(Q39627759)

English

Towards Alzheimer's root cause: ECSIT as an integrating hub between oxidative stress, inflammation and mitochondrial dysfunction. Hypothetical role of the adapter protein ECSIT in familial and sporadic Alzheimer's disease pathogenesis

scientific article published on 19 April 2012

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scholarly article

1 reference

Europe PubMed Central

13 September 2017

Towards Alzheimer's root cause: ECSIT as an integrating hub between oxidative stress, inflammation and mitochondrial dysfunction. Hypothetical role of the adapter protein ECSIT in familial and sporadic Alzheimer's disease pathogenesis (English)

1 reference

Europe PubMed Central

13 September 2017

Alzheimer's disease

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4

1 reference

Europe PubMed Central

13 September 2017

object named as

Nahuai Badiola

2

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Andreas Zanzoni

object named as

Andreas Zanzoni

3

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author name string

Montserrat Soler-López

1

1 reference

Europe PubMed Central

13 September 2017

language of work or name

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publication date

19 April 2012

1 reference

Europe PubMed Central

13 September 2017

1 reference

Europe PubMed Central

13 September 2017

34

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Europe PubMed Central

13 September 2017

7

1 reference

Europe PubMed Central

13 September 2017

532-541

1 reference

Europe PubMed Central

13 September 2017

Alzheimer's Disease

1 reference

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Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

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Intracellular amyloid-beta in Alzheimer's disease

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Compounding artefacts with uncertainty, and an amyloid cascade hypothesis that is 'too big to fail'.

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Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta

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The redox stress hypothesis of aging

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Interactome mapping suggests new mechanistic details underlying Alzheimer's disease

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ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

1 reference

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Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly

1 reference

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21 January 2018

Neuroinflammation in Alzheimer's disease: mechanisms, pathologic consequences, and potential for therapeutic manipulation

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Chronic inflammation in Alzheimer's disease offers therapeutic opportunities.

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Immunology and immunotherapy of Alzheimer's disease

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Microglia and Alzheimer's disease pathogenesis

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Stimulation of chemokine CXC receptor 4 induces synaptic depression of evoked parallel fibers inputs onto Purkinje neurons in mouse cerebellum

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Oxidative damage is the earliest event in Alzheimer disease

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Mitoenergetic failure in Alzheimer disease

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The axonal transport of mitochondria.

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Mitochondrial dysfunction in neurodegenerative diseases

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Differential expression of oxidative phosphorylation genes in patients with Alzheimer's disease: implications for early mitochondrial dysfunction and oxidative damage.

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GM1-ganglioside accumulation at the mitochondria-associated ER membranes links ER stress to Ca(2+)-dependent mitochondrial apoptosis

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Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

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21 January 2018

The Alzheimer's disease mitochondrial cascade hypothesis

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The Alzheimer's disease mitochondrial cascade hypothesis: an update

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Mitochondrial DNA variation in human evolution and disease

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Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.

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Inhibition of amyloid-beta (Abeta) peptide-binding alcohol dehydrogenase-Abeta interaction reduces Abeta accumulation and improves mitochondrial function in a mouse model of Alzheimer's disease

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Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer beta-amyloid peptides

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Common structure and toxic function of amyloid oligomers implies a common mechanism of pathogenesis

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21 January 2018

Mitochondrial γ-secretase participates in the metabolism of mitochondria-associated amyloid precursor protein

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Amyloid-Beta interaction with mitochondria

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Role of mitochondrial amyloid-beta in Alzheimer's disease

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A network medicine approach to human disease

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Systems biology of Alzheimer's disease: how diverse molecular changes result in memory impairment in AD.

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Genomic convergence to identify candidate genes for Alzheimer disease on chromosome 10.

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A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease

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Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants

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Activation and signaling of the p38 MAP kinase pathway

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Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain

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Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis

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Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits

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TLR signalling augments macrophage bactericidal activity through mitochondrial ROS.

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Role of reactive oxygen species and redox in regulating the function of transient receptor potential channels

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Interaction of amyloid binding alcohol dehydrogenase/Abeta mediates up-regulation of peroxiredoxin II in the brains of Alzheimer's disease patients and a transgenic Alzheimer's disease mouse model

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Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

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Apolipoprotein E4 (1-272) fragment is associated with mitochondrial proteins and affects mitochondrial function in neuronal cells

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Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease

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Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

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Apolipoprotein E and cholesterol affect neuronal calcium signalling: the possible relationship to beta-amyloid neurotoxicity

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Effect of the functional toll-like receptor 4 Asp299Gly polymorphism on susceptibility to late-onset Alzheimer's disease.

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Amyloid precursor protein-mediated free radicals and oxidative damage: implications for the development and progression of Alzheimer's disease

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Mitochondrial Ca2+ signalling in hippocampal neurons.

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Neuronal and glial calcium signaling in Alzheimer's disease

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Regulation of NMDA receptor trafficking by amyloid-beta

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Ecsit-ement on the crossroads of Toll and BMP signal transduction

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Microtubule binding to Smads may regulate TGF beta activity

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Toll-like receptor signaling in neural plasticity and disease

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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Identifiers

10.1002/BIES.201100193

1 reference

Europe PubMed Central

13 September 2017

1 reference

Europe PubMed Central

13 September 2017

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