(Q38621502)

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Structure-Guided Functional Annotation of the Influenza A Virus NS1 Protein Reveals Dynamic Evolution of the p85β-Binding Site During Circulation in Humans

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scholarly article

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Europe PubMed Central

PMC publication ID

28 October 2017

Structure-Guided Functional Annotation of the Influenza A Virus NS1 Protein Reveals Dynamic Evolution of the p85β-Binding Site During Circulation in Humans (English)

1 reference

Europe PubMed Central

PMC publication ID

28 October 2017

protein evolution

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protein structure

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influenza A virus

object named as

Influenza A Virus

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based on heuristic

inferred from title

Patricia Domingues

2

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28814525%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Benjamin G Hale

4

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28814525%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

author name string

Antonio M Lopes

1

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28814525%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Roland Zell

3

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28814525%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

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publication date

16 August 2017

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Europe PubMed Central

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28 October 2017

Journal of Virology

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28814525%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

91

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28814525%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

21

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Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28814525%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

Functional Evolution of Influenza Virus NS1 Protein in Currently Circulating Human 2009 Pandemic H1N1 Viruses.

1 reference

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23 June 2018

Role of Neuraminidase in Influenza A(H7N9) Virus Receptor Binding

1 reference

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23 June 2018

NS1 Protein Amino Acid Changes D189N and V194I Affect Interferon Responses, Thermosensitivity, and Virulence of Circulating H3N2 Human Influenza A Viruses

1 reference

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23 June 2018

NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses.

1 reference

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23 June 2018

Novel Bat Influenza Virus NS1 Proteins Bind Double-Stranded RNA and Antagonize Host Innate Immunity

1 reference

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23 June 2018

A single amino acid substitution in the novel H7N9 influenza A virus NS1 protein increases CPSF30 binding and virulence.

1 reference

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23 June 2018

The NS1 protein: a multitasking virulence factor

1 reference

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23 June 2018

Conformational plasticity of the influenza A virus NS1 protein

1 reference

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23 June 2018

Quantitative proteomic analysis of the influenza A virus nonstructural proteins NS1 and NS2 during natural cell infection identifies PACT as an NS1 target protein and antiviral host factor

1 reference

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23 June 2018

Cellular DDX21 RNA helicase inhibits influenza A virus replication but is counteracted by the viral NS1 protein

1 reference

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23 June 2018

Identification of adaptive mutations in the influenza A virus non-structural 1 gene that increase cytoplasmic localization and differentially regulate host gene expression

1 reference

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23 June 2018

Influenza A/Hong Kong/156/1997(H5N1) virus NS1 gene mutations F103L and M106I both increase IFN antagonism, virulence and cytoplasmic localization but differ in binding to RIG-I and CPSF30

1 reference

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23 June 2018

Synergistic effect of the PDZ and p85β-binding domains of the NS1 protein on virulence of an avian H5N1 influenza A virus

1 reference

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23 June 2018

Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein

1 reference

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23 June 2018

Contribution of NS1 effector domain dimerization to influenza A virus replication and virulence

1 reference

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23 June 2018

Suppression of the antiviral response by an influenza histone mimic

1 reference

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23 June 2018

Influenza virus sequence feature variant type analysis: evidence of a role for NS1 in influenza virus host range restriction.

1 reference

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23 June 2018

Multifunctional adaptive NS1 mutations are selected upon human influenza virus evolution in the mouse.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

23 June 2018

Strain-specific contribution of NS1-activated phosphoinositide 3-kinase signaling to influenza A virus replication and virulence

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

23 June 2018

Influenza research database: an integrated bioinformatics resource for influenza research and surveillance.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

23 June 2018

The avian influenza virus NS1 ESEV PDZ binding motif associates with Dlg1 and Scribble to disrupt cellular tight junctions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

23 June 2018

Dimer interface of the effector domain of non-structural protein 1 from influenza A virus: an interface with multiple functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

23 June 2018

The virulence of 1997 H5N1 influenza viruses in the mouse model is increased by correcting a defect in their NS1 proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

23 June 2018

MEGA5: Molecular Evolutionary Genetics Analysis Using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods

1 reference

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23 June 2018

A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain

1 reference

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23 June 2018

Analysis of the PDZ binding specificities of Influenza A virus NS1 proteins.

1 reference

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23 June 2018

The ESEV PDZ-binding motif of the avian influenza A virus NS1 protein protects infected cells from apoptosis by directly targeting Scribble

1 reference

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23 June 2018

Inefficient control of host gene expression by the 2009 pandemic H1N1 influenza A virus NS1 protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

23 June 2018

Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein

1 reference

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23 June 2018

CRK adaptor protein expression is required for efficient replication of avian influenza A viruses and controls JNK-mediated apoptotic responses

1 reference

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23 June 2018

Identifying changes in selective constraints: host shifts in influenza.

1 reference

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23 June 2018

Loss of function of the influenza A virus NS1 protein promotes apoptosis but this is not due to a failure to activate phosphatidylinositol 3-kinase (PI3K).

1 reference

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23 June 2018

Emergence and pandemic potential of swine-origin H1N1 influenza virus

1 reference

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23 June 2018

Antigenic and genetic characteristics of swine-origin 2009 A(H1N1) influenza viruses circulating in humans

1 reference

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23 June 2018

Functional significance of the hemadsorption activity of influenza virus neuraminidase and its alteration in pandemic viruses.

1 reference

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23 June 2018

Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

23 June 2018

Cation currents in human airway epithelial cells induced by infection with influenza A virus.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

23 June 2018

Structural basis for suppression of a host antiviral response by influenza A virus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

23 June 2018

Structure of an avian influenza A virus NS1 protein effector domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

23 June 2018

Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

23 June 2018

A new influenza virus virulence determinant: the NS1 protein four C-terminal residues modulate pathogenicity

1 reference

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23 June 2018

Identification of human-to-human transmissibility factors in PB2 proteins of influenza A by large-scale mutual information analysis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

23 June 2018

Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling.

1 reference

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Binding of influenza A virus NS1 protein to the inter-SH2 domain of p85 suggests a novel mechanism for phosphoinositide 3-kinase activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

23 June 2018

The influenza virus resource at the National Center for Biotechnology Information

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

23 June 2018

SH3 binding motif 1 in influenza A virus NS1 protein is essential for PI3K/Akt signaling pathway activation

1 reference

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23 June 2018

The H5N1 influenza virus NS genes selected after 1998 enhance virus replication in mammalian cells

1 reference

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23 June 2018

Multiple anti-interferon actions of the influenza A virus NS1 protein

1 reference

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23 June 2018

Influenza A virus NS1 protein activates the PI3K/Akt pathway to mediate antiapoptotic signaling responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

23 June 2018

Influenza A virus NS1 protein activates the phosphatidylinositol 3-kinase (PI3K)/Akt pathway by direct interaction with the p85 subunit of PI3K.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

23 June 2018

Influenza A virus NS1 protein binds p85beta and activates phosphatidylinositol-3-kinase signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

23 June 2018

Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA.

1 reference

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23 June 2018

Large-scale sequence analysis of avian influenza isolates.

1 reference

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23 June 2018

A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice

1 reference

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23 June 2018

Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3' end processing of cellular pre-mRNAS

1 reference

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23 June 2018

Rescue of influenza A virus from recombinant DNA.

1 reference

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23 June 2018

Influenza virus NS1 protein interacts with the cellular 30 kDa subunit of CPSF and inhibits 3'end formation of cellular pre-mRNAs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

23 June 2018

A Single Point Mutation (Y89F) within the Non-Structural Protein 1 of Influenza A Viruses Limits Epithelial Cell Tropism and Virulence in Mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5640874

3 December 2018

Identifiers

10.1128/JVI.01081-17

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28814525%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28814525%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28814525%20AND%20SRC:MED&resulttype=core&format=json

9 June 2020

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