(Q38784278)

6 September 2017

1 reference

title

Mosaicism in health and disease - clones picking up speed (English)

1 reference

6 September 2017

David Gisselsson

2

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Lars A Forsberg

object named as

Lars A Forsberg

series ordinal

1

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Jan Dumański

object named as

Jan P Dumanski

series ordinal

3

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publication date

12 December 2016

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6 September 2017

published in

Nature Reviews Genetics

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6 September 2017

volume

18

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6 September 2017

issue

2

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6 September 2017

page(s)

128-142

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Clinical significance of chimerism

6 September 2017

cites work

1 reference

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Post-zygotic Point Mutations Are an Underrecognized Source of De Novo Genomic Variation

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Rate, molecular spectrum, and consequences of human mutation

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Evolution of the mutation rate

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Non-heritable genetics of human disease: spotlight on post-zygotic genetic variation acquired during lifetime

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An estimation of the number of cells in the human body

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Rate of de novo mutations and the importance of father's age to disease risk

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De novo rates and selection of large copy number variation

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Characteristics of de novo structural changes in the human genome

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Telomere instability in the male germline.

21 January 2018

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Fetal microchimerism in women with breast cancer

21 January 2018

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Case-control study of fetal microchimerism and breast cancer

21 January 2018

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Fetal microchimerism and maternal health: a review and evolutionary analysis of cooperation and conflict beyond the womb

21 January 2018

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Chromosome instability is common in human cleavage-stage embryos.

21 January 2018

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Hepatocyte Ploidy in Regenerating Livers after Partial Hepatectomy, Drug-Induced Necrosis, and Cirrhosis

21 January 2018

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The fetal thymus has a unique genomic copy number profile resulting from physiological T cell receptor gene rearrangement

21 January 2018

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Aneuploidy, polyploidy and ploidy reversal in the liver

21 January 2018

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The repopulation potential of hepatocyte populations differing in size and prior mitotic expansion

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRG.2016.145

Hepatocyte transplantation into diseased mouse liver. Kinetics of parenchymal repopulation and identification of the proliferative capacity of tetraploid and octaploid hepatocytes

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRG.2016.145

Frequent aneuploidy among normal human hepatocytes

21 January 2018

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Single cell sequencing reveals low levels of aneuploidy across mammalian tissues

21 January 2018

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Somatic mutation in single human neurons tracks developmental and transcriptional history

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRG.2016.145

Mosaic copy number variation in human neurons

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRG.2016.145

Somatic retrotransposition alters the genetic landscape of the human brain

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRG.2016.145

Single-neuron sequencing analysis of L1 retrotransposition and somatic mutation in the human brain

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRG.2016.145

Genetics. Genome mosaicism--one human, multiple genomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Long Neural Genes Harbor Recurrent DNA Break Clusters in Neural Stem/Progenitor Cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

The origin, mechanisms, incidence and clinical consequences of chromosomal mosaicism in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Somatic mosaicism for copy-neutral loss of heterozygosity and DNA copy number variations in the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Extensive genetic variation in somatic human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Detectable clonal mosaicism and its relationship to aging and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Detectable clonal mosaicism from birth to old age and its relationship to cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Mutagenesis. Smoking is associated with mosaic loss of chromosome Y.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Profound parental bias associated with chromosome 14 acquired uniparental disomy indicates targeting of an imprinted locus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Characterization of large structural genetic mosaicism in human autosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Extensive Hidden Genomic Mosaicism Revealed in Normal Tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Female chromosome X mosaicism is age-related and preferentially affects the inactivated X chromosome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

The role of mutations in epigenetic regulators in myeloid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Association between large detectable clonal mosaicism and type 2 diabetes with vascular complications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Signatures of post-zygotic structural genetic aberrations in the cells of histologically normal breast tissue that can predispose to sporadic breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Chromosome translocations and covert leukemic clones are generated during normal fetal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

The influence of age on T cell generation and TCR diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

B-cell diversity decreases in old age and is correlated with poor health status

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Age-associated aneuploidy: loss of Y chromosome from human bone marrow cells with aging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Mosaic loss of chromosome Y is associated with common variation near TCL1A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Y chromosome structural and functional changes in human malignant diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Loss of Y-chromosome does not correlate with age at onset of head and neck carcinoma: a case-control study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Cancer cells preferentially lose small chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

The significance of isolated Y chromosome loss in bone marrow metaphase cells from males over age 50 years

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Male breast cancer, age and sex chromosome aneuploidy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Loss of Y Chromosome in Peripheral Blood of Colorectal and Prostate Cancer Patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

New data shed light on Y-loss-related pathogenesis in myelodysplastic syndromes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Increased loss of the Y chromosome in peripheral blood cells in male patients with autoimmune thyroiditis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Y chromosome loss in male patients with primary biliary cirrhosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Single-cell, genome-wide sequencing identifies clonal somatic copy-number variation in the human brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Cell lineage analysis in human brain using endogenous retroelements.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Single-cell genome sequencing: current state of the science

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Genetic variants regulating immune cell levels in health and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Single-cell sequencing-based technologies will revolutionize whole-organism science

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Mitotic recombination in patients with ichthyosis causes reversion of dominant mutations in KRT10

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Revertant mosaicism in junctional epidermolysis bullosa due to multiple correcting second-site mutations in LAMB3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Revertant mosaicism in human genetic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Revertant mutation releases confined lethal mutation, opening Pandora's box: a novel genetic pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Chromothriptic cure of WHIM syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Unique features of the transcriptional response to model aneuploidy in human cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Aneuploidy affects proliferation and spontaneous immortalization in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Chromosomal mosaicism in human preimplantation embryos: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Morphological and cytogenetic assessment of cleavage and blastocyst stage embryos

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Spontaneous abortion and confined chromosomal mosaicism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Confined placental mosaicism at chorionic villous sampling: risk factors and pregnancy outcome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Prenatal diagnosis of chromosomal mosaicism in over 1600 cases using array comparative genomic hybridization as a first line test.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

The distribution of chromosomal genotypes associated with Turner's syndrome: livebirth prevalence rates and evidence for diminished fetal mortality and severity in genotypes associated with structural X abnormalities or mosaicism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Parental origin of normal X chromosomes in Turner syndrome patients with various karyotypes: implications for the mechanism leading to generation of a 45,X karyotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Turner syndrome revisited: review of new data supports the hypothesis that all viable 45,X cases are cryptic mosaics with a rescue cell line, implying an origin by mitotic loss

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Cancer incidence in women with Turner syndrome in Great Britain: a national cohort study

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Buccal cell FISH and blood PCR-Y detect high rates of X chromosomal mosaicism and Y chromosomal derivatives in patients with Turner syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Y-chromosome markers in Turner syndrome: Screening of 130 patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

The proportion of diploid 46,XX cells increases with time in women with Turner syndrome--a 10-year follow-up study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

A sex-chromosome anomaly in a case of gonadal dysgenesis (Turner's syndrome).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Classification and biological nature of established human hematopoietic cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Growth of diploid, epstein-barr virus-carrying human lymphoblastoid cell lines heterotransplanted into nude mice under immunologically privileged conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Whole-exome sequencing of DNA from peripheral blood mononuclear cells (PBMC) and EBV-transformed lymphocytes from the same donor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Trisomy 7 in nonneoplastic cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Cross-Generational Reproductive Fitness Enforced by Microchimeric Maternal Cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Multi-lineage potential of fetal cells in maternal tissue: a legacy in reverse

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Distant mesenchymal progenitors contribute to skin wound healing and produce collagen: evidence from a murine fetal microchimerism model

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Fetal microchimerism as an explanation of disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Identification of fetal DNA and cells in skin lesions from women with systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Chimerism in monochorionic dizygotic twins: case study and review.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Transplanted bone marrow generates new neurons in human brains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

21 January 2018

Mosaics and chimaeras

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Mechanisms of mosaicism, chimerism and uniparental disomy identified by single nucleotide polymorphism array analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Somatic mosaicism for chromosome X and Y aneuploidies in monozygotic twins heterozygous for sickle cell disease mutation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Screening newborn blood spots for 22q11.2 deletion syndrome using multiplex droplet digital PCR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Somatic mosaicism in healthy human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

L1 retrotransposition can occur early in human embryonic development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

L1 retrotransposition in human neural progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Epigenetic control of retrotransposon expression in human embryonic stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

The evidence for increased L1 activity in the site of human adult brain neurogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

DNA instability in postmitotic neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Post-zygotic and inter-individual structural genetic variation in a presumptive enhancer element of the locus between the IL10Rβ and IFNAR1 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Nonhomologous DNA end joining (NHEJ) and chromosomal translocations in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Mechanisms of change in gene copy number

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Generation of trisomies in cancer cells by multipolar mitosis and incomplete cytokinesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Human chromosomes with shorter telomeres and large heterochromatin regions have a higher frequency of acquired somatic cell aneuploidy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

The origin and evolution of mutations in acute myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Detection of leukemia-associated mutations in peripheral blood DNA of hematologically normal elderly individuals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Change of Human Chromosome Count Distributions with Age: Evidence for a Sex Difference

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Cell Selection in vivo in Normal/G Trisomic Mosaics

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Structural genetic variation in the context of somatic mosaicism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Microchimerism of male origin in a cohort of Danish girls

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Multiplicative mononuclear small hepatocytes in adult rat liver: their isolation as a homogeneous population and localization to periportal zone

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Somatic mosaicism for copy number variation in differentiated human tissues

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Concurrent DNA Copy-Number Alterations and Mutations in Genes Related to Maintenance of Genome Stability in Uninvolved Mammary Glandular Tissue from Breast Cancer Patients

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Clinical significance of Y chromosome loss in hematologic disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Spontaneous in vivo reversion to normal of an inherited mutation in a patient with adenosine deaminase deficiency

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

FISH analysis on day 5 post‐insemination of human arrested and blastocyst stage embryos

31 March 2020

2 references

https://api.crossref.org/works/10.1038%2FNRG.2016.145

31 March 2020

12 December 2020

Twenty-four chromosome FISH in human IVF embryos reveals patterns of post-zygotic chromosome segregation and nuclear organisation

1 reference

https://api.crossref.org/works/10.1038%2FNRG.2016.145

Molecular genetic evidence of Y chromosome loss in male patients with hematological disorders

31 March 2020

1 reference

12 December 2020

Loss of the Y chromosome from normal and neoplastic bone marrows. United Kingdom Cancer Cytogenetics Group (UKCCG)

1 reference

12 December 2020

The frequency of aneuploidy in cultured lymphocytes is correlated with age and gender but not with reproductive history.

1 reference

12 December 2020

Mosaic autosomal trisomy in cultures from spontaneous abortions

1 reference

12 December 2020

Loss of the Y chromosome: an age-related or clonal phenomenon in acute myelogenous leukemia/myelodysplastic syndrome?

1 reference

12 December 2020

Non-Homologous Pairing and Crossing over in Drosophila Melanogaster

1 reference

12 December 2020

Meiotic origin of trisomy in confined placental mosaicism is correlated with presence of fetal uniparental disomy, high levels of trisomy in trophoblast, and increased risk of fetal intrauterine growth restriction

1 reference

12 December 2020

Merotelic kinetochore orientation versus chromosome mono-orientation in the origin of lagging chromosomes in human primary cells.

1 reference

12 December 2020

Disappearing mosaicism. Suggested mechanism is growth advantage of normal over abnormal cell population

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRG.2016.145

1 reference

Dimensions Publication ID

6 September 2017

1007392066

0 references

1 reference