(Q38792491)

6 September 2017

title

Retromer and Rab2-dependent trafficking mediate PS1 degradation by proteasomes in endocytic disturbance (English)

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6 September 2017

2

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6 September 2017

Naoya Ueda

1

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6 September 2017

Katsuhiko Yanagisawa

series ordinal

3

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6 September 2017

Nobuyuki Kimura

series ordinal

4

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6 September 2017

language of work or name

English

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publication date

20 February 2016

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Journal of Neurochemistry

6 September 2017

published in

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6 September 2017

volume

137

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6 September 2017

issue

4

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6 September 2017

page(s)

647-658

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Early-onset Alzheimer disease in an Italian family with presenilin-1 double mutation E318G and G394V.

6 September 2017

cites work

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The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport

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Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

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Retromer: a master conductor of endosome sorting

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Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain

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Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome.

21 January 2018

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Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates

21 January 2018

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Sorting nexins provide diversity for retromer-dependent trafficking events

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Commentary. Lysosomotropic agents

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Effects of exogenous amines on mammalian cells, with particular reference to membrane flow

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Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases

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Rab9 and retromer regulate retrograde trafficking of luminal protein required for epithelial tube length control

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

21 January 2018

1 reference

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

21 January 2018

1 reference

Evidence for a COP-I-independent transport route from the Golgi complex to the endoplasmic reticulum

21 January 2018

1 reference

Chloroquine inhibits lysosomal enzyme pinocytosis and enhances lysosomal enzyme secretion by impairing receptor recycling

21 January 2018

1 reference

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

21 January 2018

1 reference

Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production

21 January 2018

1 reference

Targeting of cell-surface beta-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments.

21 January 2018

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

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Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

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Endosomal accumulation of GM1 ganglioside-bound amyloid beta-protein in neurons of aged monkey brains.

21 January 2018

1 reference

Dynein dysfunction induces endocytic pathology accompanied by an increase in Rab GTPases: a potential mechanism underlying age-dependent endocytic dysfunction

21 January 2018

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Dynein dysfunction disrupts intracellular vesicle trafficking bidirectionally and perturbs synaptic vesicle docking via endocytic disturbances a potential mechanism underlying age-dependent impairment of cognitive function

21 January 2018

1 reference

BACE is degraded via the lysosomal pathway

21 January 2018

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Cross-linking of cell surface amyloid precursor protein leads to increased β-amyloid peptide production in hippocampal neurons: implications for Alzheimer's disease

21 January 2018

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Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

21 January 2018

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GTP-bound forms of rab6 induce the redistribution of Golgi proteins into the endoplasmic reticulum

21 January 2018

1 reference

Pathways towards and away from Alzheimer's disease

21 January 2018

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Regulation of membrane transport through the endocytic pathway by rabGTPases

21 January 2018

1 reference

Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation

21 January 2018

1 reference

Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a γ-secretase-independent manner

21 January 2018

1 reference

Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases

21 January 2018

1 reference

Autophagy, amyloidogenesis and Alzheimer disease

21 January 2018

1 reference

Assembly and solution structure of the core retromer protein complex

21 January 2018

1 reference

Proteomic identification of sorting nexin 6 as a negative regulator of BACE1-mediated APP processing.

21 January 2018

1 reference

Multiple routes of protein transport from endosomes to the trans Golgi network

21 January 2018

1 reference

High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease.

21 January 2018

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Distinctive inhibition of the lysosomal targeting of lysozyme and cathepsin D by drugs affecting pH gradients and protein kinase C

21 January 2018

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Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway.

21 January 2018

1 reference

Lysosome biogenesis requires Rab9 function and receptor recycling from endosomes to the trans-Golgi network

21 January 2018

1 reference

The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

21 January 2018

1 reference

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

21 January 2018

1 reference

Recycle your receptors with retromer

21 January 2018

1 reference

Endosome protein sorting: motifs and machinery

21 January 2018

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The molecular pathology of Alzheimer's disease

21 January 2018

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Genome-wide analysis of genetic loci associated with Alzheimer disease

21 January 2018

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

21 January 2018

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FAD mutants unable to increase neurotoxic Aβ 42 suggest that mutation effects on neurodegeneration may be independent of effects on Aβ

21 January 2018

1 reference

gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in?

21 January 2018

1 reference

Model-guided microarray implicates the retromer complex in Alzheimer's disease

21 January 2018

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Expression of beta-amyloid precursor protein-CD3gamma chimeras to demonstrate the selective generation of amyloid beta(1-40) and amyloid beta(1-42) peptides within secretory and endocytic compartments

21 January 2018

1 reference

Syntaxin 5 interacts specifically with presenilin holoproteins and affects processing of betaAPP in neuronal cells

21 January 2018

1 reference

Genomic convergence and network analysis approach to identify candidate genes in Alzheimer's disease

21 January 2018

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Rab2 is essential for the maturation of pre-Golgi intermediates

21 January 2018

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Rab2 protein enhances coatomer recruitment to pre-Golgi intermediates

21 January 2018

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Rab2 utilizes glyceraldehyde-3-phosphate dehydrogenase and protein kinase C{iota} to associate with microtubules and to recruit dynein

21 January 2018

1 reference

A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production

21 January 2018

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Intra-endosomal membrane traffic

21 January 2018

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Identification of Alzheimer disease-associated variants in genes that regulate retromer function

21 January 2018

1 reference

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

21 January 2018

1 reference

VPS35 haploinsufficiency increases Alzheimer's disease neuropathology.

21 January 2018

1 reference

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

21 January 2018

1 reference

A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.

21 January 2018

1 reference

Genetics of Alzheimer’s Disease

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/JNC.13586

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6 September 2017

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