(Q38662646)

5 September 2017

title

Emerging roles of ATRX in cancer (English)

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5 September 2017

L Ashley Watson

1

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5 September 2017

Hannah Goldberg

series ordinal

2

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5 September 2017

Nathalie G Bérubé

series ordinal

3

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5 September 2017

publication date

8 December 2015

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5 September 2017

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5 September 2017

volume

7

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5 September 2017

issue

8

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5 September 2017

page(s)

1365-1378

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Cloning and characterization of a new human Xq13 gene, encoding a putative helicase

5 September 2017

cites work

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ATRX encodes a novel member of the SNF2 family of proteins: mutations point to a common mechanism underlying the ATR-X syndrome

21 January 2018

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Determination of the genomic structure of the XNP/ATRX gene encoding a potential zinc finger helicase

21 January 2018

1 reference

dXNP, a Drosophila homolog of XNP/ATRX, induces apoptosis via Jun-N-terminal kinase activation

21 January 2018

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Characterization of xnp-1, a Caenorhabditis elegans gene similar to the human XNP/ATR-X gene

21 January 2018

1 reference

Cloning and expression of the murine homologue of a putative human X-linked nuclear protein gene closely linked to PGK1 in Xq13.3

21 January 2018

1 reference

Evolution of the SNF2 family of proteins: subfamilies with distinct sequences and functions

21 January 2018

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The SNF/SWI family of global transcriptional activators

21 January 2018

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Structural consequences of disease-causing mutations in the ATRX-DNMT3-DNMT3L (ADD) domain of the chromatin-associated protein ATRX

21 January 2018

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Cloning, expression and chromosome locations of the human DNMT3 gene family

21 January 2018

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Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family

21 January 2018

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Comparison of the human and murine ATRX gene identifies highly conserved, functionally important domains

21 January 2018

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Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain

21 January 2018

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The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies

21 January 2018

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A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein

21 January 2018

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Cell cycle-dependent phosphorylation of the ATRX protein correlates with changes in nuclear matrix and chromatin association

21 January 2018

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Localization of a putative transcriptional regulator (ATRX) at pericentromeric heterochromatin and the short arms of acrocentric chromosomes

21 January 2018

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Interaction between chromatin proteins MECP2 and ATRX is disrupted by mutations that cause inherited mental retardation

21 January 2018

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ATRX marks the inactive X chromosome (Xi) in somatic cells and during imprinted X chromosome inactivation in trophoblast stem cells

21 January 2018

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ATRX directs binding of PRC2 to Xist RNA and Polycomb targets

21 January 2018

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ATRX-mediated chromatin association of histone variant macroH2A1 regulates α-globin expression

21 January 2018

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DNA methylation and chromatin structure

21 January 2018

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Heterochromatin and tri-methylated lysine 20 of histone H4 in animals

21 January 2018

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A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

21 January 2018

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The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain

21 January 2018

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Loss of ATRX leads to chromosome cohesion and congression defects

21 January 2018

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ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

21 January 2018

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Compromised genomic integrity impedes muscle growth after Atrx inactivation.

21 January 2018

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Epigenetic regulation of mammalian pericentric heterochromatin in vivo by HP1.

21 January 2018

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Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin

21 January 2018

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Functional significance of mutations in the Snf2 domain of ATRX.

21 January 2018

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ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome

21 January 2018

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The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9

21 January 2018

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Identification of protein complexes that bind to histone H3 combinatorial modifications using super-SILAC and weighted correlation network analysis

21 January 2018

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ATRX tolerates activity-dependent histone H3 methyl/phos switching to maintain repetitive element silencing in neurons

21 January 2018

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An H3K9/S10 methyl-phospho switch modulates Polycomb and Pol II binding at repressed genes during differentiation

21 January 2018

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Chromatin remodeling and neuronal response: multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons

21 January 2018

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An AT-hook domain in MeCP2 determines the clinical course of Rett syndrome and related disorders

21 January 2018

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ATRX partners with cohesin and MeCP2 and contributes to developmental silencing of imprinted genes in the brain

21 January 2018

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ATR-X syndrome protein targets tandem repeats and influences allele-specific expression in a size-dependent manner.

21 January 2018

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Non-B DNA structure-induced genetic instability and evolution

21 January 2018

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G-quadruplex structures: in vivo evidence and function

21 January 2018

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Quantitative visualization of DNA G-quadruplex structures in human cells

21 January 2018

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ATRX promotes gene expression by facilitating transcriptional elongation through guanine-rich coding regions.

21 January 2018

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Daxx is an H3.3-specific histone chaperone and cooperates with ATRX in replication-independent chromatin assembly at telomeres

21 January 2018

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Distinct factors control histone variant H3.3 localization at specific genomic regions

21 January 2018

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The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3

21 January 2018

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Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3.

21 January 2018

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Transcriptional activation triggers deposition and removal of the histone variant H3.3.

21 January 2018

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Variant histone H3.3 is deposited at sites of nucleosomal displacement throughout transcribed genes while active histone modifications show a promoter-proximal bias

21 January 2018

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Nucleosome stability mediated by histone variants H3.3 and H2A.Z.

21 January 2018

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Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span.

21 January 2018

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A 'higher order' of telomere regulation: telomere heterochromatin and telomeric RNAs

21 January 2018

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Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors.

21 January 2018

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Atrx promotes heterochromatin formation at retrotransposons

21 January 2018

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ATRX Plays a Key Role in Maintaining Silencing at Interstitial Heterochromatic Loci and Imprinted Genes.

21 January 2018

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Histone H3.3 is required for endogenous retroviral element silencing in embryonic stem cells

21 January 2018

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PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1

21 January 2018

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Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRX

21 January 2018

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Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

21 January 2018

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Dynamics of component exchange at PML nuclear bodies.

21 January 2018

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PML bodies provide an important platform for the maintenance of telomeric chromatin integrity in embryonic stem cells

21 January 2018

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Dynamics of histone H3.3 deposition in proliferating and senescent cells reveals a DAXX-dependent targeting to PML-NBs important for pericentromeric heterochromatin organization

21 January 2018

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The HP1-p150/CAF-1 interaction is required for pericentric heterochromatin replication and S-phase progression in mouse cells

21 January 2018

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ATRX dysfunction induces replication defects in primary mouse cells

21 January 2018

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ATRX: taming tandem repeats.

21 January 2018

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The chromatin remodeller ATRX: a repeat offender in human disease

21 January 2018

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Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress

21 January 2018

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Functional human telomeres are recognized as DNA damage in G2 of the cell cycle

21 January 2018

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Spontaneous slow replication fork progression elicits mitosis alterations in homologous recombination-deficient mammalian cells.

21 January 2018

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DNA breaks and chromosome pulverization from errors in mitosis

21 January 2018

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ATRX, a member of the SNF2 family of helicase/ATPases, is required for chromosome alignment and meiotic spindle organization in metaphase II stage mouse oocytes

21 January 2018

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Loss of maternal ATRX results in centromere instability and aneuploidy in the mammalian oocyte and pre-implantation embryo

21 January 2018

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ATRX is required for maintenance of the neuroprogenitor cell pool in the embryonic mouse brain

21 January 2018

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Linking abnormal mitosis to the acquisition of DNA damage

21 January 2018

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Neurodevelopmental defects resulting from ATRX overexpression in transgenic mice.

21 January 2018

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Neuronal death resulting from targeted disruption of the Snf2 protein ATRX is mediated by p53.

21 January 2018

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Histone H3.3 maintains genome integrity during mammalian development

21 January 2018

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Mutations in a putative global transcriptional regulator cause X-linked mental retardation with alpha-thalassemia (ATR-X syndrome)

21 January 2018

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Mutations in the chromatin-associated protein ATRX.

21 January 2018

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Patient mutations alter ATRX targeting to PML nuclear bodies.

21 January 2018

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Gene expression profiles at diagnosis in de novo childhood AML patients identify FLT3 mutations with good clinical outcomes

21 January 2018

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AKT signaling as a novel factor associated with in vitro resistance of human AML to gemtuzumab ozogamicin

21 January 2018

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Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors

21 January 2018

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Loss of DAXX and ATRX are associated with chromosome instability and reduced survival of patients with pancreatic neuroendocrine tumors.

21 January 2018

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Clinicopathologic significance of immunostaining of α-thalassemia/mental retardation syndrome X-linked protein and death domain-associated protein in neuroendocrine tumors

21 January 2018

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Frequent ATRX mutations and loss of expression in adult diffuse astrocytic tumors carrying IDH1/IDH2 and TP53 mutations

21 January 2018

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Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway

21 January 2018

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Decreased expression of the chromatin remodeler ATRX associates with melanoma progression

21 January 2018

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CENP-A nucleosomes localize to transcription factor hotspots and subtelomeric sites in human cancer cells

21 January 2018

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The histone variant macroH2A suppresses melanoma progression through regulation of CDK8.

21 January 2018

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HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres

21 January 2018

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Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP.

21 January 2018

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Mislocalization of the centromeric histone variant CenH3/CENP-A in human cells depends on the chaperone DAXX.

21 January 2018

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DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors

21 January 2018

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Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas

21 January 2018

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Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

21 January 2018

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Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma

21 January 2018

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Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

21 January 2018

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Recurrent somatic structural variations contribute to tumorigenesis in pediatric osteosarcoma.

21 January 2018

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New Epigenetic Drivers of Cancers

21 January 2018

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Surgical management of pancreatic endocrine tumors

21 January 2018

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Altered telomeres in tumors with ATRX and DAXX mutations

21 January 2018

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Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas

21 January 2018

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The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

21 January 2018

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Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma

21 January 2018

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Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein

21 January 2018

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Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation

21 January 2018

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A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling

21 January 2018

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Mutations in CIC and FUBP1 contribute to human oligodendroglioma

21 January 2018

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An integrated genomic analysis of human glioblastoma multiforme

21 January 2018

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

21 January 2018

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IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

21 January 2018

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The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

21 January 2018

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D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function

21 January 2018

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R132H-mutation of isocitrate dehydrogenase-1 is not sufficient for HIF-1α upregulation in adult glioma.

21 January 2018

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Loss of wild-type ATRX expression in somatic cell hybrids segregates with activation of Alternative Lengthening of Telomeres

21 January 2018

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Telomere reduction in human colorectal carcinoma and with ageing

21 January 2018

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Telomerase activity in human ovarian carcinoma

21 January 2018

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TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

21 January 2018

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Alternative lengthening of telomeres: models, mechanisms and implications

21 January 2018

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Release of telomeric DNA from chromosomes in immortal human cells lacking telomerase activity

21 January 2018

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Telomeric recombination in mismatch repair deficient human colon cancer cells after telomerase inhibition

21 January 2018

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Variant repeats are interspersed throughout the telomeres and recruit nuclear receptors in ALT cells.

21 January 2018

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Prevalence of the alternative lengthening of telomeres telomere maintenance mechanism in human cancer subtypes

21 January 2018

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NBS1 and TRF1 colocalize at promyelocytic leukemia bodies during late S/G2 phases in immortalized telomerase-negative cells. Implication of NBS1 in alternative lengthening of telomeres

21 January 2018

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PML nuclear bodies are highly organised DNA-protein structures with a function in heterochromatin remodelling at the G2 phase.

21 January 2018

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Coexistence of alternative lengthening of telomeres and telomerase in hTERT-transfected GM847 cells

21 January 2018

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Mutations in ATRX, encoding a SWI/SNF-like protein, cause diverse changes in the pattern of DNA methylation

21 January 2018

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Loss of ATRX, associated with DNA methylation pattern of chromosome end, impacted biological behaviors of astrocytic tumors

21 January 2018

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Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

21 January 2018

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Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.

21 January 2018

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The SWI/SNF protein ATRX co-regulates pseudoautosomal genes that have translocated to autosomes in the mouse genome

21 January 2018

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Analysis of neonatal brain lacking ATRX or MeCP2 reveals changes in nucleosome density, CTCF binding and chromatin looping

21 January 2018

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HIRA Is Critical for a Nucleosome Assembly Pathway Independent of DNA Synthesis

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/EPI.15.82

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5 September 2017

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