(Q38445486)

3 September 2017

title

Inclusion of an IgG1-Fc spacer abrogates efficacy of CD19 CAR T cells in a xenograft mouse model (English)

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3 September 2017

10

G Gaudernack

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3 September 2017

9

G Kvalheim

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3 September 2017

H Almåsbak

1

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3 September 2017

E Walseng

2

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3 September 2017

A Kristian

3

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3 September 2017

M R Myhre

4

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3 September 2017

E M Suso

5

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3 September 2017

L A Munthe

6

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3 September 2017

J T Andersen

7

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3 September 2017

M Y Wang

8

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3 September 2017

J A Kyte

11

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3 September 2017

publication date

5 February 2015

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3 September 2017

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3 September 2017

volume

22

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3 September 2017

issue

5

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3 September 2017

page(s)

391-403

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Treating B-cell cancer with T cells expressing anti-CD19 chimeric antigen receptors.

3 September 2017

cites work

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T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia

21 January 2018

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CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia

21 January 2018

1 reference

Design and implementation of adoptive therapy with chimeric antigen receptor-modified T cells

21 January 2018

1 reference

Chimeric antigen receptor-modified T cells for acute lymphoid leukemia

21 January 2018

1 reference

B-cell depletion and remissions of malignancy along with cytokine-associated toxicity in a clinical trial of anti-CD19 chimeric-antigen-receptor-transduced T cells

21 January 2018

1 reference

Artificial T-cell receptors

21 January 2018

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CD28 cosignalling does not affect the activation threshold in a chimeric antigen receptor-redirected T-cell attack

21 January 2018

1 reference

Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells

21 January 2018

1 reference

A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells

21 January 2018

1 reference

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

21 January 2018

1 reference

Reassessing target antigens for adoptive T-cell therapy

21 January 2018

1 reference

T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis.

21 January 2018

1 reference

Treatment of metastatic renal cell carcinoma with CAIX CAR-engineered T cells: clinical evaluation and management of on-target toxicity

21 January 2018

1 reference

Cancer regression and neurological toxicity following anti-MAGE-A3 TCR gene therapy

21 January 2018

1 reference

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma.

21 January 2018

1 reference

Immunotherapy with gene-modified T cells: limiting side effects provides new challenges.

21 January 2018

1 reference

Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice

21 January 2018

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Resistance of mature T cells to oncogene transformation

21 January 2018

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Decade-long safety and function of retroviral-modified chimeric antigen receptor T cells

21 January 2018

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Transiently redirected T cells for adoptive transfer.

21 January 2018

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Treatment of advanced leukemia in mice with mRNA engineered T cells

21 January 2018

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Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and CD8+ T cells for use in the adoptive immunotherapy of cancer.

21 January 2018

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Chimeric receptor mRNA transfection as a tool to generate antineoplastic lymphocytes

21 January 2018

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High-efficiency transfection of primary human and mouse T lymphocytes using RNA electroporation

21 January 2018

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Regimen-specific effects of RNA-modified chimeric antigen receptor T cells in mice with advanced leukemia

21 January 2018

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Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies.

21 January 2018

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Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias

21 January 2018

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CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients

21 January 2018

1 reference

Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans

21 January 2018

1 reference

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

21 January 2018

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Costimulation tunes tumor-specific activation of redirected T cells in adoptive immunotherapy

21 January 2018

1 reference

Receptor affinity and extracellular domain modifications affect tumor recognition by ROR1-specific chimeric antigen receptor T cells

21 January 2018

1 reference

Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor

21 January 2018

1 reference

Building better chimeric antigen receptors for adoptive T cell therapy

21 January 2018

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Fc receptor-targeted therapies for the treatment of inflammation, cancer and beyond

21 January 2018

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Crosstalk between human IgG isotypes and murine effector cells

21 January 2018

1 reference

Adoptive immunotherapy with genetically engineered T cells: modification of the IgG1 Fc 'spacer' domain in the extracellular moiety of chimeric antigen receptors avoids 'off-target' activation and unintended initiation of an innate immune response

21 January 2018

1 reference

CD20-specific adoptive immunotherapy for lymphoma using a chimeric antigen receptor with both CD28 and 4-1BB domains: pilot clinical trial results

21 January 2018

1 reference

IL-12 release by engineered T cells expressing chimeric antigen receptors can effectively Muster an antigen-independent macrophage response on tumor cells that have shut down tumor antigen expression

21 January 2018

1 reference

Phosphorothioate cap analogs increase stability and translational efficiency of RNA vaccines in immature dendritic cells and induce superior immune responses in vivo

21 January 2018

1 reference

Protein L: a novel reagent for the detection of chimeric antigen receptor (CAR) expression by flow cytometry

21 January 2018

1 reference

Improved Tet-responsive promoters with minimized background expression

21 January 2018

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Long-term follow-up of hematologic relapse-free survival in a phase 2 study of blinatumomab in patients with MRD in B-lineage ALL

21 January 2018

1 reference

The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens

21 January 2018

1 reference

12 December 2020

The nonsignaling extracellular spacer domain of chimeric antigen receptors is decisive for in vivo antitumor activity.

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12 December 2020

Superior T memory stem cell persistence supports long-lived T cell memory

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12 December 2020

Microbead-assisted retroviral transduction for clinical application

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12 December 2020

Good T cells for bad B cells

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12 December 2020

Novel cellular therapies for leukemia: CAR-modified T cells targeted to the CD19 antigen

1 reference

12 December 2020

Prolonged and increased expression of soluble Fc receptors, IgG and a TCR-Ig fusion protein by transiently transfected adherent 293E cells

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12 December 2020

Identifiers

DOI

10.1038/GT.2015.4

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3 September 2017

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