(Q38727477)

5 September 2017

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title

Dynamic stem cell states: naive to primed pluripotency in rodents and humans (English)

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5 September 2017

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4

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5 September 2017

Noa Novershtern

3

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author name string

Leehee Weinberger

series ordinal

1

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PubMed ID

26860365

5 September 2017

Muneef Ayyash

series ordinal

2

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5 September 2017

10 February 2016

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Nature Reviews Molecular Cell Biology

5 September 2017

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5 September 2017

17

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5 September 2017

3

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5 September 2017

155-169

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https://scigraph.springernature.com/pub.10.1038/nrm.2015.28

5 September 2017

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Pluripotent cell derivation from male germline cells by suppression of Dmrt1 and Trp53.

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Derivation of pluripotent stem cells from cultured human primordial germ cells

31 March 2020

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Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells

31 March 2020

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Human embryonic stem cells derived by somatic cell nuclear transfer.

31 March 2020

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Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer.

31 March 2020

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

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Induction of pluripotent stem cells from adult human fibroblasts by defined factors

31 March 2020

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In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

31 March 2020

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Human induced pluripotent stem cells free of vector and transgene sequences

31 March 2020

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Induced pluripotent stem cell lines derived from human somatic cells

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SCNT-derived ESCs with mismatched mitochondria trigger an immune response in allogeneic hosts

31 March 2020

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Metabolic rescue in pluripotent cells from patients with mtDNA disease

31 March 2020

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Mitochondrial gene replacement in primate offspring and embryonic stem cells

31 March 2020

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Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2015.28

Metastable pluripotent states in NOD-mouse-derived ESCs

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2015.28

Naive and primed pluripotent states

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2015.28

Direct reprogramming of fibroblasts into epiblast stem cells.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2015.28

Isolation of epiblast stem cells from preimplantation mouse embryos.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2015.28

Differentiation of clonal lines of teratocarcinoma cells: formation of embryoid bodies in vitro

31 March 2020

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Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

31 March 2020

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Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

31 March 2020

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Chromatin connections to pluripotency and cellular reprogramming

31 March 2020

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BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3

31 March 2020

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Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells.

31 March 2020

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The ground state of embryonic stem cell self-renewal

31 March 2020

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Capture of authentic embryonic stem cells from rat blastocysts

31 March 2020

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Validated germline-competent embryonic stem cell lines from nonobese diabetic mice

31 March 2020

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Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells

31 March 2020

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Dual inhibition of Src and GSK3 maintains mouse embryonic stem cells, whose differentiation is mechanically regulated by Src signaling.

31 March 2020

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Self-renewal versus lineage commitment of embryonic stem cells: protein kinase C signaling shifts the balance

31 March 2020

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Single Cell RNA-Sequencing of Pluripotent States Unlocks Modular Transcriptional Variation

31 March 2020

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Robust self-renewal of rat embryonic stem cells requires fine-tuning of glycogen synthase kinase-3 inhibition

31 March 2020

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Tuning of β-catenin activity is required to stabilize self-renewal of rat embryonic stem cells.

31 March 2020

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Inhibition of protein kinase C signaling maintains rat embryonic stem cell pluripotency

31 March 2020

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Calcineurin-NFAT signaling critically regulates early lineage specification in mouse embryonic stem cells and embryos

31 March 2020

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The Hippo signaling pathway components Lats and Yap pattern Tead4 activity to distinguish mouse trophectoderm from inner cell mass

31 March 2020

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YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response

31 March 2020

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The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation

31 March 2020

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Inhibition of glycogen synthase kinase-3 alleviates Tcf3 repression of the pluripotency network and increases embryonic stem cell resistance to differentiation.

31 March 2020

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A membrane-associated β-catenin/Oct4 complex correlates with ground-state pluripotency in mouse embryonic stem cells

31 March 2020

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LIF supports primitive endoderm expansion during pre-implantation development

31 March 2020

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Nanog is the gateway to the pluripotent ground state.

31 March 2020

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Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors

31 March 2020

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Nanog-independent reprogramming to iPSCs with canonical factors

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRM.2015.28

Nanog is dispensable for the generation of induced pluripotent stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Klf2 is an essential factor that sustains ground state pluripotency.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Deterministic direct reprogramming of somatic cells to pluripotency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

A precarious balance: pluripotency factors as lineage specifiers.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

In Vivo differentiation potential of epiblast stem cells revealed by chimeric embryo formation.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Reorganization of enhancer patterns in transition from naive to primed pluripotency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

The transcriptional and epigenomic foundations of ground state pluripotency.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Derivation of novel human ground state naive pluripotent stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Epigenomic comparison reveals activation of "seed" enhancers during transition from naive to primed pluripotency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Deconstructing transcriptional heterogeneity in pluripotent stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Modulation of β-catenin function maintains mouse epiblast stem cell and human embryonic stem cell self-renewal

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

An alternative pluripotent state confers interspecies chimaeric competency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Epiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Reconstitution of the mouse germ cell specification pathway in culture by pluripotent stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Klf4 reverts developmentally programmed restriction of ground state pluripotency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Epiblast stem cell-based system reveals reprogramming synergy of germline factors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Conserved and divergent roles of FGF signaling in mouse epiblast stem cells and human embryonic stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Naive pluripotency is associated with global DNA hypomethylation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Synergistic mechanisms of DNA demethylation during transition to ground-state pluripotency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Ground State Conditions Induce Rapid Reorganization of Core Pluripotency Factor Binding before Global Epigenetic Reprogramming

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Erk1/2 activity promotes chromatin features and RNAPII phosphorylation at developmental promoters in mouse ESCs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Activin/nodal signaling and NANOG orchestrate human embryonic stem cell fate decisions by controlling the H3K4me3 chromatin mark.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

DNA methylation dynamics of the human preimplantation embryo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Erosion of dosage compensation impacts human iPSC disease modeling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

A genome-wide RNAi screen reveals determinants of human embryonic stem cell identity.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Systematic identification of culture conditions for induction and maintenance of naive human pluripotency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Resetting transcription factor control circuitry toward ground-state pluripotency in human

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Defining the three cell lineages of the human blastocyst by single-cell RNA-seq.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

DNA Demethylation Dynamics in the Human Prenatal Germline

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

CD24 tracks divergent pluripotent states in mouse and human cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Stable X chromosome reactivation in female human induced pluripotent stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Induction of a human pluripotent state with distinct regulatory circuitry that resembles preimplantation epiblast.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Alternative Routes to Induce Naïve Pluripotency in Human Embryonic Stem Cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Reinforcement of STAT3 activity reprogrammes human embryonic stem cells to naive-like pluripotency.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Human ERas gene has an upstream premature polyadenylation signal that results in a truncated, noncoding transcript.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Lineage-Specific Profiling Delineates the Emergence and Progression of Naive Pluripotency in Mammalian Embryogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Enhancers as information integration hubs in development: lessons from genomics.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Reduced Oct4 expression directs a robust pluripotent state with distinct signaling activity and increased enhancer occupancy by Oct4 and Nanog

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Marked differences in differentiation propensity among human embryonic stem cell lines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

SOX17 is a critical specifier of human primordial germ cell fate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell lines

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Generation of Cynomolgus Monkey Chimeric Fetuses using Embryonic Stem Cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Generation of naive induced pluripotent stem cells from rhesus monkey fibroblasts.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Effect of Gsk3 inhibitor CHIR99021 on aneuploidy levels in rat embryonic stem cells.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Systematic identification of barriers to human iPSC generation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Donor cell type can influence the epigenome and differentiation potential of human induced pluripotent stem cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Abnormalities in human pluripotent cells due to reprogramming mechanisms

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

Naive Human Pluripotent Cells Feature a Methylation Landscape Devoid of Blastocyst or Germline Memory

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM.2015.28

31 March 2020

Identifiers

DOI

10.1038/NRM.2015.28

1 reference

PubMed ID

26860365

Dimensions Publication ID

5 September 2017

0 references

1 reference

PubMed ID

26860365