(Q38579541)

4 September 2017

title

LINE-1 in cancer: multifaceted functions and potential clinical implications (English)

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4 September 2017

Lu Xiao-Jie

1

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4 September 2017

Xue Hui-Ying

2

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4 September 2017

Xiaolong Qi

3

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4 September 2017

Xu Jiang

4

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4 September 2017

Ma Shi-Jie

5

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4 September 2017

language of work or name

English

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publication date

3 September 2015

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4 September 2017

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4 September 2017

volume

18

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4 September 2017

issue

5

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4 September 2017

page(s)

431-439

1 reference

https://scigraph.springernature.com/pub.10.1038/gim.2015.119

4 September 2017

exact match

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cites work

Initial sequencing and analysis of the human genome

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Hot L1s account for the bulk of retrotransposition in the human population

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Retroelements in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

A systematic analysis of LINE-1 endonuclease-dependent retrotranspositional events causing human genetic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Isolation of an active human transposable element

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Identification, characterization, and cell specificity of a human LINE-1 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Antisense promoter of human L1 retrotransposon drives transcription of adjacent cellular genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Expression of a large LINE-1-driven antisense RNA is linked to epigenetic silencing of the metastasis suppressor gene TFPI-2 in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Human L1 retrotransposition: cis preference versus trans complementation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Cis-preferential LINE-1 reverse transcriptase activity in ribonucleoprotein particles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Reverse transcription of R2Bm RNA is primed by a nick at the chromosomal target site: a mechanism for non-LTR retrotransposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

DNA repair mediated by endonuclease-independent LINE-1 retrotransposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Alu elements: an intrinsic source of human genome instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Functional impact of the human mobilome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

The non-autonomous retrotransposon SVA is trans-mobilized by the human LINE-1 protein machinery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Processed pseudogenes acquired somatically during cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

A potential role for RNA interference in controlling the activity of the human LINE-1 retrotransposon

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Transcriptional silencing of transposons by Piwi and maelstrom and its impact on chromatin state and gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

The distribution of a germline methylation marker suggests a regional mechanism of LINE-1 silencing by the piRNA-PIWI system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

piRNA pathway targets active LINE1 elements to establish the repressive H3K9me3 mark in germ cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

APOBEC3G inhibits microRNA-mediated repression of translation by interfering with the interaction between Argonaute-2 and MOV10

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Intrinsic restriction activity by AID/APOBEC family of enzymes against the mobility of retroelements

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Evidence consistent with human L1 retrotransposition in maternal meiosis I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

L1 retrotransposition can occur early in human embryonic development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Long interspersed element-1 protein expression is a hallmark of many human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

DNA methylome profiling identifies novel methylated genes in African American patients with colorectal neoplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Increased expression and copy number amplification of LINE-1 and SINE B1 retrotransposable elements in murine mammary carcinoma progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

LINE-1 hypomethylation is associated with a poor prognosis among patients with curatively resected esophageal squamous cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Landscape of somatic retrotransposition in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Insertional mutagenesis of the myc locus by a LINE-1 sequence in a human breast carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Hypomethylation of long interspersed nuclear element-1 (LINE-1) leads to activation of proto-oncogenes in human colorectal cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Genetic and epigenetic changes in fibrosis-associated hepatocarcinogenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Global DNA methylation and one-carbon metabolism gene polymorphisms and the risk of breast cancer in the Sister Study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Prospective study of family history and colorectal cancer risk by tumor LINE-1 methylation level

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

DNA demethylation in normal colon tissue predicts predisposition to multiple cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Tumor LINE-1 methylation level and microsatellite instability in relation to colorectal cancer prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Hypomethylation of long interspersed nuclear element-1 (LINE-1) is associated with poor prognosis via activation of c-MET in hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

LINE-1 hypomethylation in gastric cancer, detected by bisulfite pyrosequencing, is associated with poor prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

The prognostic value of global DNA hypomethylation in cancer: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

LINE1 and Alu repetitive element DNA methylation in tumors and white blood cells from epithelial ovarian cancer patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Association between hypermethylation of DNA repetitive elements in white blood cell DNA and early-onset colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

AIM1 and LINE-1 epigenetic aberrations in tumor and serum relate to melanoma progression and disease outcome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Evaluation of serum LINE-1 hypomethylation as a prognostic marker for hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Repetitive element DNA methylation levels in white blood cell DNA from sisters discordant for breast cancer from the New York site of the Breast Cancer Family Registry

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Examination of whole blood DNA methylation as a potential risk marker for gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Blood leukocyte Alu and LINE-1 methylation and gastric cancer risk in the Shanghai Women's Health Study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Intronic L1 retrotransposons and nested genes cause transcriptional interference by inducing intron retention, exonization and cryptic polyadenylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Genes associated with the cis-regulatory functions of intragenic LINE-1 elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Genomic rearrangements by LINE-1 insertion-mediated deletion in the human and chimpanzee lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Multiple fates of L1 retrotransposition intermediates in cultured human cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Pseudogene in cancer: real functions and promising signature

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Exon shuffling by L1 retrotransposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

LINE-1 activity in facultative heterochromatin formation during X chromosome inactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Reprogramming of the HepG2 genome by long interspersed nuclear element-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Functional microRNAs and target sites are created by lineage-specific transposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Transposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Competing endogenous RNA interplay in cancer: mechanism, methodology, and perspectives

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

A tumor-promoting mechanism mediated by retrotransposon-encoded reverse transcriptase is active in human transformed cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Viral-human chimeric transcript predisposes risk to liver cancer development and progression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

The role of KLF6 and its splice variants in cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Alternative splicing in cancer: implications for biology and therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Prognostic value of LINE-1 retrotransposon expression and its subcellular localization in breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

L1-ORF1p, a Smad4 interaction protein, promotes proliferation of HepG2 cells and tumorigenesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

LINE-1 ORF-1p functions as a novel HGF/ETS-1 signaling pathway co-activator and promotes the growth of MDA-MB-231 cell

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Long interspersed nucleotide acid element-1 ORF-1 protein promotes proliferation and invasion of human colorectal cancer LoVo cells through enhancing ETS-1 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

The reverse transcription inhibitor abacavir shows anticancer activity in prostate cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Inhibition of LINE-1 retrotransposon-encoded reverse transcriptase modulates the expression of cell differentiation genes in breast cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

A phase II trial evaluating the efficacy and safety of efavirenz in metastatic castration-resistant prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

LINE-1 retrotransposition in human neuroblastoma cells is affected by oxidative stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Interleukin-6 promotes tumorigenesis by altering DNA methylation in oral cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Tumor TP53 expression status, body mass index and prognosis in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

DNA damage in inflammation-related carcinogenesis and cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Differences in LINE-1 methylation between endometriotic ovarian cyst and endometriosis-associated ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Multiplatform analysis of 12 cancer types reveals molecular classification within and across tissues of origin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Association between hypermethylation of DNA repetitive elements in white blood cell DNA and pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FGIM.2015.119

Line-1 hypomethylation in multistage carcinogenesis of the uterine cervix.

21 January 2018

1 reference

12 December 2020

Disruption of the APC gene by a retrotransposal insertion of L1 sequence in a colon cancer

1 reference

12 December 2020

APOBEC3A deaminates transiently exposed single-strand DNA during LINE-1 retrotransposition

1 reference

12 December 2020

Oxidative stress induces hypomethylation of LINE-1 and hypermethylation of the RUNX3 promoter in a bladder cancer cell line

1 reference

12 December 2020

Identifiers

DOI

10.1038/GIM.2015.119

1 reference

4 September 2017

1 reference