(Q38759482)

6 September 2017

Alpha-Synuclein as a Biomarker for Parkinson's Disease (English)

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6 September 2017

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Anzari Atik

1

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PubMed ID

26940058

6 September 2017

Tessandra Stewart

series ordinal

2

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PubMed ID

26940058

6 September 2017

Jing Zhang

series ordinal

3

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6 September 2017

3 March 2016

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6 September 2017

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6 September 2017

26

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6 September 2017

3

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6 September 2017

410-418

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The epidemiology of dementia associated with Parkinson disease

6 September 2017

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A systematic review of prevalence studies of dementia in Parkinson's disease

21 January 2018

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Total and Proteinase K-Resistant α-Synuclein Levels in Erythrocytes, Determined by their Ability to Bind Phospholipids, Associate with Parkinson's Disease

21 January 2018

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alpha-Synuclein gene duplication is present in sporadic Parkinson disease.

21 January 2018

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Saliva α-Synuclein and A High Extinction Coefficient Protein: A Novel Approach in Assessment Biomarkers of Parkinson's Disease.

21 January 2018

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Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission.

21 January 2018

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The role of G-protein-coupled receptor kinase 5 in pathogenesis of sporadic Parkinson's disease.

21 January 2018

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Differences in neuropathologic characteristics across the Lewy body dementia spectrum.

21 January 2018

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Red blood cells are the major source of alpha-synuclein in blood.

21 January 2018

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Multi-organ distribution of phosphorylated alpha-synuclein histopathology in subjects with Lewy body disorders

21 January 2018

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Olfactory bulb alpha-synucleinopathy has high specificity and sensitivity for Lewy body disorders

21 January 2018

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Submandibular gland biopsy for the diagnosis of Parkinson disease

21 January 2018

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Naturally occurring α-synuclein autoantibody levels are lower in patients with Parkinson disease

21 January 2018

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Alpha-synuclein structure, posttranslational modification and alternative splicing as aggregation enhancers

21 January 2018

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α-Synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration

21 January 2018

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Staging of brain pathology related to sporadic Parkinson's disease

21 January 2018

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Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology

21 January 2018

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Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease

21 January 2018

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Emerging role of neuronal exosomes in the central nervous system

21 January 2018

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Exosomal cell-to-cell transmission of alpha synuclein oligomers.

21 January 2018

1 reference

Epidemiology of Parkinson's disease

21 January 2018

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Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson's disease

21 January 2018

1 reference

Salivary α-synuclein and DJ-1: potential biomarkers for Parkinson's disease.

21 January 2018

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The expression of alpha-, beta-, and gamma-synucleins in olfactory mucosa from patients with and without neurodegenerative diseases

21 January 2018

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Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation

21 January 2018

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Plasma alpha-synuclein in patients with Parkinson's disease with and without treatment

21 January 2018

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Conformational properties of alpha-synuclein in its free and lipid-associated states

21 January 2018

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Clinical diagnostic criteria for dementia associated with Parkinson's disease

21 January 2018

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Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease.

21 January 2018

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Cardiac sympathetic denervation correlates with clinical and pathologic stages of Parkinson's disease

21 January 2018

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Diminished tyrosine hydroxylase immunoreactivity in the cardiac conduction system and myocardium in Parkinson's disease: an anatomical study

21 January 2018

1 reference

Αlpha-synuclein levels in blood plasma from LRRK2 mutation carriers

21 January 2018

1 reference

Accuracy of a panel of 5 cerebrospinal fluid biomarkers in the differential diagnosis of patients with dementia and/or parkinsonian disorders.

21 January 2018

1 reference

Oxidative stress induces amyloid-like aggregate formation of NACP/alpha-synuclein in vitro

21 January 2018

1 reference

Sydney Multicenter Study of Parkinson's disease: non-L-dopa-responsive problems dominate at 15 years

21 January 2018

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DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease

21 January 2018

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What features improve the accuracy of clinical diagnosis in Parkinson's disease: A clinicopathologic study

21 January 2018

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Improved accuracy of clinical diagnosis of Lewy body Parkinson's disease

21 January 2018

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Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

21 January 2018

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The precursor protein of non-A beta component of Alzheimer's disease amyloid is a presynaptic protein of the central nervous system

21 January 2018

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The native form of alpha-synuclein is not found in the cerebrospinal fluid of patients with Parkinson's disease or normal controls.

21 January 2018

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Parkinson's disease: clinical features and diagnosis

21 January 2018

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Neuropathology of sporadic Parkinson's disease: evaluation and changes of concepts

21 January 2018

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N-terminal region of alpha-synuclein is essential for the fatty acid-induced oligomerization of the molecules.

21 January 2018

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Alpha-synuclein pathology in the spinal cords of neurologically asymptomatic aged individuals

21 January 2018

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Parkinson's disease. First of two parts

21 January 2018

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Parkinson's disease. Second of two parts

21 January 2018

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Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms

21 January 2018

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Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

21 January 2018

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The plasma alpha-synuclein levels in patients with Parkinson's disease and multiple system atrophy.

21 January 2018

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Conserved C-terminal charge exerts a profound influence on the aggregation rate of α-synuclein

21 January 2018

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Aggregation promoting C-terminal truncation of alpha-synuclein is a normal cellular process and is enhanced by the familial Parkinson's disease-linked mutations

21 January 2018

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Plasma alpha-synuclein is decreased in subjects with Parkinson's disease.

21 January 2018

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Alpha-synuclein: from secretion to dysfunction and death

21 January 2018

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SNCA variant associated with Parkinson disease and plasma alpha-synuclein level

21 January 2018

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Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease

21 January 2018

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An alternatively spliced form of rodent alpha-synuclein forms intracellular inclusions in vitro: role of the carboxy-terminus in alpha-synuclein aggregation.

21 January 2018

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Alpha-synuclein in blood and brain from familial Parkinson disease with SNCA locus triplication

21 January 2018

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α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study

21 January 2018

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Molecular pathophysiology of Parkinson's disease

21 January 2018

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Parkinson disease affects peripheral sensory nerves in the pharynx

21 January 2018

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Expression of alpha-synuclein, a presynaptic protein implicated in Parkinson's disease, in erythropoietic lineage

21 January 2018

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Cerebrospinal fluid alpha-synuclein in neurodegenerative disorders-a marker of synapse loss?

21 January 2018

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Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease

21 January 2018

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Role of post-translational modifications in modulating the structure, function and toxicity of alpha-synuclein: implications for Parkinson's disease pathogenesis and therapies

21 January 2018

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Phosphorylation at Ser-129 but not the phosphomimics S129E/D inhibits the fibrillation of alpha-synuclein.

21 January 2018

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Elevated levels of α-synuclein oligomer in the cerebrospinal fluid of drug-naïve patients with Parkinson's disease

21 January 2018

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Cerebrospinal fluid lysosomal enzymes and alpha-synuclein in Parkinson's disease

21 January 2018

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Exposure to long chain polyunsaturated fatty acids triggers rapid multimerization of synucleins.

21 January 2018

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Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

21 January 2018

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MDS clinical diagnostic criteria for Parkinson's disease

21 January 2018

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A comparison between rectal and colonic biopsies to detect Lewy pathology in Parkinson's disease.

21 January 2018

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Authentically phosphorylated α-synuclein at Ser129 accelerates neurodegeneration in a rat model of familial Parkinson's disease.

21 January 2018

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How valid is the clinical diagnosis of Parkinson's disease in the community?

21 January 2018

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In vitro phosphorylation does not influence the aggregation kinetics of WT α-synuclein in contrast to its phosphorylation mutants

21 January 2018

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Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease.

21 January 2018

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Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression

21 January 2018

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Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson's disease.

21 January 2018

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Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease.

21 January 2018

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Parkinson's Disease: Genetics and Pathogenesis

21 January 2018

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Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells.

21 January 2018

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α-Synuclein and anti-α-synuclein antibodies in Parkinson's disease, atypical Parkinson syndromes, REM sleep behavior disorder, and healthy controls

21 January 2018

1 reference

Mild cognitive impairment in Parkinson's disease: subtypes and motor characteristics

21 January 2018

1 reference

Cheek cell-derived α-synuclein and DJ-1 do not differentiate Parkinson's disease from control

21 January 2018

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Phosphorylated α-synuclein in Parkinson's disease: correlation depends on disease severity

21 January 2018

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Decreased alpha-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson's disease.

21 January 2018

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Detection of elevated levels of α-synuclein oligomers in CSF from patients with Parkinson disease.

21 January 2018

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CSF α-synuclein improves diagnostic and prognostic performance of CSF tau and Aβ in Alzheimer's disease

21 January 2018

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Diagnosis and the premotor phase of Parkinson disease

21 January 2018

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Biophysical properties of the synucleins and their propensities to fibrillate: inhibition of alpha-synuclein assembly by beta- and gamma-synucleins

21 January 2018

1 reference

Phosphorylated α-synuclein in Parkinson's disease

21 January 2018

1 reference

Biomarkers of Parkinson's disease: current status and future perspectives

21 January 2018

1 reference

Detection of α-synuclein oligomers in red blood cells as a potential biomarker of Parkinson's disease.

21 January 2018

1 reference

Biopsies of olfactory epithelium in patients with Parkinson's disease.

21 January 2018

1 reference

Phosphorylation of α-synuclein upregulates tyrosine hydroxylase activity in MN9D cells

21 January 2018

1 reference

α-synuclein reactive antibodies as diagnostic biomarkers in blood sera of Parkinson's disease patients.

21 January 2018

1 reference

Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias

21 January 2018

1 reference

Neuropathology of dementia in Parkinson's disease: A prospective, community-based study

21 January 2018

1 reference

Skin nerve α-synuclein deposits: a biomarker for idiopathic Parkinson disease

21 January 2018

1 reference

Localization of phosphoneuroprotein 14 (PNP 14) and its mRNA expression in rat brain determined by immunocytochemistry and in situ hybridization

21 January 2018

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12 December 2020

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12 December 2020

Skin and platelet alpha-synuclein as peripheral biomarkers of Parkinson's disease

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12 December 2020

Total CSF α-synuclein is lower in de novo Parkinson patients than in healthy subjects

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12 December 2020

Association of cerebrospinal fluid β-amyloid 1-42, T-tau, P-tau181, and α-synuclein levels with clinical features of drug-naive patients with early Parkinson disease

1 reference

12 December 2020

Detection of oligomeric forms of alpha-synuclein protein in human plasma as a potential biomarker for Parkinson's disease

1 reference

12 December 2020

Alpha-synuclein immunoreactivity in minor salivary gland biopsies of Parkinson's disease patients

1 reference

12 December 2020

Oxidative stress-induced phosphorylation, degradation and aggregation of alpha-synuclein are linked to upregulated CK2 and cathepsin D

1 reference

12 December 2020

Neuropathology, biochemistry, and biophysics of alpha-synuclein aggregation

1 reference

12 December 2020

A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson's disease

1 reference

12 December 2020

1 reference

12 December 2020

Lewy body-type degeneration in cardiac plexus in Parkinson's and incidental Lewy body diseases

1 reference

12 December 2020

alpha-Synuclein is phosphorylated in synucleinopathy lesions

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12 December 2020

Neuropathology of Parkinson's disease

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12 December 2020

Parkinson's disease dementia: definitions, guidelines, and research perspectives in diagnosis

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12 December 2020

Accuracy of clinical diagnosis in parkinsonism--a prospective study

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12 December 2020

Pathological lesions in colonic biopsies during Parkinson's disease

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12 December 2020

Phosphorylation does not prompt, nor prevent, the formation of alpha-synuclein toxic species in a rat model of Parkinson's disease

1 reference

12 December 2020

Excess burden of constipation in Parkinson's disease: a pilot study

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12 December 2020

Identifiers

DOI

10.1111/BPA.12370

1 reference

6 September 2017

0 references

1 reference

PubMed ID

26940058