(Q34494682)

2 August 2017

title

The multifaceted functions of sirtuins in cancer (English)

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2 August 2017

Angeliki Chalkiadaki

1

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2 August 2017

Leonard Guarente

series ordinal

2

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2 August 2017

language of work or name

English

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publication date

18 September 2015

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2 August 2017

published in

Nature Reviews Cancer

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2 August 2017

volume

15

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2 August 2017

issue

10

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2 August 2017

page(s)

608-624

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https://scigraph.springernature.com/pub.10.1038/nrc3985

2 August 2017

exact match

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cites work

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Calorie restriction and sirtuins revisited

31 March 2020

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Franklin H. Epstein Lecture: Sirtuins, aging, and medicine

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Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

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Metabolic reprogramming: a cancer hallmark even warburg did not anticipate

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Hallmarks of Cancer: The Next Generation

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Sirtuins mediate mammalian metabolic responses to nutrient availability

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SIRT1 and other sirtuins in metabolism

31 March 2020

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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

31 March 2020

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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

31 March 2020

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Resveratrol improves health and survival of mice on a high-calorie diet

31 March 2020

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Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation

31 March 2020

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SIRT1 transgenic mice show phenotypes resembling calorie restriction

31 March 2020

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Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

31 March 2020

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Sirt1 protects against high-fat diet-induced metabolic damage

31 March 2020

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Negative control of p53 by Sir2alpha promotes cell survival under stress

31 March 2020

1 reference

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

31 March 2020

1 reference

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

31 March 2020

1 reference

Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage

31 March 2020

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The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

31 March 2020

1 reference

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging

31 March 2020

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Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice

31 March 2020

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Role of SIRT1 in regulation of epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis

31 March 2020

1 reference

Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis

31 March 2020

1 reference

SIRT1 suppresses the epithelial-to-mesenchymal transition in cancer metastasis and organ fibrosis

31 March 2020

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A BCL6/BCOR/SIRT1 complex triggers neurogenesis and suppresses medulloblastoma by repressing Sonic Hedgehog signaling

31 March 2020

1 reference

Preclinical evaluation of a novel SIRT1 modulator SRT1720 in multiple myeloma cells

31 March 2020

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SRT1720 induces lysosomal-dependent cell death of breast cancer cells

31 March 2020

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DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia.

31 March 2020

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SIRT1 and c-Myc promote liver tumor cell survival and predict poor survival of human hepatocellular carcinomas

31 March 2020

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High levels of SIRT1 expression enhance tumorigenesis and associate with a poor prognosis of colorectal carcinoma patients

31 March 2020

1 reference

The c-MYC oncoprotein, the NAMPT enzyme, the SIRT1-inhibitor DBC1, and the SIRT1 deacetylase form a positive feedback loop

31 March 2020

1 reference

SIRT1 activation by a c-MYC oncogenic network promotes the maintenance and drug resistance of human FLT3-ITD acute myeloid leukemia stem cells

31 March 2020

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Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with imatinib

31 March 2020

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SIRT1 promotes thyroid carcinogenesis driven by PTEN deficiency.

31 March 2020

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SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol

31 March 2020

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Enterocyte-specific inactivation of SIRT1 reduces tumor load in the APC(+/min) mouse model

31 March 2020

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Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

31 March 2020

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p53 activates expression of HIC-1, a new candidate tumour suppressor gene on 17p13.3

31 March 2020

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DBC2, a candidate for a tumor suppressor gene involved in breast cancer

31 March 2020

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DBC1 is a negative regulator of SIRT1

31 March 2020

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Negative regulation of the deacetylase SIRT1 by DBC1

31 March 2020

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Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.

31 March 2020

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Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

31 March 2020

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MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells

31 March 2020

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miR-34a repression of SIRT1 regulates apoptosis

31 March 2020

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Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis

31 March 2020

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SIRT1 deacetylase promotes acquisition of genetic mutations for drug resistance in CML cells

31 March 2020

1 reference

Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1.

31 March 2020

1 reference

Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells

31 March 2020

1 reference

Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes

31 March 2020

1 reference

SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity

31 March 2020

1 reference

SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

31 March 2020

1 reference

Significance of Aurora B overexpression in hepatocellular carcinoma. Aurora B Overexpression in HCC.

31 March 2020

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Expression of Aurora A (but not Aurora B) is predictive of survival in breast cancer

31 March 2020

1 reference

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

31 March 2020

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The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation

31 March 2020

1 reference

Mitochondrial sirtuins and their relationships with metabolic disease and cancer

31 March 2020

1 reference

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

31 March 2020

1 reference

Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction

31 March 2020

1 reference

SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress

31 March 2020

1 reference

SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization

31 March 2020

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SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1.

31 March 2020

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Germline copy number variation of genes involved in chromatin remodelling in families suggestive of Li-Fraumeni syndrome with brain tumours.

31 March 2020

1 reference

Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer.

31 March 2020

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SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism

31 March 2020

1 reference

SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma

31 March 2020

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Diversity of gene expression in adenocarcinoma of the lung

31 March 2020

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A genomic analysis of adult T-cell leukemia

31 March 2020

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Upregulated INHBA expression is associated with poor survival in gastric cancer.

31 March 2020

1 reference

Bladder cancer outcome and subtype classification by gene expression

31 March 2020

1 reference

SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells

31 March 2020

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The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4

31 March 2020

1 reference

SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer.

31 March 2020

1 reference

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

31 March 2020

1 reference

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

31 March 2020

1 reference

Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6.

31 March 2020

1 reference

Chromatin and beyond: the multitasking roles for SIRT6

31 March 2020

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Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

31 March 2020

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The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

31 March 2020

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The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability

31 March 2020

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The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism

31 March 2020

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Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin.

31 March 2020

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Sirtuin-6-dependent genetic and epigenetic alterations are associated with poor clinical outcome in hepatocellular carcinoma patients

31 March 2020

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SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer.

31 March 2020

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The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses

31 March 2020

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Repression of RNA polymerase I upon stress is caused by inhibition of RNA-dependent deacetylation of PAF53 by SIRT7.

31 March 2020

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Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis

31 March 2020

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SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation

31 March 2020

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Understanding the Warburg effect: the metabolic requirements of cell proliferation

31 March 2020

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Interplay between sirtuins, MYC and hypoxia-inducible factor in cancer-associated metabolic reprogramming

31 March 2020

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Hypoxia-inducible factors and the response to hypoxic stress

31 March 2020

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Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation

31 March 2020

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Sirt3-mediated deacetylation of evolutionarily conserved lysine 122 regulates MnSOD activity in response to stress.

31 March 2020

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SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

31 March 2020

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Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents.

31 March 2020

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SIRT3-dependent GOT2 acetylation status affects the malate-aspartate NADH shuttle activity and pancreatic tumor growth

31 March 2020

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Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex

31 March 2020

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SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells.

31 March 2020

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31 March 2020

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MYC on the path to cancer

31 March 2020

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Sirt1 deacetylates c-Myc and promotes c-Myc/Max association

31 March 2020

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SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability

31 March 2020

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A c-Myc-SIRT1 feedback loop regulates cell growth and transformation.

31 March 2020

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The histone deacetylase SIRT2 stabilizes Myc oncoproteins

31 March 2020

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USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation

31 March 2020

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31 March 2020

USP10: friend and foe

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SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease

31 March 2020

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The DNA Damage Response: Making It Safe to Play with Knives

31 March 2020

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Genome maintenance mechanisms for preventing cancer

31 March 2020

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SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner

31 March 2020

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SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA

31 March 2020

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Regulation of global genome nucleotide excision repair by SIRT1 through xeroderma pigmentosum C

31 March 2020

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Defective mitophagy in XPA via PARP-1 hyperactivation and NAD(+)/SIRT1 reduction.

31 March 2020

1 reference

A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome

31 March 2020

1 reference

SIRT1 deacetylates TopBP1 and modulates intra-S-phase checkpoint and DNA replication origin firing

31 March 2020

1 reference

Playing the end game: DNA double-strand break repair pathway choice

31 March 2020

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The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

31 March 2020

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Mechanism of eukaryotic homologous recombination

31 March 2020

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SIRT1 contributes to telomere maintenance and augments global homologous recombination

31 March 2020

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SIRT1 regulates the function of the Nijmegen breakage syndrome protein

31 March 2020

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Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation

31 March 2020

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SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling

31 March 2020

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SIRT6 promotes DNA repair under stress by activating PARP1

31 March 2020

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Human SIRT6 promotes DNA end resection through CtIP deacetylation

31 March 2020

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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

31 March 2020

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SIRT1 promotes DNA repair activity and deacetylation of Ku70

31 March 2020

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SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair

31 March 2020

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Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1.

31 March 2020

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Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha

31 March 2020

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Inhibition of SIRT1 impairs the accumulation and transcriptional activity of HIF-1α protein under hypoxic conditions

31 March 2020

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Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

31 March 2020

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SIRT1 regulates endothelial Notch signaling in lung cancer

31 March 2020

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Sirtuin-7 inhibits the activity of hypoxia-inducible factors

31 March 2020

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SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis.

31 March 2020

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SIRT7 inactivation reverses metastatic phenotypes in epithelial and mesenchymal tumors

31 March 2020

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Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner

31 March 2020

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SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

31 March 2020

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Progression of chronic liver inflammation and fibrosis driven by activation of c-JUN signaling in Sirt6 mutant mice

31 March 2020

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Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

31 March 2020

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A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells

31 March 2020

1 reference

Sirtinol, a class III HDAC inhibitor, induces apoptotic and autophagic cell death in MCF-7 human breast cancer cells

31 March 2020

1 reference

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.

31 March 2020

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SIRT2 activity is required for the survival of C6 glioma cells

31 March 2020

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A novel sirtuin 2 (SIRT2) inhibitor with p53-dependent pro-apoptotic activity in non-small cell lung cancer

31 March 2020

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Making the best of PARP inhibitors in ovarian cancer

31 March 2020

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A new role for a yeast transcriptional silencer gene, SIR2, in regulation of recombination in ribosomal DNA.

31 March 2020

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Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast

31 March 2020

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Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern

31 March 2020

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Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae

31 March 2020

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Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.

31 March 2020

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Extrachromosomal rDNA circles--a cause of aging in yeast

31 March 2020

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

31 March 2020

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Sirtuins as regulators of metabolism and healthspan

31 March 2020

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The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

31 March 2020

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Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin

31 March 2020

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SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation

31 March 2020

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Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase

31 March 2020

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The SirT3 divining rod points to oxidative stress

31 March 2020

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Sirt3 promotes the urea cycle and fatty acid oxidation during dietary restriction

31 March 2020

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Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation

31 March 2020

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SIRT4 represses peroxisome proliferator-activated receptor α activity to suppress hepatic fat oxidation

31 March 2020

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SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase

31 March 2020

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Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity

31 March 2020

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The first identification of lysine malonylation substrates and its regulatory enzyme

31 March 2020

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SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways

31 March 2020

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SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks

31 March 2020

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Lysine glutarylation is a protein posttranslational modification regulated by SIRT5

31 March 2020

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SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target

31 March 2020

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The sirtuin SIRT6 regulates lifespan in male mice

31 March 2020

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A SIRT7-dependent acetylation switch of GABPβ1 controls mitochondrial function

31 March 2020

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SIRT7 controls hepatic lipid metabolism by regulating the ubiquitin-proteasome pathway.

31 March 2020

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Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice

31 March 2020

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On respiratory impairment in cancer cells

31 March 2020

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12 December 2020

Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress

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12 December 2020

SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice

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12 December 2020

Sir2 links chromatin silencing, metabolism, and aging

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12 December 2020

Identifiers

DOI

10.1038/NRC3985

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Dimensions Publication ID

2 August 2017

1038813311

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