(Q38705664)

5 September 2017

From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery (English)

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5 September 2017

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1

William A Banks

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5 September 2017

22 January 2016

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Nature Reviews Drug Discovery

5 September 2017

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5 September 2017

15

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5 September 2017

4

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5 September 2017

275-292

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https://scigraph.springernature.com/pub.10.1038/nrd.2015.21

5 September 2017

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cites work

Strategies to advance translational research into brain barriers

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

The blood-brain barrier/neurovascular unit in health and disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Pericytes are required for blood-brain barrier integrity during embryogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Astrocyte-endothelial interactions at the blood-brain barrier

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

The blood-brain barrier in neuroimmunology: Tales of separation and assimilation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Blood-brain barrier and feeding: regulatory roles of saturable transport systems for ingestive peptides

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Interactions of cytokines with the blood-brain barrier: implications for feeding

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Peripheral administration of antisense oligonucleotides targeting the amyloid-β protein precursor reverses AβPP and LRP-1 overexpression in the aged SAMP8 mouse brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Isolation of peptide transport system-6 from brain endothelial cells: therapeutic effects with antisense inhibition in Alzheimer and stroke models

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Proteomic identification of less oxidized brain proteins in aged senescence-accelerated mice following administration of antisense oligonucleotide directed at the Abeta region of amyloid precursor protein

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Central and peripheral administration of antisense oligonucleotide targeting amyloid-β protein precursor improves learning and memory and reduces neuroinflammatory cytokines in Tg2576 (AβPPswe) mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Transport of brain-derived neurotrophic factor across the blood-brain barrier.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Branched-chain amino acids and brain function

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Pegylated leptin antagonist is a potent orexigenic agent: preparation and mechanism of activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Smuggling Drugs into the Brain: An Overview of Ligands Targeting Transcytosis for Drug Delivery across the Blood-Brain Barrier

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Human immunodeficiency virus-1 uses the mannose-6-phosphate receptor to cross the blood-brain barrier

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

A therapeutic antibody targeting BACE1 inhibits amyloid-β production in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Increased brain penetration and potency of a therapeutic antibody using a monovalent molecular shuttle

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Regional variations in the transport of interleukin-1alpha across the blood-brain barrier in ICR and aging SAMP8 mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Selective transport of blood-borne interleukin-1 alpha into the posterior division of the septum of the mouse brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

ABC transporters and the blood-brain barrier

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Efficacy of verapamil as an adjunctive treatment in children with drug-resistant epilepsy: a pilot study.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Regulation of the cerebral circulation: role of endothelium and potassium channels

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Brain endothelial cell production of a neuroprotective cytokine, interleukin-6, in response to noxious stimuli

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Cerebral endothelial cells are a major source of adrenomedullin.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Lipopolysaccharide-enhanced transcellular transport of HIV-1 across the blood-brain barrier is mediated by luminal microvessel IL-6 and GM-CSF.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Brain pericytes increase the lipopolysaccharide-enhanced transcytosis of HIV-1 free virus across the in vitro blood-brain barrier: evidence for cytokine-mediated pericyte-endothelial cell crosstalk

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Permeability studies on in vitro blood-brain barrier models: physiology, pathology, and pharmacology.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Release of cytokines by brain endothelial cells: A polarized response to lipopolysaccharide

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Lipopolysaccharide-induced fever depends on prostaglandin E2 production specifically in brain endothelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Minimal penetration of lipopolysaccharide across the murine blood-brain barrier

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Brain uptake of nonsteroidal anti-inflammatory drugs: ibuprofen, flurbiprofen, and indomethacin.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Evidence for separate mechanisms of induction of biphasic fever inside and outside the blood-brain barrier in rabbits

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Transporters of the blood-brain and blood-CSF interfaces in development and in the adult.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Fasting, but not adrenalectomy, reduces transport of leptin into the brain.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Effects of triglycerides, obesity, and starvation on ghrelin transport across the blood-brain barrier

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Receptor-mediated transport of LIF across blood-spinal cord barrier is upregulated after spinal cord injury.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Stroke upregulates TNFalpha transport across the blood-brain barrier

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Effect of middle cerebral artery occlusion on the passage of pituitary adenylate cyclase activating polypeptide across the blood-brain barrier in the rat.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Neuroinflammation activates Mdr1b efflux transport through NFkappaB: promoter analysis in BBB endothelia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

TNF activates P-glycoprotein in cerebral microvascular endothelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Tumor necrosis factor alpha and endothelin-1 increase P-glycoprotein expression and transport activity at the blood-brain barrier.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Enhanced leptin transport across the blood-brain barrier by alpha 1-adrenergic agents

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Enzyme replacement in murine mucopolysaccharidosis type VII: neuronal and glial response to beta-glucuronidase requires early initiation of enzyme replacement therapy.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Epinephrine enhances lysosomal enzyme delivery across the blood brain barrier by up-regulation of the mannose 6-phosphate receptor

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Role of multidrug transporters in pharmacoresistance to antiepileptic drugs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Body weight, plasma insulin, and coronary events with gemfibrozil in the Veterans Affairs High-Density Lipoprotein Intervention Trial (VA-HIT).

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Is obesity a disease of the blood-brain barrier? Physiological, pathological, and evolutionary considerations

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Neuropathology of the blood-brain barrier and pharmaco-resistance in human epilepsy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Role of P-glycoprotein in refractoriness of seizures to antiepileptic drugs in Lennox-Gastaut syndrome

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Comparison of lipid-mediated blood-brain-barrier penetrability in neonates and adults

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Lipid Solubility and Drug Penetration of the Blood Brain Barrier

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Peptides and the blood-brain barrier: lipophilicity as a predictor of permeability

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Delta-sleep-inducing peptide: solution conformational studies of a membrane-permeable peptide.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Correlation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity with blood-brain barrier monoamine oxidase activity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Axonal degeneration associated with a defective blood-brain barrier in cerebral implants

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

A Possible Enzyme Barrier for γ-Aminobutyric Acid in the Central Nervous System

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Myristic acid conjugation of [D-Leu-4]-OB3, a biologically active leptin-related synthetic peptide amide, significantly improves its pharmacokinetic profile and efficacy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Chemically modified beta-glucuronidase crosses blood-brain barrier and clears neuronal storage in murine mucopolysaccharidosis VII.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Are the extracellular [correction of extracelluar] pathways a conduit for the delivery of therapeutics to the brain?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Serum proteins bypass the blood-brain fluid barriers for extracellular entry to the central nervous system.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Investigation of the influence of FcRn on the distribution of IgG to the brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Anti-amyloid beta protein antibody passage across the blood-brain barrier in the SAMP8 mouse model of Alzheimer's disease: an age-related selective uptake with reversal of learning impairment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Acidification of the endocytic and exocytic pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Endothelial negative surface charge areas and blood-brain barrier function.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Transcytosis of protein through the mammalian cerebral epithelium and endothelium. II. Adsorptive transcytosis of WGA-HRP and the blood-brain and brain-blood barriers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

HIV-1 protein gp120 crosses the blood-brain barrier: role of adsorptive endocytosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

CNS delivery via adsorptive transcytosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Fatty acid acylated Fab-fragments of antibodies to neurospecific proteins as carriers for neuroleptic targeted delivery in brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

A pharmacologically active monoclonal antibody against the human melanocortin-4 receptor: effectiveness after peripheral and central administration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Outwitting the blood-brain barrier for therapeutic purposes: osmotic opening and other means

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Central nervous system penetration for small molecule therapeutic agents does not increase in multiple sclerosis- and Alzheimer's disease-related animal models despite reported blood-brain barrier disruption

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Osmotic-hypertensive opening of the blood-brain barrier in rats does not necessarily provide access for potassium to cerebral interstitial fluid

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Deficiency in mural vascular cells coincides with blood-brain barrier disruption in Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Topiramate treatment protects blood-brain barrier pericytes from hyperglycemia-induced oxidative damage in diabetic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Pericytes and the pathogenesis of diabetic retinopathy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Inflammatory changes and breakdown of microvascular integrity in early human immunodeficiency virus dementia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Monocyte infiltration is highly associated with loss of the tight junction protein zonula occludens in HIV-1-associated dementia

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Ultracytochemical studies of vesicular and canalicular transport structures in the injured mammalian blood-brain barrier

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Mediators of blood-brain barrier dysfunction and formation of vasogenic brain edema

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

eNOS gene deletion restores blood-brain barrier integrity and attenuates neurodegeneration in the thiamine-deficient mouse brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Pharmacological inhibition of mitochondrial carbonic anhydrases protects mouse cerebral pericytes from high glucose-induced oxidative stress and apoptosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Cyclooxygenase inhibition limits blood-brain barrier disruption following intracerebral injection of tumor necrosis factor-alpha in the rat

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Pegylated granulocyte colony-stimulating factor conveys long-term neuroprotection and improves functional outcome in a model of Parkinson's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Glycosylated neuropeptides: a new vista for neuropsychopharmacology?

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Cell-mediated drug delivery.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Effective intravenous therapy for neurodegenerative disease with a therapeutic enzyme and a peptide that mediates delivery to the brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Brain delivery of proteins via their fatty acid and block copolymer modifications

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Defective Glucose Transport across the Blood-Brain Barrier as a Cause of Persistent Hypoglycorrhachia, Seizures, and Developmental Delay

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Blood-brain barrier dysfunction as a cause and consequence of Alzheimer's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Blood-brain barrier in Alzheimer dementia and in non-demented elderly. An immunocytochemical study

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Lipopolysaccharide impairs amyloid β efflux from brain: altered vascular sequestration, cerebrospinal fluid reabsorption, peripheral clearance and transporter function at the blood-brain barrier

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Neurovascular dysfunction, inflammation and endothelial activation: implications for the pathogenesis of Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Neurovascular mechanisms of Alzheimer's neurodegeneration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Restoring blood-brain barrier P-glycoprotein reduces brain amyloid-beta in a mouse model of Alzheimer's disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

RAGE, LRP-1, and amyloid-beta protein in Alzheimer's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

ABC efflux transporters in brain vasculature of Alzheimer's subjects

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Oxidative modification to LDL receptor-related protein 1 in hippocampus from subjects with Alzheimer disease: implications for Aβ accumulation in AD brain

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Blood-brain barrier P-glycoprotein function in Alzheimer's disease.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Testing the neurovascular hypothesis of Alzheimer's disease: LRP-1 antisense reduces blood-brain barrier clearance, increases brain levels of amyloid-beta protein, and impairs cognition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

The critical role of methionine 35 in Alzheimer's amyloid beta-peptide (1-42)-induced oxidative stress and neurotoxicity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Impairments in brain-to-blood transport of amyloid-β and reabsorption of cerebrospinal fluid in an animal model of Alzheimer's disease are reversed by antisense directed against amyloid-β protein precursor.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Pericyte loss influences Alzheimer-like neurodegeneration in mice.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Cerebrospinal fluid and plasma insulin levels in Alzheimer's disease: relationship to severity of dementia and apolipoprotein E genotype.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Starvation and triglycerides reverse the obesity-induced impairment of insulin transport at the blood-brain barrier

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Interactions between the "cognitive" and "metabolic" brain in the control of food intake

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Mononuclear cell trafficking and plasma protein extravasation into the CNS during chronic relapsing experimental allergic encephalomyelitis in Biozzi AB/H mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Cessation of blood-to-brain influx of interleukin-15 during development of EAE

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Blood-brain and blood-spinal cord barrier permeability during the course of experimental allergic encephalomyelitis in the rat.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Loss of astrocytic leptin signaling worsens experimental autoimmune encephalomyelitis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Astrocytes and microglia differentially regulate trafficking of lymphocyte subsets across brain endothelial cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

The effects of natalizumab on the innate and adaptive immune system in the central nervous system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

The blood-brain-barrier in multiple sclerosis: functional roles and therapeutic targeting

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Targeting the CNS to treat type 2 diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Brain insulin controls adipose tissue lipolysis and lipogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Impaired transport of leptin across the blood-brain barrier in obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Activation of nuclear factor-kappaB induced by diabetes and high glucose regulates a proapoptotic program in retinal pericytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Increased blood-brain barrier permeability in type II diabetes demonstrated by gadolinium magnetic resonance imaging

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

High glucose-induced mitochondrial respiration and reactive oxygen species in mouse cerebral pericytes is reversed by pharmacological inhibition of mitochondrial carbonic anhydrases: Implications for cerebral microvascular disease in diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Diabetic retinopathy: mitochondrial dysfunction and retinal capillary cell death

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Targeting carbonic anhydrase to treat diabetic retinopathy: emerging evidences and encouraging results

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Triglycerides induce leptin resistance at the blood-brain barrier

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Glucose and insulin increase the transport of leptin through the blood-brain barrier in normal mice but not in streptozotocin-diabetic mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

1α,25-Dihydroxyvitamin D3 enhances cerebral clearance of human amyloid-β peptide(1-40) from mouse brain across the blood-brain barrier.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Estradiol reduces activity of the blood-brain barrier Na-K-Cl cotransporter and decreases edema formation in permanent middle cerebral artery occlusion

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Phase 1 safety, tolerability and pharmacokinetics of 3K3A-APC in healthy adult volunteers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Release of prostaglandin E-2 in bovine brain endothelial cells after exposure to three unique forms of the antifungal drug amphotericin-B: role of COX-2 in amphotericin-B induced fever

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Evidence that N-acetylcysteine inhibits TNF-alpha-induced cerebrovascular endothelin-1 upregulation via inhibition of mitogen- and stress-activated protein kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

HIV-1-induced production of endothelin-1 in an in vitro model of the human blood-brain barrier.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Endothelin-1 is elevated in the cerebrospinal fluid of HIV-infected patients with encephalopathy

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Targeting the neurovascular unit for treatment of neurological disorders

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Immune activation of human brain microvascular endothelial cells inhibits HIV replication in macrophages

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

STUDIES ON THE RELATIONSHIP OF THE CHEMICAL CONSTITUENTS OF BLOOD AND CEREBROSPINAL FLUID

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Fine structural localization of a blood-brain barrier to exogenous peroxidase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Cutting edge: Natalizumab blocks adhesion but not initial contact of human T cells to the blood-brain barrier in vivo in an animal model of multiple sclerosis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRD.2015.21

Boosting brain uptake of a therapeutic antibody by reducing its affinity for a transcytosis target

31 March 2020

1 reference

12 December 2020

Contribution of extracranial lymphatics and arachnoid villi to the clearance of a CSF tracer in the rat.

1 reference

12 December 2020

Physiological aspects of the penetration of drugs into the cerebrospinal fluid

1 reference

12 December 2020

Immunocytochemical studies of protamine-induced blood-brain barrier opening to endogenous albumin.

1 reference

12 December 2020

Lipid solubility and drug penetration of the blood brain barrier

1 reference

12 December 2020

Treatment of experimental autoimmune encephalomyelitis with antisense oligonucleotides against the low affinity neurotrophin receptor

1 reference

12 December 2020

Relationship between cyclophilin a levels and matrix metalloproteinase 9 activity in cerebrospinal fluid of cognitively normal apolipoprotein e4 carriers and blood-brain barrier breakdown

1 reference

12 December 2020

Role of P-glycoprotein in the blood-brain transport of colchicine and vinblastine

1 reference

12 December 2020

Soluble interleukin-6 receptor induces motor stereotypies and co-localizes with gp130 in regions linked to cortico-striato-thalamo-cortical circuits

1 reference

12 December 2020

Effect of peptidases at the blood brain barrier on the permeability of enkephalin

1 reference

12 December 2020

Streptozotocin-induced diabetes progressively increases blood-brain barrier permeability in specific brain regions in rats

1 reference

12 December 2020

Nitric oxide production and MDR expression by human brain endothelial cells.

1 reference

12 December 2020

Distribution of drugs between blood and cerebrospinal fluid: general methodology and effect of pH gradients.

1 reference

12 December 2020

Recent progress in tight junction modulation for improving bioavailability

1 reference

12 December 2020

Pathogen-inspired drug delivery to the central nervous system

1 reference

12 December 2020

The effect of rosiglitazone on LRP1 expression and amyloid β uptake in human brain microvascular endothelial cells: a possible role of a low-dose thiazolidinedione for dementia treatment

1 reference

12 December 2020

Net amino acid transport between plasma and erythrocytes and perfused dog brain.

1 reference

12 December 2020

Blood-brain barrier drug delivery of IgG fusion proteins with a transferrin receptor monoclonal antibody

1 reference

12 December 2020

Involvement of cyclooxygenase-2 in LPS-induced fever and regulation of its mRNA by LPS in the rat brain

1 reference

12 December 2020

Delivery across the blood-brain barrier of antisense directed against amyloid beta: reversal of learning and memory deficits in mice overexpressing amyloid precursor protein.

1 reference

12 December 2020

Red blood cell as glucose carrier: significance for placental and cerebral glucose transfer

1 reference

12 December 2020

The effect of verapamil on the transport of peptides across the blood-brain barrier in rats: kinetic evidence for an apically polarized efflux mechanism

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRD.2015.21

1 reference

5 September 2017

1 reference

PubMed ID

26794270