(Q38746611)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

title

Suppressive effects of tumor cell-derived 5'-deoxy-5'-methylthioadenosine on human T cells (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

5

1 reference

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22 March 2020

Simon Völkl

9

1 reference

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22 March 2020

Anja Bosserhoff

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

author name string

Frederik C Henrich

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Katrin Singer

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Kerstin Poller

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Luise Bernhardt

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Katharina Limm

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Axel P Ritter

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Eva Gottfried

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Benedikt Jacobs

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Katrin Peter

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Dimitrios Mougiakakos

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Katja Dettmer

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Peter J Oefner

14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Marina P Kreutz

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Michael Aigner

17

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

Andreas Mackensen

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

publication date

10 June 2016

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

issue

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

page(s)

e1184802

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

describes a project that uses

22 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5007975/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

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MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

6 September 2017

1 reference

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Critical role of transmethylation in TLR signaling and systemic lupus erythematosus

6 September 2017

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Protein arginine methyltransferases and cancer

6 September 2017

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Lupus autoimmunity altered by cellular methylation metabolism

6 September 2017

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Cellular constituents of immune escape within the tumor microenvironment

6 September 2017

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Tumor metabolism as modulator of immune response and tumor progression

6 September 2017

1 reference

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Transmethylation in immunity and autoimmunity

6 September 2017

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Camouflage and sabotage: tumor escape from the immune system

6 September 2017

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Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapy

6 September 2017

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Hallmarks of Cancer: The Next Generation

6 September 2017

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Down-regulation of methylthioadenosine phosphorylase (MTAP) induces progression of hepatocellular carcinoma via accumulation of 5'-deoxy-5'-methylthioadenosine (MTA).

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Targeting tumors that lack methylthioadenosine phosphorylase (MTAP) activity: current strategies

6 September 2017

1 reference

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Suppression of T-cell responses by tumor metabolites

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Methylthioadenosine (MTA) inhibits melanoma cell proliferation and in vivo tumor growth

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Protein arginine methylation: a new handle on T lymphocytes?

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Anergic T cells are metabolically anergic

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Mice heterozygous for germ-line mutations in methylthioadenosine phosphorylase (MTAP) die prematurely of T-cell lymphoma

6 September 2017

1 reference

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DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

6 September 2017

1 reference

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

6 September 2017

1 reference

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Suppressive influences in the immune response to cancer

6 September 2017

1 reference

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Use of tumour-responsive T cells as cancer treatment

6 September 2017

1 reference

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The tumor microenvironment and its role in promoting tumor growth

6 September 2017

1 reference

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Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1

6 September 2017

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Tumor cell metabolism: cancer's Achilles' heel

6 September 2017

1 reference

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Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (Review).

6 September 2017

1 reference

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The biology of cancer: metabolic reprogramming fuels cell growth and proliferation

6 September 2017

1 reference

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Inhibition of methyltransferases results in induction of g2/m checkpoint and programmed cell death in human T-lymphotropic virus type 1-transformed cells

6 September 2017

1 reference

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A potential predictive marker for response to interferon in malignant melanoma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

A2A adenosine receptor protects tumors from antitumor T cells.

6 September 2017

1 reference

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Protein arginine methylation in lymphocyte signaling

6 September 2017

1 reference

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EFA (9-beta-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine

6 September 2017

1 reference

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Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma

6 September 2017

1 reference

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CD28 costimulatory signal induces protein arginine methylation in T cells.

6 September 2017

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New insights into adenosine-receptor-mediated immunosuppression and the role of adenosine in causing the immunodeficiency associated with adenosine deaminase deficiency

6 September 2017

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Strong expression of methylthioadenosine phosphorylase (MTAP) in human colon carcinoma cells is regulated by TCF1/[beta]-catenin

6 September 2017

1 reference

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6 September 2017

1 reference

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Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Methylthioadenosine phosphorylase, a gene frequently codeleted with p16(cdkN2a/ARF), acts as a tumor suppressor in a breast cancer cell line

6 September 2017

1 reference

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Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes

6 September 2017

1 reference

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Assignment of the gene for methylthioadenosine phosphorylase to human chromosome 9 by mouse-human somatic cell hybridization

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Deregulation of protein methylation in melanoma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Characterization of MHC class-I restricted TCRalphabeta+ CD4- CD8- double negative T cells recognizing the gp100 antigen from a melanoma patient after gp100 vaccination

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Comprehensive identification of arginine methylation in primary T cells reveals regulatory roles in cell signalling

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Quantification of intermediates of the methionine and polyamine metabolism by liquid chromatography-tandem mass spectrometry in cultured tumor cells and liver biopsies

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

The role of 5′-methylthioadenosine phosphorylase in 5′-methylthioadenosine-mediated inhibition of lymphocyte transformation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Quantitative analysis of 5'-deoxy-5'-methylthioadenosine in melanoma cells by liquid chromatography-stable isotope ratio tandem mass spectrometry

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Phase I study of adoptive T-cell therapy using antigen-specific CD8+ T cells for the treatment of patients with metastatic melanoma.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

5'-methylthioadenosine modulates the inflammatory response to endotoxin in mice and in rat hepatocytes.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Survival and tumor localization of adoptively transferred Melan-A-specific T cells in melanoma patients

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Trends in the biochemical pharmacology of 5'-deoxy-5'-methylthioadenosine

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Tumor-specific cytotoxic T cell clones from patients with breast and pancreatic adenocarcinoma recognize EBV-immortalized B cells transfected with polymorphic epithelial mucin complementary DNA.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Tumor-specific lysis of human renal cell carcinomas by tumor-infiltrating lymphocytes. I. HLA-A2-restricted recognition of autologous and allogeneic tumor lines.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

5'-deoxy-5'-methylthioadenosine phosphorylase--II. Role of the enzyme in the metabolism and antineoplastic action of adenine-substituted analogs of 5'-deoxy-5'-methylthioadenosine

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

The Specificity of S-Adenosylmethionine Derivatives in Methyl Transfer Reactions

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Inhibition of macrophage phagocytosis by methylation inhibitors. Lack of correlation of protein carboxymethylation and phospholipid methylation with phagocytosis

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

The emerging "hallmarks" of metabolic reprogramming and immune evasion: distinct or linked?

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

High DGK-α and disabled MAPK pathways cause dysfunction of human tumor-infiltrating CD8+ T cells that is reversible by pharmacologic intervention.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Warburg phenotype in renal cell carcinoma: high expression of glucose-transporter 1 (GLUT-1) correlates with low CD8(+) T-cell infiltration in the tumor

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Methylthioadenosine phosphorylase represents a predictive marker for response to adjuvant interferon therapy in patients with malignant melanoma

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

The T-cell-receptor signaling network

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Direct and tumor microenvironment mediated influences of 5'-deoxy-5'-(methylthio)adenosine on tumor progression of malignant melanoma

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Methylthioadenosine reverses brain autoimmune disease

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Arginine methylation of NIP45 modulates cytokine gene expression in effector T lymphocytes

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

S-adenosylmethionine and methylthioadenosine are antiapoptotic in cultured rat hepatocytes but proapoptotic in human hepatoma cells.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

5'-Methylthioadenosine administration prevents lipid peroxidation and fibrogenesis induced in rat liver by carbon-tetrachloride intoxication.

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

The methylthioadenosine phosphorylase gene is frequently co-deleted with the p16INK4a gene in acute type adult T-cell leukemia

31 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5007975

Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways

31 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1080%2F2162402X.2016.1184802

Inhibition of lymphocyte transformation by a naturally occurring metabolite: 5'-methylthioadenosine

21 January 2018

1 reference

12 December 2020

Modulation of adenine nucleoside excretion and incorporation in adenosine deaminase deficient human lymphoma cells

1 reference

12 December 2020

Inhibition of lymphocyte function by a naturally occurring nucleoside: 5'-methylthioadenosine (MTA)

1 reference

12 December 2020

5′-Deoxy-5′-methylthioadenosine inhibition of rat T lymphocyte phosphodiesterase : Correlation with inhibition of Con A induced proliferation

1 reference

12 December 2020

CD8(+) tumor-infiltrating T cells are deficient in perforin-mediated cytolytic activity due to defective microtubule-organizing center mobilization and lytic granule exocytosis

1 reference

12 December 2020

Effect of 5'-methylthioadenosine, 3-deazaadenosine, and related compounds on human natural killer cell activity. Relation to cyclic AMP and methylation potential

1 reference

12 December 2020

Structural analogs of 5'-methylthioadenosine as substrates and inhibitors of 5'-methylthioadenosine phosphorylase and as inhibitors of human lymphocyte transformation

1 reference

12 December 2020

Inhibitory effect of tumor cell-derived lactic acid on human T cells

1 reference

12 December 2020

Effect of 5''-methylthioadenosine and its analogs on murine lymphoid cell proliferation

1 reference

12 December 2020

Abnormal regulation of methylthioadenosine and polyamine metabolism in methylthioadenosine phosphorylase-deficient human leukemic cell lines

1 reference

12 December 2020

Methylthio group cleavage from methylthioadenosine. Description of an enzyme and its relationship to the methylthio requirement of certain cells in culture

1 reference

12 December 2020

10.1080/2162402X.2016.1184802

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27622058%20AND%20SRC:MED&resulttype=core&format=json

22 March 2020

PubMed publication ID

27622058

1 reference