(Q38684019)

18 July 2018

title

DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy (English)

1 reference

18 July 2018

0 references

8

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18 July 2018

author name string

Truc B Nguyen

1

1 reference

18 July 2018

Sharon M Louie

2

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18 July 2018

Joseph R Daniele

3

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18 July 2018

Quan Tran

4

1 reference

18 July 2018

Andrew Dillin

5

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18 July 2018

Roberto Zoncu

6

1 reference

18 July 2018

Daniel K Nomura

7

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18 July 2018

language of work or name

English

0 references

publication date

1 July 2017

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18 July 2018

published in

Developmental Cell

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18 July 2018

volume

42

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18 July 2018

page(s)

9-21.e5

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18 July 2018

issue

1

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18 July 2018

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5553613/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Seipin is required for converting nascent to mature lipid droplets

27 July 2018

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Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells

27 July 2018

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Lipid droplet-mediated ER homeostasis regulates autophagy and cell survival during starvation

27 July 2018

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Lipid droplets and their component triglycerides and steryl esters regulate autophagosome biogenesis

27 July 2018

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27 July 2018

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Diacylglycerol acyl transferase 1 overexpression detoxifies cardiac lipids in PPARγ transgenic mice

27 July 2018

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27 July 2018

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Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation

27 July 2018

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27 July 2018

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ER tubules mark sites of mitochondrial division

27 July 2018

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Tubular network formation protects mitochondria from autophagosomal degradation during nutrient starvation

27 July 2018

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During autophagy mitochondria elongate, are spared from degradation and sustain cell viability.

27 July 2018

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DGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytes

27 July 2018

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

27 July 2018

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27 July 2018

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27 July 2018

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PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation.

27 July 2018

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DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

DGAT1 expression increases heart triglyceride content but ameliorates lipotoxicity

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Sterol and diacylglycerol acyltransferase deficiency triggers fatty acid-mediated cell death

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Autophagy regulates lipid metabolism

27 July 2018

1 reference

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Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis

27 July 2018

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Post-translational regulation of adipose differentiation-related protein by the ubiquitin/proteasome pathway

27 July 2018

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An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

27 July 2018

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Triglyceride accumulation protects against fatty acid-induced lipotoxicity

27 July 2018

1 reference

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A new method for the cytofluorimetric analysis of mitochondrial membrane potential using the J-aggregate forming lipophilic cation 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolcarbocyanine iodide (JC-1).

27 July 2018

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J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential

27 July 2018

1 reference

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Seipin regulates ER-lipid droplet contacts and cargo delivery.

27 July 2018

1 reference

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The Secreted Enzyme PM20D1 Regulates Lipidated Amino Acid Uncouplers of Mitochondria

31 August 2018

1 reference

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Identification and Characterization of Mitochondrial Subtypes in Caenorhabditis elegans via Analysis of Individual Mitochondria by Flow Cytometry

31 August 2018

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Acylcarnitines--old actors auditioning for new roles in metabolic physiology.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

AMPK activation promotes lipid droplet dispersion on detyrosinated microtubules to increase mitochondrial fatty acid oxidation.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Diacylglycerol Metabolism and Signaling Is a Driving Force Underlying FASN Inhibitor Sensitivity in Cancer Cells

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Nutrient-sensing mechanisms across evolution

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Fatty acid trafficking in starved cells: regulation by lipid droplet lipolysis, autophagy, and mitochondrial fusion dynamics

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

The life cycle of lipid droplets

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Nutrient-sensing mechanisms and pathways.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Metabolic control of autophagy

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Sestrins inhibit mTORC1 kinase activation through the GATOR complex

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

ER contact sites define the position and timing of endosome fission

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Improved vectors and genome-wide libraries for CRISPR screening

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Bridging the gap: membrane contact sites in signaling, metabolism, and organelle dynamics

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Simultaneous measurement of individual mitochondrial membrane potential and electrophoretic mobility by capillary electrophoresis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Neutral lipid stores and lipase PNPLA5 contribute to autophagosome biogenesis

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Review: biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

MAM (mitochondria-associated membranes) in mammalian cells: lipids and beyond

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Development of small-molecule inhibitors targeting adipose triglyceride lipase

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Cell survival during complete nutrient deprivation depends on lipid droplet-fueled β-oxidation of fatty acids

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Cancer cells incorporate and remodel exogenous palmitate into structural and oncogenic signaling lipids

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Synchronization of secretory protein traffic in populations of cells.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Lipid transfer and signaling at organelle contact sites: the tip of the iceberg

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Lipolysis - a highly regulated multi-enzyme complex mediates the catabolism of cellular fat stores

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Mammalian autophagy: core molecular machinery and signaling regulation

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Good fat, essential cellular requirements for triacylglycerol synthesis to maintain membrane homeostasis in yeast

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Lipid droplet biogenesis induced by stress involves triacylglycerol synthesis that depends on group VIA phospholipase A2.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Proteolytic and lipolytic responses to starvation

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Degradation of perilipin is mediated through ubiquitination-proteasome pathway

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Regulated translation initiation controls stress-induced gene expression in mammalian cells

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

The relationship between the size of mitochondria and the intensity of light that they scatter in different energetic states

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Storage lipid synthesis is necessary for autophagy induced by nitrogen starvation

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5553613

Flow Cytometric Analysis of Rhodamine 123 Fluorescence during Modulation of the Membrane Potential in Plant Mitochondria

3 December 2018

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12 December 2020

Differential penetration of fatty acyl-coenzyme A and fatty acylcarnitines into phospholipid monolayers

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12 December 2020

Swelling and contraction of the mitochondrial matrix. I. A structural interpretation of the relationship between light scattering and matrix volume

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12 December 2020

The Membrane-Perturbing Properties of Palmitoyl-Coenzyme A and Palmitoylcarnitine. A Comparative Study

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12 December 2020

10.1016/J.DEVCEL.2017.06.003

Identifiers

DOI

1 reference

18 July 2018

PMCID

5553613

1 reference

18 July 2018

PubMed ID

28697336

1 reference

18 July 2018