(Q36510519)

14 August 2017

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title

Chaperone-mediated autophagy in aging and disease (English)

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14 August 2017

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3

Ana Maria Cuervo

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author name string

Ashish C Massey

series ordinal

1

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PubMed ID

16782460

14 August 2017

Cong Zhang

series ordinal

2

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14 August 2017

1 January 2006

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Current Topics in Developmental Biology

14 August 2017

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14 August 2017

73

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14 August 2017

205-235

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An intralysosomal hsp70 is required for a selective pathway of lysosomal protein degradation

14 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Uptake--microautophagy--and degradation of exogenous proteins by isolated rat liver lysosomes. Effects of pH, ATP, and inhibitors of proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Major histocompatibility complex class II-dependent unfolding, transport, and degradation of endogenous proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Regulation of catabolism of microinjected ribonuclease A requires the amino-terminal 20 amino acids

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Excessive degradation of intracellular protein in macrophages prevents presentation in the context of major histocompatibility complex class II molecules

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Nitric oxide, oxidative stress, and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Exposure of cells to nonlethal concentrations of hydrogen peroxide induces degeneration-repair mechanisms involving lysosomal destabilization

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

A receptor for the selective uptake and degradation of proteins by lysosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Regulation of lamp2a levels in the lysosomal membrane

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

A population of rat liver lysosomes responsible for the selective uptake and degradation of cytosolic proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Direct lysosomal uptake of alpha 2-microglobulin contributes to chemically induced nephropathy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

IkappaB is a substrate for a selective pathway of lysosomal proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Activation of a selective pathway of lysosomal proteolysis in rat liver by prolonged starvation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Degradation of proteasomes by lysosomes in rat liver.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Autophagy: in sickness and in health

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Autophagy: many paths to the same end.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Autophagy and aging: the importance of maintaining "clean" cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Cathepsin A regulates chaperone-mediated autophagy through cleavage of the lysosomal receptor

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Batten's disease: clues to neuronal protein catabolism in lysosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Functions of lysosomes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Autophagy promotes MHC class II presentation of peptides from intracellular source proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Peptide sequences that target cytosolic proteins for lysosomal proteolysis

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Characterization of chronic low-level proteasome inhibition on neural homeostasis.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Role of LAMP-2 in lysosome biogenesis and autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Disturbed cholesterol traffic but normal proteolytic function in LAMP-1/LAMP-2 double-deficient fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Ketone bodies stimulate chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

A mechanism regulating proteolysis of specific proteins during renal tubular cell growth

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Protein degradation and protection against misfolded or damaged proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

The family of LAMP-2 proteins arises by alternative splicing from a single gene: characterization of the avian LAMP-2 gene and identification of mammalian homologs of LAMP-2b and LAMP-2c

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Molecular wear and tear leads to terminal marking and the unstable isoforms of aging

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Selective degradation of oxidatively modified protein substrates by the proteasome.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

An ubiquitin ligase recognizing a protein oxidized by iron: implications for the turnover of oxidatively damaged proteins.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

An endogenous processing pathway in vaccinia virus-infected cells for presentation of cytoplasmic antigens to class II-restricted T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

On the mammalian acetone metabolism: from chemistry to clinical implications

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Decreased levels of proteasome activity and proteasome expression in aging spinal cord

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Activation of chaperone-mediated autophagy during oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

The molecular machinery of autophagy: unanswered questions

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

A Unified Nomenclature for Yeast Autophagy-Related Genes

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Oxidation of biological systems: oxidative stress phenomena, antioxidants, redox reactions, and methods for their quantification

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

The endogenous pathway of MHC class II antigen presentation.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Hyaline droplet nephropathy resulting from exposure to 3,5,5-trimethylhexanoyloxybenzene sulfonate

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Development by self-digestion: molecular mechanisms and biological functions of autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Induction of autophagy and inhibition of tumorigenesis by beclin 1

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Biosynthesis of lysosomal proteinases in health and disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Mechanisms of chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Processing pathways for presentation of cytosolic antigen to MHC class II-restricted T cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Protein degradation and aging

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Pathophysiology of chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Consequences of the selective blockage of chaperone-mediated autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Erythrocyte-mediated microinjection, a technique to study protein degradation in muscle cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Autophagosome formation in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

The ubiquitin-proteasome pathway and proteasome inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Lysosomal storage diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Major histocompatibility complex class II-restricted presentation of a cytosolic antigen by autophagy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

The endosomal-lysosomal system of neurons in Alzheimer's disease pathogenesis: a review

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Cellular injury induced by oxidative stress is mediated through lysosomal damage.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Endogenous MHC class II processing of a viral nuclear antigen after autophagy.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Mechanisms of MHC class I--restricted antigen processing

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Proteasomes and their kin: proteases in the machine age

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Quantitating protein synthesis, degradation, and endogenous antigen processing

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Autophagy regulates the processing of amino terminal huntingtin fragments

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

MHC molecules as peptide receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Disease model: LAMP-2 enlightens Danon disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Autophagy in health and disease: a double-edged sword

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Protein oxidation and 20S proteasome-dependent proteolysis in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Ubiquitin conjugation is not required for the degradation of oxidized proteins by proteasome.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Suppression of chaperone-mediated autophagy in the renal cortex during acute diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

The proteasome and its function in the ageing process.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Comparison of the oxidation of glutamine, glucose, ketone bodies and fatty acids by human diploid fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Transport of human lysosomal neuraminidase to mature lysosomes requires protective protein/cathepsin A.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Presentation of antigens by MHC class II molecules: getting the most out of them

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

MHC class II-restricted presentation of intracellular antigen

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Lysosomal storage disorders: diagnostic dilemmas and prospects for therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Proteins containing peptide sequences related to Lys-Phe-Glu-Arg-Gln are selectively depleted in liver and heart, but not skeletal muscle, of fasted rats

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Diversity in the mechanisms of neuronal cell death.

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

Lamp-2a facilitates MHC class II presentation of cytoplasmic antigens

1 reference

https://api.crossref.org/works/10.1016%2FS0070-2153%2805%2973007-6

7 January 2021

10.1016/S0070-2153(05)73007-6

Identifiers

DOI

1 reference

14 August 2017

1 reference

PubMed ID

16782460