(Q38528206)

3 September 2017

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title

Autophagy and Lipid Droplets in the Liver (English)

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Gene Ontology release 2020-05-02

3 September 2017

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Nuria Martinez-Lopez

1

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3 September 2017

Rajat Singh

series ordinal

2

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3 September 2017

language of work or name

English

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publication date

6 May 2015

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Annual Review of Nutrition

3 September 2017

published in

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3 September 2017

volume

35

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3 September 2017

page(s)

215-237

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The lipolysis/esterification cycle of hepatic triacylglycerol. Its role in the secretion of very-low-density lipoprotein and its response to hormones and sulphonylureas

3 September 2017

cites work

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12 December 2020

A genetic and structural analysis of the yeast Vps15 protein kinase: evidence for a direct role of Vps15p in vacuolar protein delivery

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12 December 2020

A selective pathway for degradation of cytosolic proteins by lysosomes

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12 December 2020

Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae

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12 December 2020

Roles of the Snf1/Rkin1/AMP-activated protein kinase family in the response to environmental and nutritional stress.

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12 December 2020

Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae

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12 December 2020

Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway

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12 December 2020

AUT1, a gene essential for autophagocytosis in the yeast Saccharomyces cerevisiae

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12 December 2020

Steatohepatitis: a tale of two "hits"?

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12 December 2020

Identification of mouse ULK1, a novel protein kinase structurally related to C. elegans UNC-51

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12 December 2020

Induction of autophagy and inhibition of tumorigenesis by beclin 1

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12 December 2020

Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells.

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12 December 2020

The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3

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12 December 2020

Lipid droplet binding and oligomerization properties of the Parkinson's disease protein alpha-synuclein

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12 December 2020

Modulation of hormone-sensitive lipase and protein kinase A-mediated lipolysis by perilipin A in an adenoviral reconstituted system

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12 December 2020

Non-alcoholic steatohepatitis (NASH): where are we now and where are we going?

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12 December 2020

Electron microscopy of lysosomerich fractions from rat liver

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12 December 2020

HORMONE-SENSITIVE LIPASE AND MONOGLYCERIDE LIPASE ACTIVITIES IN ADIPOSE TISSUE

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12 December 2020

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

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12 December 2020

LC3 conjugation system in mammalian autophagy

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12 December 2020

Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase

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12 December 2020

Diverse polyubiquitin interaction properties of ubiquitin-associated domains

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12 December 2020

Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway

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12 December 2020

A human protein-protein interaction network: a resource for annotating the proteome

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12 December 2020

ADRP/adipophilin is degraded through the proteasome-dependent pathway during regression of lipid-storing cells

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12 December 2020

Perilipin targets a novel pool of lipid droplets for lipolytic attack by hormone-sensitive lipase

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12 December 2020

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

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12 December 2020

Degradation of perilipin is mediated through ubiquitination-proteasome pathway

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12 December 2020

The phosphorylation of serine 492 of perilipin a directs lipid droplet fragmentation and dispersion

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12 December 2020

Chaperone-mediated autophagy in aging and disease

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12 December 2020

p62/SQSTM1: a missing link between protein aggregates and the autophagy machinery

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12 December 2020

Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

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12 December 2020

Atg9 trafficking in Mammalian cells.

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12 December 2020

The crystal structure of Atg3, an autophagy-related ubiquitin carrier protein (E2) enzyme that mediates Atg8 lipidation

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12 December 2020

Selective degradation of mitochondria by mitophagy

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12 December 2020

Regulation of adipocyte lipolysis by degradation of the perilipin protein: nelfinavir enhances lysosome-mediated perilipin proteolysis

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12 December 2020

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

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12 December 2020

Ambra1 regulates autophagy and development of the nervous system

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12 December 2020

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity

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12 December 2020

Cell cycle-dependent induction of autophagy, mitophagy and reticulophagy

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12 December 2020

The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy

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12 December 2020

Hepatitis C Virus Genotype 1a Growth and Induction of Autophagy

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12 December 2020

The ATG12-conjugating enzyme ATG10 Is essential for autophagic vesicle formation in Arabidopsis thaliana

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12 December 2020

Hepatic overexpression of hormone-sensitive lipase and adipose triglyceride lipase promotes fatty acid oxidation, stimulates direct release of free fatty acids, and ameliorates steatosis

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12 December 2020

Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease

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12 December 2020

JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy

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12 December 2020

Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

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12 December 2020

Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG

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12 December 2020

Lipid droplets and hepatitis C virus infection

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12 December 2020

The MAP1-LC3 conjugation system is involved in lipid droplet formation

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12 December 2020

Autophagy regulates lipid metabolism

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12 December 2020

Lipases in lysosomes, what for?

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12 December 2020

Adoption of PERILIPIN as a unifying nomenclature for the mammalian PAT-family of intracellular lipid storage droplet proteins

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12 December 2020

Regulation mechanisms and signaling pathways of autophagy

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12 December 2020

The autophagy machinery is required to initiate hepatitis C virus replication

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12 December 2020

The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria

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12 December 2020

3D tomography reveals connections between the phagophore and endoplasmic reticulum

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12 December 2020

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

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12 December 2020

Lysosomal enhancement: a CLEAR answer to cellular degradative needs

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12 December 2020

The conserved oligomeric Golgi complex is involved in double-membrane vesicle formation during autophagy

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12 December 2020

The early autophagic pathway is activated by hepatitis B virus and required for viral DNA replication

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12 December 2020

Altered lipid content inhibits autophagic vesicular fusion

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12 December 2020

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

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12 December 2020

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

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12 December 2020

Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation

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12 December 2020

Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance.

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12 December 2020

Macroautophagy and chaperone-mediated autophagy are required for hepatocyte resistance to oxidant stress

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12 December 2020

Plasma membrane contributes to the formation of pre-autophagosomal structures

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12 December 2020

Inhibitory effect of intracellular lipid load on macroautophagy

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12 December 2020

The origin of the autophagosomal membrane

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12 December 2020

Macroautophagy regulates energy metabolism during effector T cell activation

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12 December 2020

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12 December 2020

Ancient ubiquitous protein 1 (AUP1) localizes to lipid droplets and binds the E2 ubiquitin conjugase G2 (Ube2g2) via its G2 binding region

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12 December 2020

Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy

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12 December 2020

Microautophagy of cytosolic proteins by late endosomes

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12 December 2020

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

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12 December 2020

Chasing the elusive mammalian microautophagy

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12 December 2020

Autophagosome targeting and membrane curvature sensing by Barkor/Atg14(L).

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12 December 2020

Autophagy in the cellular energetic balance

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12 December 2020

TFEB links autophagy to lysosomal biogenesis

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12 December 2020

Phosphorylation of the autophagy receptor optineurin restricts Salmonella growth

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12 December 2020

The role of lipid droplets in metabolic disease in rodents and humans

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12 December 2020

Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase

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12 December 2020

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways.

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12 December 2020

SNARE proteins are required for macroautophagy

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12 December 2020

A role for autophagy during hepatic stellate cell activation

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12 December 2020

Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance

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12 December 2020

Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans

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12 December 2020

The puzzling origin of the autophagosomal membrane

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12 December 2020

Regulation of lipid droplet cholesterol efflux from macrophage foam cells

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12 December 2020

Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues.

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12 December 2020

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

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12 December 2020

Mapping autophagy on to your metabolic radar

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12 December 2020

Autophagy regulates lipolysis and cell survival through lipid droplet degradation in androgen-sensitive prostate cancer cells

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12 December 2020

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

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12 December 2020

Autophagy-lysosomal pathway is involved in lipid degradation in rat liver.

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12 December 2020

Autophagy modulates dynamics of connexins at the plasma membrane in a ubiquitin-dependent manner

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12 December 2020

Tightrope act: autophagy in stem cell renewal, differentiation, proliferation, and aging.

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12 December 2020

Autophagy inhibition due to thymidine analogues as novel mechanism leading to hepatocyte dysfunction and lipid accumulation.

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12 December 2020

AMPK-dependent phosphorylation of ULK1 regulates ATG9 localization

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12 December 2020

Guidelines for the use and interpretation of assays for monitoring autophagy

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12 December 2020

The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism

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12 December 2020

Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation

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12 December 2020

Autophagy as a stress-response and quality-control mechanism: implications for cell injury and human disease

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12 December 2020

Oligonol-induced degradation of perilipin 1 is regulated through lysosomal degradation machinery

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12 December 2020

Effect of short- and long-term high-fat feeding on autophagy flux and lysosomal activity in rat liver

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12 December 2020

The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes

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12 December 2020

NBR1 acts as an autophagy receptor for peroxisomes

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12 December 2020

Deciphering the contribution of lipid droplets in leprosy: multifunctional organelles with roles in Mycobacterium leprae pathogenesis

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12 December 2020

Pharmacological promotion of autophagy alleviates steatosis and injury in alcoholic and non-alcoholic fatty liver conditions in mice

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12 December 2020

Autophagy in human health and disease

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12 December 2020

Autophagosomes form at ER-mitochondria contact sites

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12 December 2020

Inhibition of hepatocyte autophagy increases tumor necrosis factor-dependent liver injury by promoting caspase-8 activation

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12 December 2020

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.

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12 December 2020

MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability

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12 December 2020

TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

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12 December 2020

Immunohistochemical study of the autophagy marker microtubule-associated protein 1 light chain 3 in normal and steatotic human livers

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12 December 2020

Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice.

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12 December 2020

Lipid droplet metabolism

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12 December 2020

FoxO1 controls lysosomal acid lipase in adipocytes: implication of lipophagy during nutrient restriction and metformin treatment

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12 December 2020

Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes.

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12 December 2020

Autophagosomes contribute to intracellular lipid distribution in enterocytes

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12 December 2020

Liver autophagy: much more than just taking out the trash

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12 December 2020

The Interplay between Autophagy and Aging

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12 December 2020

Lipid droplet autophagy in the yeast Saccharomyces cerevisiae

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12 December 2020

Chaperone-mediated autophagy: roles in disease and aging

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12 December 2020

Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease

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12 December 2020

Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation

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12 December 2020

Lysosomal multienzyme complex: pros and cons of working together

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12 December 2020

Historical landmarks of autophagy research

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12 December 2020

Detection of WIPI1 mRNA as an indicator of autophagosome formation

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12 December 2020

Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance.

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12 December 2020

Neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis

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12 December 2020

The emerging role of autophagy in peroxisome dynamics and lipid metabolism of phyllosphere microorganisms.

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12 December 2020

OsATG7 is required for autophagy-dependent lipid metabolism in rice postmeiotic anther development

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12 December 2020

Connexins modulate autophagosome biogenesis

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12 December 2020

Lipid droplet biogenesis

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12 December 2020

Lipidation of the LC3/GABARAP family of autophagy proteins relies on a membrane-curvature-sensing domain in Atg3.

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12 December 2020

A sterol-enriched vacuolar microdomain mediates stationary phase lipophagy in budding yeast

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12 December 2020

Pharmacological correction of obesity-induced autophagy arrest using calcium channel blockers

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12 December 2020

Impairment of autophagosome-lysosome fusion contributes to chronic ethanol-induced liver injury

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12 December 2020

Autophagy regulates sphingolipid levels in the liver

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12 December 2020

Transcriptional regulation of autophagy by an FXR-CREB axis

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12 December 2020

Nutrient-sensing nuclear receptors coordinate autophagy

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12 December 2020

Bulk RNA degradation by nitrogen starvation-induced autophagy in yeast

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12 December 2020

Autophagy mediates nonselective RNA degradation in starving yeast

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12 December 2020

Hepatitis C virus and lipid droplets: finding a niche

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12 December 2020

10.1146/ANNUREV-NUTR-071813-105336

Identifiers

DOI

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3 September 2017

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