(Q38619878)

4 September 2017

Mechanosensitivity of integrin adhesion complexes: role of the consensus adhesome (English)

1 reference

4 September 2017

1

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6 June 2020

Pablo Astudillo

series ordinal

2

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6 June 2020

author name string

Martin J Humphries

series ordinal

3

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26515553%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

Jonathan D Humphries

series ordinal

4

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6 June 2020

language of work or name

English

0 references

publication date

26 October 2015

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Experimental Cell Research

4 September 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26515553%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

volume

343

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26515553%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

issue

1

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6 June 2020

page(s)

7-13

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26515553%20AND%20SRC:MED&resulttype=core&format=json

Integrin ligands at a glance

6 June 2020

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The integrin-actin connection, an eternal love affair

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Molecular architecture and function of matrix adhesions

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Integrins: bidirectional, allosteric signaling machines

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Anchors and signals: the diverse roles of integrins in development.

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Role of YAP/TAZ in mechanotransduction

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Matrix elasticity directs stem cell lineage specification

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From tissue mechanics to transcription factors

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Cell-cycle control by physiological matrix elasticity and in vivo tissue stiffening

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The extracellular matrix modulates the hallmarks of cancer

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Mechanoreception at the cell membrane: More than the integrins

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Mechanobiology and developmental control

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Integrins in mechanotransduction

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The integrin adhesome: from genes and proteins to human disease

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Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent manner

7 January 2021

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Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics

7 January 2021

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Stretching single talin rod molecules activates vinculin binding

7 January 2021

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Force Sensing by Mechanical Extension of the Src Family Kinase Substrate p130Cas

7 January 2021

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Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migration

7 January 2021

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Mechanically activated integrin switch controls alpha5beta1 function

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Demonstration of catch bonds between an integrin and its ligand.

7 January 2021

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Cyclic mechanical reinforcement of integrin-ligand interactions

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The switchable integrin adhesome.

7 January 2021

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Functional atlas of the integrin adhesome

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Emerging properties of adhesion complexes: what are they and what do they do?

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Isolation of integrin-based adhesion complexes

7 January 2021

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Isolation of focal adhesion proteins for biochemical and proteomic analysis

7 January 2021

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GEF-H1 controls focal adhesion signaling that regulates mesenchymal stem cell lineage commitment.

7 January 2021

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Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment

7 January 2021

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A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting

7 January 2021

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Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6

7 January 2021

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β1- and αv-class integrins cooperate to regulate myosin II during rigidity sensing of fibronectin-based microenvironments

7 January 2021

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Microtubule-dependent modulation of adhesion complex composition

7 January 2021

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Microtubules regulate focal adhesion dynamics through MAP4K4.

7 January 2021

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Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

7 January 2021

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Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins

7 January 2021

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Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling

7 January 2021

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Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

7 January 2021

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A tense situation: forcing tumour progression

7 January 2021

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Forcing stem cells to behave: a biophysical perspective of the cellular microenvironment.

7 January 2021

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Cell-matrix adhesions in 3D

7 January 2021

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Mechanosensitivity and compositional dynamics of cell-matrix adhesions

7 January 2021

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Forces and bond dynamics in cell adhesion.

7 January 2021

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Opening the floodgates: proteomics and the integrin adhesome

7 January 2021

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Actin and alpha-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner

7 January 2021

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Cell interactions with three-dimensional matrices

7 January 2021

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Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk

7 January 2021

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7 January 2021

Invadosomes at a glance

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Hierarchical assembly of cell-matrix adhesion complexes

7 January 2021

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LIM proteins in actin cytoskeleton mechanoresponse

7 January 2021

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The LIM domain of zyxin is sufficient for force-induced accumulation of zyxin during cell migration

7 January 2021

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The integrin expression profile modulates orientation and dynamics of force transmission at cell-matrix adhesions.

7 January 2021

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Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement

7 January 2021

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Mechanical forces alter zyxin unbinding kinetics within focal adhesions of living cells

7 January 2021

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Mechanosensing in actin stress fibers revealed by a close correlation between force and protein localization

7 January 2021

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Mechanical forces facilitate actin polymerization at focal adhesions in a zyxin-dependent manner.

7 January 2021

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A zyxin-mediated mechanism for actin stress fiber maintenance and repair

7 January 2021

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Stretch-induced actin remodeling requires targeting of zyxin to stress fibers and recruitment of actin regulators

7 January 2021

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Focal adhesion protein zyxin is a mechanosensitive modulator of gene expression in vascular smooth muscle cells

7 January 2021

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Zyxin mediation of stretch-induced gene expression in human endothelial cells.

7 January 2021

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Zyxin is involved in regulation of mechanotransduction in arteriole smooth muscle cells

7 January 2021

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Mechanosensors in integrin signaling: the emerging role of p130Cas

7 January 2021

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Integrin-dependent force transmission to the extracellular matrix by α-actinin triggers adhesion maturation

7 January 2021

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Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylation

7 January 2021

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Paxillin mediates stretch-induced Rho signaling and endothelial permeability via assembly of paxillin-p42/44MAPK-GEF-H1 complex

7 January 2021

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Phosphorylation and turnover of paxillin in focal contacts is controlled by force and defines the dynamic state of the adhesion site

7 January 2021

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LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain

7 January 2021

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Requirement of LIM domains for the transient accumulation of paxillin at damaged stress fibres.

7 January 2021

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The tension mounts: stress fibers as force-generating mechanotransducers

7 January 2021

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Focal adhesion kinase regulation of mechanotransduction and its impact on endothelial cell functions

7 January 2021

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A FAK-Cas-Rac-lamellipodin signaling module transduces extracellular matrix stiffness into mechanosensitive cell cycling.

7 January 2021

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N-Cadherin Induction by ECM Stiffness and FAK Overrides the Spreading Requirement for Proliferation of Vascular Smooth Muscle Cells

7 January 2021

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FAK transduces extracellular forces that orient the mitotic spindle and control tissue morphogenesis.

7 January 2021

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Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling.

7 January 2021

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Loss of keratinocyte focal adhesion kinase stimulates dermal proteolysis through upregulation of MMP9 in wound healing.

7 January 2021

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Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart

7 January 2021

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Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure

7 January 2021

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Integrin-linked kinase mediates force transduction in cardiomyocytes by modulating SERCA2a/PLN function.

7 January 2021

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Pressure-induced vascular oxidative stress is mediated through activation of integrin-linked kinase 1/betaPIX/Rac-1 pathway.

7 January 2021

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ILK mediates the effects of strain on intestinal epithelial wound closure

7 January 2021

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PDMS Elastic Micropost Arrays for Studying Vascular Smooth Muscle Cells.

7 January 2021

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Mechanical stretch inhibits oxidized low density lipoprotein-induced apoptosis in vascular smooth muscle cells by up-regulating integrin alphavbeta3 and stablization of PINCH-1.

7 January 2021

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PINCH proteins regulate cardiac contractility by modulating integrin-linked kinase-protein kinase B signaling.

7 January 2021

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The contractome--a systems view of actomyosin contractility in non-muscle cells.

7 January 2021

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Extracellular-matrix tethering regulates stem-cell fate

7 January 2021

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Concise review: Bone marrow-derived mesenchymal stem cells change phenotype following in vitro culture: implications for basic research and the clinic.

7 January 2021

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Cell adhesion and mechanical stimulation in the regulation of mesenchymal stem cell differentiation

7 January 2021

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The InterPro protein families database: the classification resource after 15 years

7 January 2021

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10.1016/J.YEXCR.2015.10.025

7 January 2021

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26515553%20AND%20SRC:MED&resulttype=core&format=json

6 June 2020

1 reference