(Q38669030)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28632395%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

title

Design, synthesis and multitarget biological profiling of second-generation anti-Alzheimer rhein-huprine hybrids (English)

1 reference

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23 March 2020

0 references

F Javier Pérez-Areales

1

1 reference

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23 March 2020

Alba Espargaró

5

1 reference

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José Fernando Rinaldi Alvarenga

23 March 2020

8

1 reference

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23 March 2020

author name string

Nibal Betari

2

1 reference

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23 March 2020

Antonio Viayna

3

1 reference

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23 March 2020

Caterina Pont

4

1 reference

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23 March 2020

Manuela Bartolini

6

1 reference

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23 March 2020

Angela De Simone

7

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23 March 2020

Belén Pérez

9

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23 March 2020

Raimon Sabate

10

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23 March 2020

Rosa Maria Lamuela-Raventós

11

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23 March 2020

Vincenza Andrisano

12

1 reference

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23 March 2020

Francisco Javier Luque

13

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23 March 2020

Diego Muñoz-Torrero

14

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23 March 2020

publication date

20 June 2017

1 reference

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Future Medicinal Chemistry

23 March 2020

published in

1 reference

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23 March 2020

volume

9

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23 March 2020

issue

10

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23 March 2020

page(s)

965-981

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Multi-target-directed ligands to combat neurodegenerative diseases

23 March 2020

cites work

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Aurone Mannich base derivatives as promising multifunctional agents with acetylcholinesterase inhibition, anti-β-amyloid aggragation and neuroprotective properties for the treatment of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Synthesis and evaluation of 7-substituted coumarin derivatives as multimodal monoamine oxidase-B and cholinesterase inhibitors for the treatment of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Novel multitarget-directed ligands (MTDLs) with acetylcholinesterase (AChE) inhibitory and serotonergic subtype 4 receptor (5-HT4R) agonist activities as potential agents against Alzheimer's disease: the design of donecopride

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Designing multiple ligands - medicinal chemistry strategies and challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Towards Alzheimer's root cause: ECSIT as an integrating hub between oxidative stress, inflammation and mitochondrial dysfunction. Hypothetical role of the adapter protein ECSIT in familial and sporadic Alzheimer's disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Rhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in AβPPswe/PS-1 Mice of Different Ages.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Unveiling a novel transient druggable pocket in BACE-1 through molecular simulations: Conformational analysis and binding mode of multisite inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

CNS drug design: balancing physicochemical properties for optimal brain exposure

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Core refinement toward permeable β-secretase (BACE-1) inhibitors with low hERG activity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

1,4-Oxazine β-Secretase 1 (BACE1) Inhibitors: From Hit Generation to Orally Bioavailable Brain Penetrant Leads

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

A new and rapid colorimetric determination of acetylcholinesterase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Shogaol-huprine hybrids: dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

2-Arylbenzofuran-based molecules as multipotent Alzheimer's disease modifying agents

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

A comprehensive study on the phenolic profile of widely used culinary herbs and spices: rosemary, thyme, oregano, cinnamon, cumin and bay.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

High throughput artificial membrane permeability assay for blood-brain barrier.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Absolute pK(a) determinations for substituted phenols

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Computational determination of aqueous pKa values of protonated benzimidazoles (part 1).

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Density-functional thermochemistry. III. The role of exact exchange

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Development of the Colle-Salvetti correlation-energy formula into a functional of the electron density

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Calculation of solvation free energies of charged solutes using mixed cluster/continuum models.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

The calculation of small molecular interactions by the differences of separate total energies. Some procedures with reduced errors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Signal transduction and endocytosis: close encounters of many kinds

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Beta-amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for beta-secretase activity in chromaffin vesicles

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Synthesis and structure-activity relationship of Huprine derivatives as human acetylcholinesterase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Novel Tacrine-Benzofuran Hybrids as Potent Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease: Design, Synthesis, Biological Evaluation, and X-ray Crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Huprines for Alzheimer's disease drug development

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Design, synthesis and evaluation of novel tacrine-rhein hybrids as multifunctional agents for the treatment of Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Ultra rapid in vivo screening for anti-Alzheimer anti-amyloid drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Thioflavin-S staining of bacterial inclusion bodies for the fast, simple, and inexpensive screening of amyloid aggregation inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Tetrahydrobenzo[h][1,6]naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies.

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Oxidative stress in Alzheimer's disease: are we connecting the dots?

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Rhein and rhubarb similarly protect the blood-brain barrier after experimental traumatic brain injury via gp91phox subunit of NADPH oxidase/ROS/ERK/MMP-9 signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

Aqueous Solvation Free Energies of Ions and Ion−Water Clusters Based on an Accurate Value for the Absolute Aqueous Solvation Free Energy of the Proton

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

The M06 suite of density functionals for main group thermochemistry, thermochemical kinetics, noncovalent interactions, excited states, and transition elements: two new functionals and systematic testing of four M06-class functionals and 12 other fun

21 January 2018

1 reference

https://api.crossref.org/works/10.4155%2FFMC-2017-0049

21 January 2018

Identifiers

DOI

10.4155/FMC-2017-0049

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28632395%20AND%20SRC:MED&resulttype=core&format=json

23 March 2020

1 reference