(Q36436005)

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The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses

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scholarly article

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Europe PubMed Central

PMC publication ID

14 August 2017

The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses (English)

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Europe PubMed Central

PMC publication ID

14 August 2017

pancreatic cancer

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5

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Laura Sturla

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Europe PubMed Central

PMC publication ID

14 August 2017

Santina Bruzzone

17

object named as

Santina Bruzzone

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14 August 2017

author name string

Inga Bauer

1

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Europe PubMed Central

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14 August 2017

Alessia Grozio

2

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14 August 2017

Denise Lasigliè

3

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14 August 2017

Giovanna Basile

4

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14 August 2017

Mirko Magnone

6

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Europe PubMed Central

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14 August 2017

Giovanna Sociali

7

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14 August 2017

Debora Soncini

8

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14 August 2017

Irene Caffa

9

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Europe PubMed Central

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14 August 2017

Alessandro Poggi

10

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14 August 2017

Gabriele Zoppoli

11

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14 August 2017

Michele Cea

12

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Europe PubMed Central

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14 August 2017

Georg Feldmann

13

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14 August 2017

Raul Mostoslavsky

14

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Europe PubMed Central

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14 August 2017

Alberto Ballestrero

15

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14 August 2017

Franco Patrone

16

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14 August 2017

Alessio Nencioni

18

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14 August 2017

language of work or name

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publication date

18 October 2012

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14 August 2017

number of pages

14

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Journal of Biological Chemistry

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14 August 2017

287

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14 August 2017

49

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Europe PubMed Central

PMC publication ID

14 August 2017

40924-40937

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

NAD+ levels control Ca2+ store replenishment and mitogen-induced increase of cytosolic Ca2+ by Cyclic ADP-ribose-dependent TRPM2 channel gating in human T lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction

1 reference

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Cancer-related inflammation: common themes and therapeutic opportunities

1 reference

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30 September 2017

Targeting protein synthesis in a Myc/mTOR-driven model of anorexia-cachexia syndrome delays its onset and prolongs survival

1 reference

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30 September 2017

Activation of Sirt1 by resveratrol inhibits TNF-α induced inflammation in fibroblasts

1 reference

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30 September 2017

The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase

1 reference

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30 September 2017

Orphan macrodomain protein (human C6orf130) is an O-acyl-ADP-ribose deacylase: solution structure and catalytic properties

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

Cyclic ADP-ribose and NAADP: fraternal twin messengers for calcium signaling

1 reference

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30 September 2017

Calcium in tumour metastasis: new roles for known actors.

1 reference

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30 September 2017

Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes

1 reference

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30 September 2017

SIRT6 promotes DNA repair under stress by activating PARP1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

IL-8 signaling plays a critical role in the epithelial-mesenchymal transition of human carcinoma cells

1 reference

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30 September 2017

The role of chemokines and their receptors in angiogenesis

1 reference

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30 September 2017

Hallmarks of Cancer: The Next Generation

1 reference

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30 September 2017

Structure and biochemical functions of SIRT6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

Human SIRT6 promotes DNA end resection through CtIP deacetylation

1 reference

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30 September 2017

NFAT, immunity and cancer: a transcription factor comes of age

1 reference

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30 September 2017

Pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

Review: NAD +: a modulator of immune functions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

Function and metabolism of sirtuin metabolite O-acetyl-ADP-ribose

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

Functional dissection of SIRT6: identification of domains that regulate histone deacetylase activity and chromatin localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

Catastrophic NAD+ depletion in activated T lymphocytes through Nampt inhibition reduces demyelination and disability in EAE.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

The type III histone deacetylase Sirt1 is essential for maintenance of T cell tolerance in mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

Recent progress in the biology and physiology of sirtuins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment

1 reference

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30 September 2017

Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

CXCL8/IL-8 and CXCL12/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

1 reference

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30 September 2017

Pharmacological inhibition of nicotinamide phosphoribosyltransferase/visfatin enzymatic activity identifies a new inflammatory pathway linked to NAD

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

Anti-tumor necrosis factor therapy inhibits pancreatic tumor growth and metastasis

1 reference

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30 September 2017

Signaling properties of CD38 in the mouse immune system: enzyme-dependent and -independent roles in immunity

1 reference

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30 September 2017

Regulation of calcium signalling by adenine-based second messengers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

30 September 2017

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6

1 reference

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ADP-ribosyl cyclases generate two unusual adenine homodinucleotides with cytotoxic activity on mammalian cells

1 reference

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30 September 2017

Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3510797

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FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis

1 reference

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Biosynthesis of diphosphopyridine nucleotide. II. Enzymatic aspects

1 reference

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Immortalization with telomerase of the Nestin-positive cells of the human pancreas

1 reference

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1 reference

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Chemistry of gene silencing: the mechanism of NAD+-dependent deacetylation reactions

1 reference

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The role of cytokines in cancer-related fatigue

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30 September 2017

ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology

1 reference

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Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8

1 reference

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1 reference

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30 September 2017

Tumor necrosis factor-alpha mRNA accumulation in human myelomonocytic cell lines. Role of transcriptional regulation by DNA sequence motifs and mRNA stabilization

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Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor

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30 September 2017

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1 reference

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1 reference

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21 September 2018

Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases

1 reference

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Cytokines in pancreatic carcinoma: correlation with phenotypic characteristics and prognosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23086953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolite of SIR2 reaction modulates TRPM2 ion channel

1 reference

https://pubmed.ncbi.nlm.nih.gov/23086953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of cytokines in cancer cachexia

1 reference

https://pubmed.ncbi.nlm.nih.gov/23086953

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M112.405837

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

ResearchGate publication ID

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