(Q38511183)

English

A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts

scientific article published on 12 January 2009

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scholarly article

1 reference

Europe PubMed Central

3 September 2017

A systems biological approach suggests that transcriptional feedback regulation by dual-specificity phosphatase 6 shapes extracellular signal-related kinase activity in RAS-transformed fibroblasts (English)

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Europe PubMed Central

3 September 2017

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Europe PubMed Central

3 September 2017

object named as

Stefan Legewie

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8

object named as

Martin Vingron

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Europe PubMed Central

3 September 2017

author name string

Szymon M Kielbasa

3

1 reference

Europe PubMed Central

3 September 2017

Anja Schramme

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Europe PubMed Central

3 September 2017

Oleg Tchernitsa

5

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Europe PubMed Central

3 September 2017

Jana Keil

6

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Europe PubMed Central

3 September 2017

Andrea Solf

7

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Europe PubMed Central

3 September 2017

Reinhold Schäfer

9

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Europe PubMed Central

3 September 2017

Hanspeter Herzel

10

1 reference

Europe PubMed Central

3 September 2017

Christine Sers

11

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Europe PubMed Central

3 September 2017

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publication date

12 January 2009

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Europe PubMed Central

3 September 2017

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Europe PubMed Central

3 September 2017

276

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Europe PubMed Central

3 September 2017

1024-1035

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Europe PubMed Central

3 September 2017

4

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Europe PubMed Central

3 September 2017

MAPK signal specificity: the right place at the right time

1 reference

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The effects of a novel MEK inhibitor PD184161 on MEK-ERK signaling and growth in human liver cancer.

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21 January 2018

Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway

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A spectrum of models of signaling pathways

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Ultrasensitivity in the mitogen-activated protein kinase cascade

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Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate

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Emergent properties of networks of biological signaling pathways

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21 January 2018

A computational study of feedback effects on signal dynamics in a mitogen-activated protein kinase (MAPK) pathway model.

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21 January 2018

FGF induces oscillations of Hes1 expression and Ras/ERK activation.

1 reference

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21 January 2018

Negative feedback regulation of FGF signaling levels by Pyst1/MKP3 in chick embryos.

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MKP3 mediates the cellular response to FGF8 signalling in the vertebrate limb

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Dusp6 (Mkp3) is a negative feedback regulator of FGF-stimulated ERK signaling during mouse development

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21 January 2018

Differential regulation of MAP kinase signalling by dual-specificity protein phosphatases.

1 reference

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21 January 2018

Transcriptional basis of KRAS oncogene-mediated cellular transformation in ovarian epithelial cells

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A genome-wide survey of RAS transformation targets

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21 January 2018

Applied bioinformatics for the identification of regulatory elements

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21 January 2018

Inferring combinatorial regulation of transcription in silico

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21 January 2018

Transcriptional regulation by the MAP kinase signaling cascades

1 reference

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21 January 2018

Dual-specificity MAP kinase phosphatases (MKPs) and cancer

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Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues

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21 January 2018

Creation of human tumour cells with defined genetic elements

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21 January 2018

Trafficking of the ErbB receptors and its influence on signaling

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21 January 2018

Gene expression profiling in RAS oncogene-transformed cell lines and in solid tumors using subtractive suppression hybridization and cDNA arrays.

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21 January 2018

Effects of Ras signaling on gene expression analyzed by customized microarrays

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21 January 2018

Identification of nucleocytoplasmic cycling as a remote sensor in cellular signaling by databased modeling

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21 January 2018

Effects of sequestration on signal transduction cascades.

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21 January 2018

Competing docking interactions can bring about bistability in the MAPK cascade

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21 January 2018

Genome-wide analysis of mRNA decay in resting and activated primary human T lymphocytes

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21 January 2018

Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation

1 reference

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21 January 2018

MAP kinase phosphatase as a locus of flexibility in a mitogen-activated protein kinase signaling network

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21 January 2018

Graded mitogen-activated protein kinase activity precedes switch-like c-Fos induction in mammalian cells.

1 reference

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21 January 2018

Kinetic analysis of platelet-derived growth factor receptor/phosphoinositide 3-kinase/Akt signaling in fibroblasts

1 reference

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21 January 2018

How robust are switches in intracellular signaling cascades?

1 reference

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21 January 2018

Why do protein kinase cascades have more than one level?

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21 January 2018

Defining the mammalian CArGome

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Actin' together: serum response factor, its cofactors and the link to signal transduction

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Transcriptional regulation by the phosphorylation-dependent factor CREB

1 reference

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21 January 2018

Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter

1 reference

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21 January 2018

Recurrent design patterns in the feedback regulation of the mammalian signalling network

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Quantitative analysis of signaling networks.

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Inhibition of gluconeogenesis through transcriptional activation of EGR1 and DUSP4 by AMP-activated kinase

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p204 protein is a novel modulator of ras activity

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Negative feedback predominates over cross-regulation to control ERK MAPK activity in response to FGF signalling in embryos.

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Mkp3 is a negative feedback modulator of Fgf8 signaling in the mammalian isthmic organizer.

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Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer

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Elevated expression of mitogen-activated protein kinase phosphatase 3 in breast tumors: a mechanism of tamoxifen resistance

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A five-gene signature and clinical outcome in non-small-cell lung cancer

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Suppression and re-expression of transformed phenotype in hybrids of HA-ras-1-transformed rat-1 cells and early-passage rat embryonic fibroblasts

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A new mathematical model for relative quantification in real-time RT-PCR

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Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades

1 reference

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21 January 2018

Control of MAPK signalling: from complexity to what really matters

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21 January 2018

Identifiers

10.1111/J.1742-4658.2008.06846.X

1 reference

Europe PubMed Central

3 September 2017

1 reference

Europe PubMed Central

3 September 2017

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