(Q38620680)

4 September 2017

Mechanosensing in cell-matrix adhesions - Converting tension into chemical signals (English)

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4 September 2017

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Vesa P Hytönen

1

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author name string

Bernhard Wehrle-Haller

series ordinal

2

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PubMed ID

26518118

4 September 2017

language of work or name

English

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publication date

27 October 2015

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Experimental Cell Research

4 September 2017

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4 September 2017

343

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4 September 2017

1

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4 September 2017

35-41

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Cell movement is guided by the rigidity of the substrate

4 September 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Induction of cell polarization and migration by a gradient of nanoscale variations in adhesive ligand spacing.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Focal contacts as mechanosensors: externally applied local mechanical force induces growth of focal contacts by an mDia1-dependent and ROCK-independent mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Competition between cap and basal actin fiber orientation in cells subjected to contact guidance and cyclic strain.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Activation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Pericellular fibronectin is required for RhoA-dependent responses to cyclic strain in fibroblasts.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Tenascins and the importance of adhesion modulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Prestress in the extracellular matrix sensitizes latent TGF-β1 for activation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Niche anchorage and signaling through membrane-bound Kit-ligand/c-kit receptor are kinase independent and imatinib insensitive.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Tensional homeostasis and the malignant phenotype

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Distinct roles for paxillin and Hic-5 in regulating breast cancer cell morphology, invasion, and metastasis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

The cancer glycocalyx mechanically primes integrin-mediated growth and survival

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Transmembrane crosstalk between the extracellular matrix--cytoskeleton crosstalk

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Force and focal adhesion assembly: a close relationship studied using elastic micropatterned substrates

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Force transduction by Triton cytoskeletons

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Quantitative proteomics of the integrin adhesome show a myosin II-dependent recruitment of LIM domain proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

LIM domains target actin regulators paxillin and zyxin to sites of stress fiber strain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Talin-bound NPLY motif recruits integrin-signaling adapters to regulate cell spreading and mechanosensing

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Matrix elasticity directs stem cell lineage specification

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Role of YAP/TAZ in mechanotransduction

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front-back polarity in migrating cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

FAK promotes recruitment of talin to nascent adhesions to control cell motility

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

RIAM and Vinculin Binding to Talin Are Mutually Exclusive and Regulate Adhesion Assembly and Turnover

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Talins and kindlins: partners in integrin-mediated adhesion.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Structural basis for the autoinhibition of talin in regulating integrin activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

New PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control beta3-integrin clustering

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

The talin-integrin interface under mechanical stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Force-induced activation of talin and its possible role in focal adhesion mechanotransduction.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Stretching single talin rod molecules activates vinculin binding

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Calpain-mediated proteolysis of talin regulates adhesion dynamics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Fibronectin extension and unfolding within cell matrix fibrils controlled by cytoskeletal tension

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Intact alphaIIbbeta3 integrin is extended after activation as measured by solution X-ray scattering and electron microscopy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Recreation of the terminal events in physiological integrin activation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Structure of a Complete Integrin Ectodomain in a Physiologic Resting State and Activation and Deactivation by Applied Forces

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Complete integrin headpiece opening in eight steps

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Demonstration of catch bonds between an integrin and its ligand.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Kindlin-2 (Mig-2): a co-activator of beta3 integrins.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

The Structure of a Full-length Membrane-embedded Integrin Bound to a Physiological Ligand

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

The mechanisms and dynamics of (alpha)v(beta)3 integrin clustering in living cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Identification of LIM3 as the principal determinant of paxillin focal adhesion localization and characterization of a novel motif on paxillin directing vinculin and focal adhesion kinase binding

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Kindlin-2 controls bidirectional signaling of integrins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Kindlin-3 is essential for integrin activation and platelet aggregation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Structural basis for the autoinhibition of focal adhesion kinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Knock-in mutation reveals an essential role for focal adhesion kinase activity in blood vessel morphogenesis and cell motility-polarity but not cell proliferation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Tuning the Mechanical Stability of Fibronectin Type III Modules through Sequence Variations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Mechanical forces regulate the interactions of fibronectin and collagen I in extracellular matrix

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

Stretching fibronectin fibres disrupts binding of bacterial adhesins by physically destroying an epitope

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2015.10.027

10.1016/J.YEXCR.2015.10.027

7 January 2021

Identifiers

DOI

1 reference

4 September 2017

1 reference

PubMed ID

26518118