(Q38752928)

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SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents.

scientific article published on 8 August 2016

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20 March 2020

SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents (English)

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20 March 2020

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Warren Fiskus

1

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20 March 2020

Veena Coothankandaswamy

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20 March 2020

Jianguang Chen

3

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20 March 2020

Hongwei Ma

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20 March 2020

Kyungsoo Ha

5

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20 March 2020

Stephanie S Krieger

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20 March 2020

Christopher P Mill

8

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20 March 2020

Baohua Sun

9

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20 March 2020

Peng Huang

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20 March 2020

Ari M Melnick

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20 March 2020

Kapil N Bhalla

13

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20 March 2020

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8 August 2016

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20 March 2020

Cancer Research

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20 March 2020

76

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20 March 2020

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20 March 2020

5467-5478

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20 March 2020

The multifaceted functions of sirtuins in cancer

1 reference

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23 June 2018

2D-DIGE proteomic analysis identifies new potential therapeutic targets for adrenocortical carcinoma.

1 reference

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23 June 2018

Histone deacetylase inhibitor treatment induces 'BRCAness' and synergistic lethality with PARP inhibitor and cisplatin against human triple negative breast cancer cells

1 reference

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23 June 2018

SIRT2 interacts with β-catenin to inhibit Wnt signaling output in response to radiation-induced stress

1 reference

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23 June 2018

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

1 reference

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23 June 2018

Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase

1 reference

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23 June 2018

Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress

1 reference

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Auranofin induces lethal oxidative and endoplasmic reticulum stress and exerts potent preclinical activity against chronic lymphocytic leukemia

1 reference

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23 June 2018

Highly active combination of BRD4 antagonist and histone deacetylase inhibitor against human acute myelogenous leukemia cells.

1 reference

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23 June 2018

An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms

1 reference

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23 June 2018

Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth

1 reference

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Forkhead box proteins: tuning forks for transcriptional harmony.

1 reference

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23 June 2018

The NAD-dependent deacetylase SIRT2 is required for programmed necrosis

1 reference

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23 June 2018

From sirtuin biology to human diseases: an update

1 reference

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23 June 2018

Peroxiredoxins, gerontogenes linking aging to genome instability and cancer.

1 reference

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23 June 2018

Automated reporter quantification in vivo: high-throughput screening method for reporter-based assays in zebrafish

1 reference

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23 June 2018

SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345574

23 June 2018

Hsp90 inhibitor-mediated disruption of chaperone association of ATR with hsp90 sensitizes cancer cells to DNA damage

1 reference

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23 June 2018

Do reactive oxygen species play a role in myeloid leukemias?

1 reference

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23 June 2018

Inactivation of peroxiredoxin I by phosphorylation allows localized H(2)O(2) accumulation for cell signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345574

23 June 2018

Structural basis for sirtuin function: what we know and what we don't

1 reference

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23 June 2018

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

1 reference

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23 June 2018

Prdx1 inhibits tumorigenesis via regulating PTEN/AKT activity

1 reference

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23 June 2018

Redox-regulated chaperones

1 reference

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23 June 2018

HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation

1 reference

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23 June 2018

Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion

1 reference

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23 June 2018

Thiol chemistry in peroxidase catalysis and redox signaling

1 reference

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23 June 2018

Up-regulation of peroxiredoxin 1 in lung cancer and its implication as a prognostic and therapeutic target.

1 reference

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23 June 2018

Are peroxiredoxins tumor suppressors?

1 reference

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23 June 2018

SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345574

23 June 2018

Human peroxiredoxin 1 and 2 are not duplicate proteins: the unique presence of CYS83 in Prx1 underscores the structural and functional differences between Prx1 and Prx2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5345574

23 June 2018

Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia/reoxygenation: implication to tumor biology

1 reference

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23 June 2018

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

1 reference

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23 June 2018

Inhibition of lung tumor growth and augmentation of radiosensitivity by decreasing peroxiredoxin I expression

1 reference

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23 June 2018

2-Cys peroxiredoxin function in intracellular signal transduction: therapeutic implications

1 reference

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23 June 2018

Regulation of reactive oxygen species, DNA damage, and c-Myc function by peroxiredoxin 1

1 reference

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23 June 2018

Oxidative stress-dependent structural and functional switching of a human 2-Cys peroxiredoxin isotype II that enhances HeLa cell resistance to H2O2-induced cell death.

1 reference

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23 June 2018

Peroxiredoxins, oxidative stress, and cell proliferation.

1 reference

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23 June 2018

Two enzymes in one; two yeast peroxiredoxins display oxidative stress-dependent switching from a peroxidase to a molecular chaperone function

1 reference

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Proteomic analysis of lung biopsies: Differential protein expression profile between peritumoral and tumoral tissue

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Proteomics-based identification of differentially expressed genes in human gliomas: down-regulation of SIRT2 gene

1 reference

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Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression

1 reference

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23 June 2018

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

1 reference

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23 June 2018

Structure, mechanism and regulation of peroxiredoxins

1 reference

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23 June 2018

Proteomics analysis of cellular response to oxidative stress. Evidence for in vivo overoxidation of peroxiredoxins at their active site

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Arsenic impairs embryo development via down-regulating Dvr1 expression in zebrafish

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Enhanced expression of peroxiredoxin I and VI correlates with development, recurrence and progression of human bladder cancer.

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31 August 2018

Activity assay of mammalian 2-cys peroxiredoxins using yeast thioredoxin reductase system

1 reference

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31 August 2018

Identifiers

10.1158/0008-5472.CAN-16-0126

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20 March 2020

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20 March 2020

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20 March 2020

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