(Q38525578)

3 September 2017

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title

Update on thiopurine pharmacogenetics in inflammatory bowel disease (English)

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inflammatory bowel diseases

3 September 2017

main subject

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publication date

12 June 2015

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3 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26067482%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

volume

16

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26067482%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

issue

8

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26067482%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

page(s)

891-903

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26067482%20AND%20SRC:MED&resulttype=core&format=json

Difficulties and possibilities with thiopurine therapy in inflammatory bowel disease--proceedings of the first Thiopurine Task Force meeting.

13 June 2020

cites work

1 reference

Current relevance of pharmacogenetics in immunomodulation treatment for Crohn's disease

21 January 2018

1 reference

Thiopurine drug adverse effects in a population of New Zealand patients with inflammatory bowel disease.

21 January 2018

1 reference

Optimizing thiopurine therapy: more weight to the metabolite argument

21 January 2018

1 reference

6-MP metabolite profiles provide a biochemical explanation for 6-MP resistance in patients with inflammatory bowel disease.

21 January 2018

1 reference

Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing

21 January 2018

1 reference

Thiopurine dose in intermediate and normal metabolizers of thiopurine methyltransferase may differ three-fold

21 January 2018

1 reference

Genotypic analysis of thiopurine S-methyltransferase in patients with Crohn's disease and severe myelosuppression during azathioprine therapy

21 January 2018

1 reference

Thiopurine methyltransferase genotype predicts therapy-limiting severe toxicity from azathioprine

21 January 2018

1 reference

Relevance of thiopurine methyltransferase activity in inflammatory bowel disease patients maintained on low-dose azathioprine

21 January 2018

1 reference

Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience

21 January 2018

1 reference

Thiopurine S-methyltransferase (TPMT) genotype does not predict adverse drug reactions to thiopurine drugs in patients with inflammatory bowel disease.

21 January 2018

1 reference

Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism

21 January 2018

1 reference

Do the distribution patterns of polymorphisms at the thiopurine S-methyltransferase locus in sub-Saharan populations need revision? Hints from Cabinda and Mozambique

21 January 2018

1 reference

A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia

21 January 2018

1 reference

Transporter-mediated protection against thiopurine-induced hematopoietic toxicity

21 January 2018

1 reference

Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase).

21 January 2018

1 reference

Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease.

21 January 2018

1 reference

Deletion of glutathione-s-transferase m1 reduces azathioprine metabolite concentrations in young patients with inflammatory bowel disease

21 January 2018

1 reference

Genetic variation in the MTHFR gene influences thiopurine methyltransferase activity

21 January 2018

1 reference

IMPDH1 promoter mutations in a patient exhibiting azathioprine resistance.

21 January 2018

1 reference

Evidence for a functional genetic polymorphism of the Rho-GTPase Rac1. Implication in azathioprine response?

21 January 2018

1 reference

Thiopurine effectiveness in patients with Crohn's disease: a study of genetic and clinical predictive factors

21 January 2018

1 reference

HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants.

21 January 2018

1 reference

Nomenclature for alleles of the thiopurine methyltransferase gene

21 January 2018

1 reference

Comprehensive analysis of thiopurine S-methyltransferase phenotype-genotype correlation in a large population of German-Caucasians and identification of novel TPMT variants

21 January 2018

1 reference

Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics

21 January 2018

1 reference

Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation

21 January 2018

1 reference

Adverse reactions to azathioprine cannot be predicted by thiopurine S-methyltransferase genotype in Japanese patients with inflammatory bowel disease

21 January 2018

1 reference

Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: comparison with MTH1 and MTH2

21 January 2018

1 reference

Transport of cyclic nucleotides and estradiol 17-beta-D-glucuronide by multidrug resistance protein 4. Resistance to 6-mercaptopurine and 6-thioguanine

21 January 2018

1 reference

The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease

21 January 2018

1 reference

Individual variation in inosine triphosphate accumulation in human erythrocytes

21 January 2018

1 reference

Human inosine triphosphatase: Catalytic properties and population studies

21 January 2018

1 reference

Genetic basis of inosine triphosphate pyrophosphohydrolase deficiency.

21 January 2018

1 reference

Relationships between nucleoside triphosphate pyrophosphohydrolase activity and inosine triphosphate accumulation in human erythrocytes

21 January 2018

1 reference

DNA polymorphisms in ITPA including basis of inosine triphosphatase deficiency

21 January 2018

1 reference

Lack of association between the ITPA 94C>A polymorphism and adverse effects from azathioprine

21 January 2018

1 reference

Inosine triphosphate pyrophosphatase and thiopurine s-methyltransferase genotypes relationship to azathioprine-induced myelosuppression

21 January 2018

1 reference

Small bowel malignancy at diagnosis of coeliac disease

21 January 2018

1 reference

Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment

21 January 2018

1 reference

Association between adverse effects under azathioprine therapy and inosine triphosphate pyrophosphatase activity in patients with chronic inflammatory bowel disease

21 January 2018

1 reference

Meta-analysis: Inosine triphosphate pyrophosphatase polymorphisms and thiopurine toxicity in the treatment of inflammatory bowel disease.

21 January 2018

1 reference

Association of inosine triphosphatase 94C>A and thiopurine S-methyltransferase deficiency with adverse events and study drop-outs under azathioprine therapy in a prospective Crohn disease study

21 January 2018

1 reference

Pharmacogenetics during standardised initiation of thiopurine treatment in inflammatory bowel disease

21 January 2018

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Enzymatic thiolysis of azathioprine in vitro

21 January 2018

1 reference

Characterization of the human class Mu glutathione S-transferase gene cluster and the GSTM1 deletion

21 January 2018

1 reference

Clinical significance of SOD2 and GSTP1 gene polymorphisms in Chinese patients with gastric cancer

21 January 2018

1 reference

Effect of polymorphism in the human glutathione S-transferase A1 promoter on hepatic GSTA1 and GSTA2 expression

21 January 2018

1 reference

Genetic analysis of glutathione S-transferase A1 polymorphism in the Chinese population and the influence of genotype on enzymatic properties

21 January 2018

1 reference

Functional polymorphism of human glutathione transferase A2.

21 January 2018

1 reference

Pharmacogenetics of azathioprine in inflammatory bowel disease: a role for glutathione-S-transferase?

21 January 2018

1 reference

Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line.

21 January 2018

1 reference

The depletion of nuclear glutathione impairs cell proliferation in 3t3 fibroblasts

21 January 2018

1 reference

Mechanism of azathioprine-induced injury to hepatocytes: roles of glutathione depletion and mitochondrial injury

21 January 2018

1 reference

Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice

21 January 2018

1 reference

Effect of acute hyperhomocysteinemia on methylation potential of erythrocytes and on DNA methylation of lymphocytes in healthy male volunteers

21 January 2018

1 reference

Consequences of binding an S-adenosylmethionine analogue on the structure and dynamics of the thiopurine methyltransferase protein backbone

21 January 2018

1 reference

PACSIN2 polymorphism influences TPMT activity and mercaptopurine-related gastrointestinal toxicity

21 January 2018

1 reference

A comprehensive siRNA screen for kinases that suppress macroautophagy in optimal growth conditions.

21 January 2018

1 reference

The efficacy of azathioprine for the treatment of inflammatory bowel disease: a 30 year review

21 January 2018

1 reference

Thiopurine methyltransferase activity and the use of azathioprine in inflammatory bowel disease

21 January 2018

1 reference

Thiopurine methyltransferase activity influences clinical response to azathioprine in inflammatory bowel disease

21 January 2018

1 reference

High TPMT enzyme activity does not explain drug resistance due to preferential 6-methylmercaptopurine production in patients on thiopurine treatment.

21 January 2018

1 reference

Gene expression and thiopurine metabolite profiling in inflammatory bowel disease - novel clues to drug targets and disease mechanisms?

21 January 2018

1 reference

New genetic biomarkers predicting azathioprine blood concentrations in combination therapy with 5-aminosalicylic acid

21 January 2018

1 reference

Azathioprine suppresses ezrin-radixin-moesin-dependent T cell-APC conjugation through inhibition of Vav guanosine exchange activity on Rac proteins

21 January 2018

1 reference

Safety of thiopurine therapy in inflammatory bowel disease: long-term follow-up study of 3931 patients.

21 January 2018

1 reference

Sequential evaluation of thiopurine methyltransferase, inosine triphosphate pyrophosphatase, and HPRT1 genes polymorphisms to explain thiopurines' toxicity and efficacy

21 January 2018

1 reference

Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.2217/PGS.15.29

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26067482%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference