(Q38401864)

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Metabolic Modifications in Human Biofluids Suggest the Involvement of Sphingolipid, Antioxidant, and Glutamate Metabolism in Alzheimer's Disease Pathogenesis

scientific article published on 02 April 2015

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scholarly article

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Europe PubMed Central

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2 September 2017

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Europe PubMed Central

Metabolic Modifications in Human Biofluids Suggest the Involvement of Sphingolipid, Antioxidant, and Glutamate Metabolism in Alzheimer's Disease Pathogenesis (English)

1 reference

Europe PubMed Central

PubMed publication ID

2 September 2017

1 reference

based on heuristic

inferred from title

Alzheimer's disease

1 reference

based on heuristic

inferred from title

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25835424%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

author name string

Ben Ellis

1

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25835424%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Stuart G Snowden

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25835424%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

publication date

2 April 2015

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Europe PubMed Central

PubMed publication ID

2 September 2017

Journal of Alzheimer's Disease

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25835424%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

46

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25835424%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

2

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25835424%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

313-327

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25835424%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Epidemiology of Alzheimer disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Forecasting the global burden of Alzheimer’s disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Current concepts in Alzheimer's disease: a multidisciplinary review

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Oligomerization and toxicity of beta-amyloid-42 implicated in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Metabolomics in early Alzheimer's disease: identification of altered plasma sphingolipidome using shotgun lipidomics

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Metabolomic changes in autopsy-confirmed Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Alterations in metabolic pathways and networks in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Application of metabolomics approaches to the study of respiratory diseases

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Metabolomics – the link between genotypes and phenotypes

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Metabolic profiling of Alzheimer's disease brains

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Metabolome in progression to Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Metabolite profiling of Alzheimer's disease cerebrospinal fluid

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Toward a predictive model of Alzheimer's disease progression using capillary electrophoresis-mass spectrometry metabolomics.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Non-invasive evaluation of the GABAergic/glutamatergic system in autistic patients observed by MEGA-editing proton MR spectroscopy using a clinical 3 tesla instrument

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Metabolomics: a novel approach to identify potential diagnostic biomarkers and pathogenesis in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Identification of a new plasma biomarker of Alzheimer's disease using metabolomics technology

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

KEGG: kyoto encyclopedia of genes and genomes

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Cerebrospinal fluid levels of free 3-nitrotyrosine are not elevated in the majority of patients with amyotrophic lateral sclerosis or Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Alterations of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Serial CSF sampling in Alzheimer's disease: specific versus non-specific markers.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Glutamate and other CSF amino acids in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Putative amino acid transmitters in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Amino acids and transaminases activity in ventricular CSF and in brain of normal and Alzheimer patients

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Sphingosine 1-phosphate, a key cell signaling molecule

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Sphingolipid metabolites: members of a new class of lipid second messengers

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Sphingolipid metabolic pathway: an overview of major roles played in human diseases

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Cathepsin D targeted by acid sphingomyelinase-derived ceramide

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Palmitic acid-treated astrocytes induce BACE1 upregulation and accumulation of C-terminal fragment of APP in primary cortical neurons.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Fibrillar amyloid-beta-activated human astroglia kill primary human neurons via neutral sphingomyelinase: implications for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Deregulation of sphingolipid metabolism in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Implication of brain cdc2 and MAP2 kinases in the phosphorylation of tau protein in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Oxidative stress increases expression and activity of BACE in NT2 neurons

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Mitochondria are a direct site of A beta accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Recent evidence regarding a role for Cdk5 dysregulation in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

beta-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Amyloid β-peptide (1-42)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Deletion of vitamin E enhances phenotype of Alzheimer disease model mouse.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: the role of Abeta1-42.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Oxidants, oxidative stress and the biology of ageing

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Oxidative stress, caloric restriction, and aging

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Roles of amyloid beta-peptide-associated oxidative stress and brain protein modifications in the pathogenesis of Alzheimer's disease and mild cognitive impairment

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

The role of glutamate in central nervous system health and disease--a review

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Glutamate transmission and toxicity in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

The glutamatergic system and Alzheimer's disease: therapeutic implications

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Oxidative modification of glutamine synthetase by amyloid beta peptide.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Evidence of glutamatergic denervation and possible abnormal metabolism in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Memantine: a review of its use in moderate to severe Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Memantine in moderate-to-severe Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Memantine in severe dementia: results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine).

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Neuroprotection by memantine against neurodegeneration induced by beta-amyloid(1-40).

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Proposed minimum reporting standards for chemical analysis

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

The endophenotype concept in psychiatry: etymology and strategic intentions

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Astroglial expression of ceramide in Alzheimer's disease brains: a role during neuronal apoptosis.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

A new metabolomic workflow for early detection of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Ratio of 8-hydroxyguanine in intact DNA to free 8-hydroxyguanine is increased in Alzheimer disease ventricular cerebrospinal fluid

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Alzheimer's disease and total plasma aminothiols

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Free amino acid and dipeptide changes in the body fluids from Alzheimer's disease subjects

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Amino acid concentrations in cerebrospinal fluid and plasma in Alzheimer's disease and healthy control subjects.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Amino acid concentrations in cerebrospinal fluid in presenile and senile dementia of Alzheimer type and multi-infarct dementia

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

A proposed metabolic strategy for monitoring disease progression in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-141899

21 January 2018

Identifiers

10.3233/JAD-141899

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25835424%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25835424%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

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