(Q38769771)

6 September 2017

title

New developments in flavivirus drug discovery (English)

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6 September 2017

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W Mei Kok

1

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6 September 2017

language of work or name

English

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publication date

11 March 2016

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Expert Opinion on Drug Discovery

6 September 2017

published in

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6 September 2017

volume

11

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6 September 2017

issue

5

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6 September 2017

page(s)

433-445

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The global distribution and burden of dengue

6 September 2017

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21 January 2018

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Interaction of Flaviviruses with Reproduction Inhibitors Binding in β-OG Pocket: Insights from Molecular Dynamics Simulations

21 January 2018

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Design, synthesis, optimization and antiviral activity of a class of hybrid dengue virus E protein inhibitors

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Synthesis and assessment of 4-aminotetrahydroquinazoline derivatives as tick-borne encephalitis virus reproduction inhibitors.

21 January 2018

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Antibody-dependent enhancement of dengue virus infection is inhibited by SA-17, a doxorubicin derivative

21 January 2018

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An analogue of the antibiotic teicoplanin prevents flavivirus entry in vitro

21 January 2018

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Genotype-specific neutralization and protection by antibodies against dengue virus type 3.

21 January 2018

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DENGUE VIRUS. Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers

21 January 2018

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Structure-Guided Design of an Anti-dengue Antibody Directed to a Non-immunodominant Epitope

21 January 2018

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Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions

21 January 2018

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Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate

21 January 2018

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Sulfated polysaccharide, curdlan sulfate, efficiently prevents entry/fusion and restricts antibody-dependent enhancement of dengue virus infection in vitro: a possible candidate for clinical application

21 January 2018

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Sulfated Escherichia coli K5 polysaccharide derivatives inhibit dengue virus infection of human microvascular endothelial cells by interacting with the viral envelope protein E domain III.

21 January 2018

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Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides

21 January 2018

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Changes in antiviral susceptibility to entry inhibitors and endocytic uptake of dengue-2 virus serially passaged in Vero or C6/36 cells

21 January 2018

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Exploiting herpes simplex virus entry for novel therapeutics

21 January 2018

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Identification of specific histidines as pH sensors in flavivirus membrane fusion

21 January 2018

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21 January 2018

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21 January 2018

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Structural optimization and de novo design of dengue virus entry inhibitory peptides

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Substrate specificity of recombinant dengue 2 virus NS2B-NS3 protease: influence of natural and unnatural basic amino acids on hydrolysis of synthetic fluorescent substrates.

21 January 2018

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Functional profiling of recombinant NS3 proteases from all four serotypes of dengue virus using tetrapeptide and octapeptide substrate libraries.

21 January 2018

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Cleavage preference distinguishes the two-component NS2B–NS3 serine proteinases of Dengue and West Nile viruses

21 January 2018

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New approaches to structure-based discovery of dengue protease inhibitors

21 January 2018

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Potent cationic inhibitors of West Nile virus NS2B/NS3 protease with serum stability, cell permeability and antiviral activity

21 January 2018

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Peptide inhibitors of dengue virus NS3 protease. Part 2: SAR study of tetrapeptide aldehyde inhibitors.

21 January 2018

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Tripeptide inhibitors of dengue and West Nile virus NS2B-NS3 protease

21 January 2018

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Retro peptide-hybrids as selective inhibitors of the Dengue virus NS2B-NS3 protease.

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2016.1160887

Dual inhibitors of the dengue and West Nile virus NS2B-NS3 proteases: Synthesis, biological evaluation and docking studies of novel peptide-hybrids

21 January 2018

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Discovery of Nanomolar Dengue and West Nile Virus Protease Inhibitors Containing a 4-Benzyloxyphenylglycine Residue

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2016.1160887

Probing the substrate specificity of the dengue virus type 2 NS3 serine protease by using internally quenched fluorescent peptides

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2016.1160887

Development and characterization of new peptidomimetic inhibitors of the West Nile virus NS2B-NS3 protease

21 January 2018

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Phenylalanine and Phenylglycine Analogues as Arginine Mimetics in Dengue Protease Inhibitors

21 January 2018

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Critical effect of peptide cyclization on the potency of peptide inhibitors against Dengue virus NS2B-NS3 protease

21 January 2018

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https://api.crossref.org/works/10.1517%2F17460441.2016.1160887

Antiviral resistance and the future landscape of hepatitis C virus infection therapy

21 January 2018

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Design and evaluation of substrate-based octapeptide and non substrate-based tetrapeptide inhibitors of dengue virus NS2B-NS3 proteases

21 January 2018

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Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus

21 January 2018

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Synthesis and in vitro evaluation of West Nile virus protease inhibitors based on the 2-{6-[2-(5-phenyl-4H-{1,2,4]triazol-3-ylsulfanyl)acetylamino]benzothiazol-2-ylsulfanyl}acetamide scaffold

21 January 2018

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A small molecule inhibitor of dengue virus type 2 protease inhibits the replication of all four dengue virus serotypes in cell culture

21 January 2018

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Towards the design of antiviral inhibitors against flaviviruses: the case for the multifunctional NS3 protein from Dengue virus as a target

21 January 2018

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Structure of the Flavivirus helicase: implications for catalytic activity, protein interactions, and proteolytic processing

21 January 2018

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The NS 3 nonstructural protein of flaviviruses contains an RNA triphosphatase activity

21 January 2018

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Mutagenesis of the Dengue virus type 2 NS3 protein within and outside helicase motifs: effects on enzyme activity and virus replication

21 January 2018

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Discovering new medicines targeting helicases: challenges and recent progress

21 January 2018

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Ivermectin is a potent inhibitor of flavivirus replication specifically targeting NS3 helicase activity: new prospects for an old drug

21 January 2018

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Use of parallel validation high-throughput screens to reduce false positives and identify novel dengue NS2B-NS3 protease inhibitors

21 January 2018

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Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase

21 January 2018

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Update on new antivirals under development for the treatment of double-stranded DNA virus infections

21 January 2018

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Suramin inhibits helicase activity of NS3 protein of dengue virus in a fluorescence-based high throughput assay format

21 January 2018

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Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase

21 January 2018

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The phylogeny of RNA-dependent RNA polymerases of positive-strand RNA viruses

21 January 2018

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Computer-assisted identification of a putative methyltransferase domain in NS5 protein of flaviviruses and lambda 2 protein of reovirus

21 January 2018

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Biochemical and genetic characterization of dengue virus methyltransferase

21 January 2018

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Rational design of a live attenuated dengue vaccine: 2'-o-methyltransferase mutants are highly attenuated and immunogenic in mice and macaques

21 January 2018

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Small Molecule Inhibitors That Selectively Block Dengue Virus Methyltransferase

21 January 2018

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Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine

21 January 2018

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Refolding of a fully functional flavivirus methyltransferase revealed that S-adenosyl methionine but not S-adenosyl homocysteine is copurified with flavivirus methyltransferase

21 January 2018

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Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase

21 January 2018

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A crystal structure of the Dengue virus NS5 protein reveals a novel inter-domain interface essential for protein flexibility and virus replication

21 January 2018

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Structural and Functional Analyses of a Conserved Hydrophobic Pocket of Flavivirus Methyltransferase

21 January 2018

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Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery

21 January 2018

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Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)

21 January 2018

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A high-throughput screening assay for the identification of flavivirus NS5 capping enzyme GTP-binding inhibitors: implications for antiviral drug development

21 January 2018

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A scintillation proximity assay for dengue virus NS5 2'-O-methyltransferase-kinetic and inhibition analyses.

21 January 2018

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Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening.

21 January 2018

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Aptamer Displacement Screen for Flaviviral RNA Methyltransferase Inhibitors

21 January 2018

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The interface between methyltransferase and polymerase of NS5 is essential for flavivirus replication

21 January 2018

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Crystal Structure of the full-length Japanese encephalitis virus NS5 reveals a conserved methyltransferase-polymerase interface

21 January 2018

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Perturbation in the conserved methyltransferase-polymerase interface of flavivirus NS5 differentially affects polymerase initiation and elongation

21 January 2018

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Rational design of a flavivirus vaccine by abolishing viral RNA 2'-O methylation

21 January 2018

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Antiviral agents acting as DNA or RNA chain terminators

21 January 2018

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In search of flavivirus inhibitors: evaluation of different tritylated nucleoside analogues

21 January 2018

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In search of Flavivirus inhibitors part 2: tritylated, diphenylmethylated and other alkylated nucleoside analogues

21 January 2018

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3',5'Di-O-trityluridine inhibits in vitro flavivirus replication

21 January 2018

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Nucleoside inhibitors of tick-borne encephalitis virus

21 January 2018

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An adenosine nucleoside inhibitor of dengue virus

21 January 2018

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Cell entry and export of nucleoside analogues

21 January 2018

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Inhibition of dengue virus by an ester prodrug of an adenosine analog

21 January 2018

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The novel nucleoside analog R1479 (4'-azidocytidine) is a potent inhibitor of NS5B-dependent RNA synthesis and hepatitis C virus replication in cell culture

21 January 2018

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A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients

21 January 2018

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Randomised trial of interferon alpha2b plus ribavirin for 48 weeks or for 24 weeks versus interferon alpha2b plus placebo for 48 weeks for treatment of chronic infection with hepatitis C virus. International Hepatitis Interventional Therapy Group (I

21 January 2018

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Broad-spectrum inhibitor of viruses in the Flaviviridae family

21 January 2018

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Combined treatment of adenosine nucleoside inhibitor NITD008 and histone deacetylase inhibitor vorinostat represents an immunotherapy strategy to ameliorate West Nile virus infection

21 January 2018

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Small molecule drug discovery for Dengue and West Nile viruses: applying experience from hepatitis C virus

21 January 2018

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Enzymatic characterization and homology model of a catalytically active recombinant West Nile virus NS3 protease

21 January 2018

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Mouse models of dengue virus infection for vaccine testing

21 January 2018

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Animal models for studying dengue pathogenesis and therapy

21 January 2018

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Ten years of dengue drug discovery: progress and prospects

21 January 2018

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10.1517/17460441.2016.1160887

21 January 2018

Identifiers

DOI

1 reference

6 September 2017

1 reference