(Q38608340)

4 September 2017

Immunological hallmarks of stromal cells in the tumour microenvironment (English)

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4 September 2017

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Shannon J Turley

1

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PubMed ID

26471778

4 September 2017

Viviana Cremasco

series ordinal

2

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PubMed ID

26471778

4 September 2017

Jillian L Astarita

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3

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4 September 2017

16 October 2015

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Nature Reviews Immunology

4 September 2017

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4 September 2017

15

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4 September 2017

11

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4 September 2017

669-682

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Microenvironmental regulation of metastasis

4 September 2017

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Co-evolution of tumor cells and their microenvironment

31 March 2020

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Imaging tumor-stroma interactions during chemotherapy reveals contributions of the microenvironment to resistance

31 March 2020

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Oncology meets immunology: the cancer-immunity cycle

31 March 2020

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Tumor immune escape by the loss of homeostatic chemokine expression.

31 March 2020

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MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer

31 March 2020

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Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

31 March 2020

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PD-1 blockade induces responses by inhibiting adaptive immune resistance

31 March 2020

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VEGF-A and the induction of pathological angiogenesis

31 March 2020

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Molecular regulation of vessel maturation

31 March 2020

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A role for VEGF as a negative regulator of pericyte function and vessel maturation

31 March 2020

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Expression of regulator of G protein signalling protein 5 (RGS5) in the tumour vasculature of human renal cell carcinoma.

31 March 2020

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Vascular normalization in Rgs5-deficient tumours promotes immune destruction

31 March 2020

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Normalization of the vasculature for treatment of cancer and other diseases

31 March 2020

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Effects of vascular endothelial growth factor on the lymphocyte-endothelium interactions: identification of caveolin-1 and nitric oxide as control points of endothelial cell anergy

31 March 2020

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Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy.

31 March 2020

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Egfl7 promotes tumor escape from immunity by repressing endothelial cell activation

31 March 2020

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Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium.

31 March 2020

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Role of tumor endothelium in CD4+ CD25+ regulatory T cell infiltration of human pancreatic carcinoma.

31 March 2020

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CD99 plays a major role in the migration of monocytes through endothelial junctions

31 March 2020

1 reference

History of myeloid-derived suppressor cells

31 March 2020

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Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake

31 March 2020

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Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model

31 March 2020

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Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues.

31 March 2020

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Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling

31 March 2020

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Targeting CXCL12 from FAP-expressing carcinoma-associated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

31 March 2020

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Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts

31 March 2020

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Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy

31 March 2020

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31 March 2020

Fibroblasts in cancer

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Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors

31 March 2020

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Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

31 March 2020

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Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

31 March 2020

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Heparanase promotes tumor infiltration and antitumor activity of CAR-redirected T lymphocytes.

31 March 2020

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Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival

31 March 2020

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Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma

31 March 2020

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Cross-primed CD8(+) T cells mediate graft rejection via a distinct effector pathway

31 March 2020

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Presentation of antigen by endothelial cells and chemoattraction are required for homing of insulin-specific CD8+ T cells.

31 March 2020

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Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas

31 March 2020

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Endothelial expression of PD‐L1 and PD‐L2 down‐regulates CD8+ T cell activation and cytolysis

31 March 2020

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B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis

31 March 2020

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Lymphoma endothelium preferentially expresses Tim-3 and facilitates the progression of lymphoma by mediating immune evasion

31 March 2020

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Genes that distinguish physiological and pathological angiogenesis

31 March 2020

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Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance

31 March 2020

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The Puzzling Role of TRAIL in Endothelial Cell Biology

31 March 2020

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Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

31 March 2020

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Secretion of vascular endothelial growth factor by oral squamous cell carcinoma cells skews endothelial cells to suppress T-cell functions

31 March 2020

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Tumors induce the formation of suppressor endothelial cells in vivo

31 March 2020

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Tumor cells induce COX-2 and mPGES-1 expression in microvascular endothelial cells mainly by means of IL-1 receptor activation.

31 March 2020

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Indoleamine 2,3-dioxygenase and tumor-induced tolerance

31 March 2020

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Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase

31 March 2020

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VEGF-C promotes immune tolerance in B16 melanomas and cross-presentation of tumor antigen by lymph node lymphatics

31 March 2020

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Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation

31 March 2020

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Antigen capture and archiving by lymphatic endothelial cells following vaccination or viral infection

31 March 2020

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Lymphatic and interstitial flow in the tumour microenvironment: linking mechanobiology with immunity

31 March 2020

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Interstitial fluid flow induces myofibroblast differentiation and collagen alignment in vitro.

31 March 2020

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Myofibroblast contraction activates latent TGF-beta1 from the extracellular matrix

31 March 2020

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In vitro and in vivo evidence for shear-induced activation of latent transforming growth factor-beta1.

31 March 2020

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Immune tolerance: what is unique about the liver

31 March 2020

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Hepatic stellate cells function as regulatory bystanders

31 March 2020

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Murine hepatic stellate cells veto CD8 T cell activation by a CD54-dependent mechanism.

31 March 2020

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Activated hepatic stellate cells promote hepatocellular carcinoma development in immunocompetent mice

31 March 2020

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Hepatic stellate cells promote tumor progression by enhancement of immunosuppressive cells in an orthotopic liver tumor mouse model

31 March 2020

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PDGFRβ signaling regulates mural cell plasticity and inhibits fat development.

31 March 2020

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Immature mesenchymal stem cell-like pericytes as mediators of immunosuppression in human malignant glioma

31 March 2020

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Tumor-derived vascular pericytes anergize Th cells

31 March 2020

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Lineage tracing and genetic ablation of ADAM12(+) perivascular cells identify a major source of profibrotic cells during acute tissue injury

31 March 2020

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Immunosuppressive effect of mesenchymal stem cells favors tumor growth in allogeneic animals

31 March 2020

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In vitro evidence of the presence of mesenchymal stromal cells in cervical cancer and their role in protecting cancer cells from cytotoxic T cell activity.

31 March 2020

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Immunosuppressive effect of bone marrow-derived mesenchymal stem cells in inflammatory microenvironment favours the growth of B16 melanoma cells

31 March 2020

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Paracrine mechanisms in adult stem cell signaling and therapy

31 March 2020

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TGF beta inhibition for cancer therapy

31 March 2020

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TGF-beta 1 attenuates the acquisition and expression of effector function by tumor antigen-specific human memory CD8 T cells

31 March 2020

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Membrane-associated TGF-beta1 inhibits human memory T cell signaling in malignant and nonmalignant inflammatory microenvironments

31 March 2020

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TGFbeta is responsible for skin tumour infiltration by macrophages enabling the tumours to escape immune destruction

31 March 2020

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Melanoma-associated fibroblasts modulate NK cell phenotype and antitumor cytotoxicity

31 March 2020

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Colorectal carcinoma-derived fibroblasts modulate natural killer cell phenotype and antitumor cytotoxicity.

31 March 2020

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Intratumor T helper type 2 cell infiltrate correlates with cancer-associated fibroblast thymic stromal lymphopoietin production and reduced survival in pancreatic cancer

31 March 2020

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Tumour-associated fibroblasts and mesenchymal stem cells: more similarities than differences

31 March 2020

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The role of myofibroblasts in upregulation of S100A8 and S100A9 and the differentiation of myeloid cells in the colorectal cancer microenvironment

31 March 2020

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Suppression of antitumor immunity by stromal cells expressing fibroblast activation protein-alpha

31 March 2020

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Targeting fibroblast activation protein in tumor stroma with chimeric antigen receptor T cells can inhibit tumor growth and augment host immunity without severe toxicity

31 March 2020

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Tenascin-C inhibits beta1 integrin-dependent T lymphocyte adhesion to fibronectin through the binding of its fnIII 1-5 repeats to fibronectin

31 March 2020

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Tenascin, an extracellular matrix protein, exerts immunomodulatory activities

31 March 2020

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CD47 ligation selectively downregulates human interleukin 12 production

31 March 2020

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CD47 engagement inhibits cytokine production and maturation of human dendritic cells

31 March 2020

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Costimulation of T cell activation by integrin-associated protein (CD47) is an adhesion-dependent, CD28-independent signaling pathway

31 March 2020

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Central role of thrombospondin-1 in the activation and clonal expansion of inflammatory T cells.

31 March 2020

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Role of CD47 in the induction of human naive T cell anergy

31 March 2020

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Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior

31 March 2020

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Matrix metalloproteinases as modulators of inflammation and innate immunity

31 March 2020

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Neutralizing tumor-promoting chronic inflammation: a magic bullet?

31 March 2020

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Tumor-associated macrophage infiltration in pulmonary adenocarcinoma: association with angiogenesis and poor prognosis

31 March 2020

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Macrophages regulate the angiogenic switch in a mouse model of breast cancer

31 March 2020

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Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis

31 March 2020

1 reference

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

31 March 2020

1 reference

Bv8 regulates myeloid-cell-dependent tumour angiogenesis

31 March 2020

1 reference

Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis

31 March 2020

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Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis

31 March 2020

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Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors

31 March 2020

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Mast-cell-deficient W/Wv mice exhibit a decreased rate of tumor angiogenesis

31 March 2020

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Eosinophils: 'new' roles for 'old' cells

31 March 2020

1 reference

Myeloid cells and lymphangiogenesis

31 March 2020

1 reference

Smoldering and polarized inflammation in the initiation and promotion of malignant disease

31 March 2020

1 reference

Tumor-associated macrophages: from mechanisms to therapy

31 March 2020

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CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans

31 March 2020

1 reference

Role of IL-13 in regulation of anti-tumor immunity and tumor growth

31 March 2020

1 reference

B-cell-derived lymphotoxin promotes castration-resistant prostate cancer

31 March 2020

1 reference

Lymphotoxin/light, lymphoid microenvironments and autoimmune disease

31 March 2020

1 reference

Efficacy of CAR T-cell therapy in large tumors relies upon stromal targeting by IFNγ.

31 March 2020

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Focus on lymphangiogenesis in tumor metastasis.

31 March 2020

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A decrease of regulatory T cells correlates with overall survival after sunitinib-based antiangiogenic therapy in metastatic renal cancer patients

31 March 2020

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Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients

31 March 2020

1 reference

Friends or foes - bipolar effects of the tumour stroma in cancer

31 March 2020

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Identification of fibroblast heterogeneity in the tumor microenvironment

31 March 2020

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Clinical implications of fibroblast activation protein in patients with colon cancer

31 March 2020

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Stromal myofibroblasts predict disease recurrence for colorectal cancer

31 March 2020

1 reference

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

31 March 2020

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Endothelial-pericyte interactions in angiogenesis.

31 March 2020

1 reference

Cancer immunotherapy targeting the high molecular weight melanoma-associated antigen protein results in a broad antitumor response and reduction of pericytes in the tumor vasculature

31 March 2020

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Role of lymphatic vessels in tumor immunity: passive conduits or active participants?

31 March 2020

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The pancreas cancer microenvironment

31 March 2020

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Stromal fibroblasts in cancer initiation and progression

31 March 2020

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Head and neck squamous cancer stromal fibroblasts produce growth factors influencing phenotype of normal human keratinocytes

31 March 2020

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Peripheral lymph node stromal cells can promote growth and tumorigenicity of breast carcinoma cells through the release of IGF-I and EGF.

31 March 2020

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Matrix crosslinking forces tumor progression by enhancing integrin signaling

31 March 2020

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Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling

31 March 2020

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Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels

31 March 2020

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Positive and negative influence of the matrix architecture on antitumor immune surveillance

31 March 2020

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Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion

31 March 2020

1 reference

Stem cell pathways contribute to clinical chemoresistance in ovarian cancer

31 March 2020

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Lymph node fibroblastic reticular cells in health and disease

31 March 2020

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Form follows function: lymphoid tissue microarchitecture in antimicrobial immune defence

31 March 2020

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Stromal and hematopoietic cells in secondary lymphoid organs: partners in immunity.

31 March 2020

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Inflammation recapitulates the ontogeny of lymphoid stromal cells.

31 March 2020

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Ectopic lymphoid-like structures in infection, cancer and autoimmunity

31 March 2020

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Characteristics of tertiary lymphoid structures in primary cancers

31 March 2020

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Characterisation and prognostic value of tertiary lymphoid structures in oral squamous cell carcinoma

31 March 2020

1 reference

Presence of B Cells in Tertiary Lymphoid Structures Is Associated with a Protective Immunity in Patients with Lung Cancer

31 March 2020

1 reference

Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity

31 March 2020

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Human solid tumors contain high endothelial venules: association with T- and B-lymphocyte infiltration and favorable prognosis in breast cancer.

31 March 2020

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Neogenesis of lymphoid structures and antibody responses occur in human melanoma metastases.

31 March 2020

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Tumor blood vessels, a difficult hurdle for infiltrating leukocytes

31 March 2020

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12 December 2020

Association of macrophage infiltration with angiogenesis and prognosis in invasive breast carcinoma

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12 December 2020

Endothelial intercellular adhesion molecule-1 expression is suppressed in human malignancies: the role of angiogenic factors

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12 December 2020

Extracellular matrix degradation and remodeling in development and disease

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12 December 2020

Hypoxia-induced, perinecrotic expression of endothelial Per-ARNT-Sim domain protein-1/hypoxia-inducible factor-2alpha correlates with tumor progression, vascularization, and focal macrophage infiltration in bladder cancer

1 reference

12 December 2020

Tumor angiogenesis is accompanied by a decreased inflammatory response of tumor-associated endothelium

1 reference

12 December 2020

Inhibition of the differentiation of dendritic cells from CD34(+) progenitors by tumor cells: role of interleukin-6 and macrophage colony-stimulating factor.

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRI3902

1 reference

4 September 2017

1 reference

PubMed ID

26471778