 2017

volume

1347

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2 September 2017

page(s)

45-51

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Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning

2 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietins 3 and 4: diverging gene counterparts in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Tie2 expression and phosphorylation in angiogenic and quiescent adult tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

The Tie-2 ligand angiopoietin-2 destabilizes quiescent endothelium through an internal autocrine loop mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin-2 causes pericyte dropout in the normal retina: evidence for involvement in diabetic retinopathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin signaling in the vasculature

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin-1 protects the adult vasculature against plasma leakage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin-1 ameliorates inflammation-induced vascular leakage and improves functional impairment in a rat model of acute experimental autoimmune encephalomyelitis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Vascular endothelial growth factor-angiopoietin chimera with improved properties for therapeutic angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Circulating angiopoietin-1 and angiopoietin-2 in critically ill patients: development and clinical application of two new immunoassays

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Excess circulating angiopoietin-2 is a strong predictor of mortality in critically ill medical patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Altered expression of angiopoietins and Tie2 endothelium receptor in psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

The role of angiopoietin 2 in hyperoxia-induced acute lung injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin/Tie2 signaling transforms capillaries into venules primed for leukocyte trafficking in airway inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin chemotactic activities on neutrophils are regulated by PI-3K activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin-1 upregulates de novo expression of IL-1β and Il1-Ra, and the exclusive release of Il1-Ra from human neutrophils

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Tie2 signaling cooperates with TNF to promote the pro-inflammatory activation of human macrophages independently of macrophage functional phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Distinct role of macrophages in different tumor microenvironments

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Elusive identities and overlapping phenotypes of proangiogenic myeloid cells in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Cancer-related inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Tumor associated macrophages and neutrophils in tumor progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Modes of resistance to anti-angiogenic therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Targeting the ANG2/TIE2 axis inhibits tumor growth and metastasis by impairing angiogenesis and disabling rebounds of proangiogenic myeloid cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Specifically targeting angiopoietin-2 inhibits angiogenesis, Tie2-expressing monocyte infiltration, and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

G-CSF rescues tumor growth and neo-angiogenesis during liver metastasis under host angiopoietin-2 deficiency.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin-2 promotes inflammatory activation of human macrophages and is essential for murine experimental arthritis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Simultaneous targeting of TNF and Ang2 with a novel bispecific antibody enhances efficacy in an in vivo model of arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Double-antiangiogenic protein DAAP targeting vascular endothelial growth factor A and angiopoietins attenuates collagen-induced arthritis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin-2 in experimental colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin-2 may contribute to multiple organ dysfunction and death in sepsis*

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Regulation of angiopoietin expression by bacterial lipopolysaccharide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin 2 mediates microvascular and hemodynamic alterations in sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

The synthetic tie2 agonist peptide vasculotide protects against vascular leakage and reduces mortality in murine abdominal sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin-2 enhances survival in experimental sepsis induced by multidrug-resistant Pseudomonas aeruginosa.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin 2 stimulates TIE2-expressing monocytes to suppress T cell activation and to promote regulatory T cell expansion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

Angiopoietin-1 elicits pro-inflammatory responses in monocytes and differentiating macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FNYAS.12726

21 January 2018

Identifiers

DOI

10.1111/NYAS.12726

1 reference

2 September 2017

1 reference