(Q38787483)

English

Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors

scientific article published on 10 March 2016

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scholarly article

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Europe PubMed Central

PubMed publication ID

6 September 2017

Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors (English)

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Europe PubMed Central

PubMed publication ID

6 September 2017

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Martin Ingelsson

8

object named as

Martin Ingelsson

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Europe PubMed Central

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6 September 2017

6

object named as

Lars Lannfelt

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6 September 2017

author name string

Gabriel Gustafsson

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6 September 2017

Fredrik Eriksson

2

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6 September 2017

Christer Möller

3

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6 September 2017

Tomás Lopes da Fonseca

4

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Europe PubMed Central

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6 September 2017

Tiago F Outeiro

5

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6 September 2017

Joakim Bergström

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6 September 2017

publication date

10 March 2016

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6 September 2017

Cellular and Molecular Neurobiology

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6 September 2017

37

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1

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6 September 2017

121-131

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6 September 2017

Antibody-aided clearance of extracellular α-synuclein prevents cell-to-cell aggregate transmission

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Epitope and isotype specificities of antibodies to beta -amyloid peptide for protection against Alzheimer's disease-like neuropathology

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses.

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Alpha-synuclein locus duplication as a cause of familial Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Accumulation of toxic α-synuclein oligomer within endoplasmic reticulum occurs in α-synucleinopathy in vivo.

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Antibody uptake into neurons occurs primarily via clathrin-dependent Fcγ receptor endocytosis and is a prerequisite for acute tau protein clearance.

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Accelerated in vitro fibril formation by a mutant alpha-synuclein linked to early-onset Parkinson disease

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Different species of alpha-synuclein oligomers induce calcium influx and seeding.

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Seeding induced by alpha-synuclein oligomers provides evidence for spreading of alpha-synuclein pathology

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Exosomal cell-to-cell transmission of alpha synuclein oligomers.

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation.

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Monoclonal antibodies selective for α-synuclein oligomers/protofibrils recognize brain pathology in Lewy body disorders and α-synuclein transgenic mice with the disease-causing A30P mutation

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Distinct Therapeutic Mechanisms of Tau Antibodies: Promoting Microglial Clearance Versus Blocking Neuronal Uptake

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Reducing C-terminal-truncated alpha-synuclein by immunotherapy attenuates neurodegeneration and propagation in Parkinson's disease-like models

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly.

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Identification of two distinct synucleins from human brain

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Pre-fibrillar alpha-synuclein variants with impaired beta-structure increase neurotoxicity in Parkinson's disease models

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Intravesicular localization and exocytosis of alpha-synuclein and its aggregates.

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Alterations of Fc gamma receptor I and Toll-like receptor 4 mediate the antiinflammatory actions of microglia and astrocytes after adrenaline-induced blood-brain barrier opening in rats

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Immunotherapy targeting α-synuclein protofibrils reduced pathology in (Thy-1)-h[A30P] α-synuclein mice

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Immunotherapy targeting α-synuclein, with relevance for future treatment of Parkinson's disease and other Lewy body disorders

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Microglial internalization and degradation of pathological tau is enhanced by an anti-tau monoclonal antibody.

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Effects of alpha-synuclein immunization in a mouse model of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Passive immunization reduces behavioral and neuropathological deficits in an alpha-synuclein transgenic model of Lewy body disease

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Antibodies against alpha-synuclein reduce oligomerization in living cells

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Expression of Fc gamma receptors on astroglial cell lines and their role in the central nervous system

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Formation of toxic oligomeric alpha-synuclein species in living cells

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

The paradoxical cell biology of alpha-Synucle

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

ESCRT-mediated uptake and degradation of brain-targeted α-synuclein single chain antibody attenuates neuronal degeneration in vivo

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Robust amyloid clearance in a mouse model of Alzheimer's disease provides novel insights into the mechanism of amyloid-beta immunotherapy

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

In vivo demonstration that alpha-synuclein oligomers are toxic

1 reference

https://api.crossref.org/works/10.1007%2FS10571-016-0352-5

21 January 2018

Identifiers

10.1007/S10571-016-0352-5

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

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