(Q38793023)

6 September 2017

title

Immune responses to endogenous retroelements: taking the bad with the good (English)

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6 September 2017

2

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6 September 2017

George Kassiotis

1

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6 September 2017

publication date

1 March 2016

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Nature Reviews Immunology

6 September 2017

published in

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6 September 2017

volume

16

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6 September 2017

issue

4

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6 September 2017

page(s)

207-219

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The immune system: a weapon of mass destruction invented by evolution to even the odds during the war of the DNAs

6 September 2017

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Identification of an infectious progenitor for the multiple-copy HERV-K human endogenous retroelements

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Reconstitution of an infectious human endogenous retrovirus

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Keeping active endogenous retroviral-like elements in check: the epigenetic perspective

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Dynamic control of endogenous retroviruses during development.

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Molecular mechanisms mediated by human endogenous retroviruses (HERVs) in autoimmunity

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Role of endogenous retroviruses in murine SLE.

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Active human retrotransposons: variation and disease

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Endogenous retroviruses and the development of cancer

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Endogenous retroviral pathogenesis in lupus

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Endogenous retroviruses and cancer

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The enemy within: endogenous retroelements and autoimmune disease

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The diversity of retrotransposons and the properties of their reverse transcriptases

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The Influence of LINE-1 and SINE Retrotransposons on Mammalian Genomes

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Hot L1s account for the bulk of retrotransposition in the human population

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Human transposon tectonics

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Retrotransposons Revisited: The Restraint and Rehabilitation of Parasites

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L1 retrotransposons and somatic mosaicism in the brain.

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Landscape of somatic retrotransposition in human cancers

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Retrotransposition and Crystal Structure of an Alu RNP in the Ribosome-Stalling Conformation

21 January 2018

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Characterisation of cytoplasmic DNA complementary to non-retroviral RNA viruses in human cells

21 January 2018

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Long terminal repeat retrotransposons of Mus musculus

21 January 2018

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Human Endogenous Retrovirus Type K (HERV-K) Particles Package and Transmit HERV-K-Related Sequences

21 January 2018

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Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors

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Env-less endogenous retroviruses are genomic superspreaders

21 January 2018

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Microarray analysis reveals global modulation of endogenous retroelement transcription by microbes.

21 January 2018

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Environmental epigenomics and disease susceptibility

21 January 2018

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Genome-wide B1 retrotransposon binds the transcription factors dioxin receptor and Slug and regulates gene expression in vivo

21 January 2018

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Induction of long interspersed nucleotide element-1 (L1) retrotransposition by 6-formylindolo[3,2- b ]carbazole (FICZ), a tryptophan photoproduct

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2016.27

Long interspersed element-1 is differentially regulated by food-borne carcinogens via the aryl hydrocarbon receptor

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2016.27

Normal B-cell activation involves endogenous retroviral antigen expression: implications for leukemogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2016.27

Endogenous retrovirus expression in stimulated murine lymphocytes. Identification of a new locus controlling mitogen induction of a defective virus

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2016.27

The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2016.27

RETRACTED: MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2016.27

The Ro60 autoantigen binds endogenous retroelements and regulates inflammatory gene expression

21 January 2018

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Nucleic acid recognition by the innate immune system

21 January 2018

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Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication

21 January 2018

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A Tlr7 translocation accelerates systemic autoimmunity in murine lupus

21 January 2018

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RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

21 January 2018

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Emerging roles of TLR7 and TLR9 in murine SLE.

21 January 2018

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Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

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DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts.

21 January 2018

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Aicardi-Goutieres syndrome and related phenotypes: linking nucleic acid metabolism with autoimmunity

21 January 2018

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Gain-of-function mutations in IFIH1 cause a spectrum of human disease phenotypes associated with upregulated type I interferon signaling

21 January 2018

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Trex1 prevents cell-intrinsic initiation of autoimmunity

21 January 2018

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Modulation of LINE-1 and Alu/SVA retrotransposition by Aicardi-Goutières syndrome-related SAMHD1.

21 January 2018

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MOV10 RNA helicase is a potent inhibitor of retrotransposition in cells

21 January 2018

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Endogenous MOV10 inhibits the retrotransposition of endogenous retroelements but not the replication of exogenous retroviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

The Broad-Spectrum Antiviral Protein ZAP Restricts Human Retrotransposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

The Zinc-Finger Antiviral Protein ZAP Inhibits LINE and Alu Retrotransposition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

RNase L restricts the mobility of engineered retrotransposons in cultured human cells

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2016.27

The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

An autoimmune disease prevented by anti-retroviral drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Genome-derived cytosolic DNA mediates type I interferon-dependent rejection of B cell lymphoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Mitochondrial DNA stress primes the antiviral innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Nucleoside reverse transcriptase inhibitors possess intrinsic anti-inflammatory activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Negative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Mouse mammary tumor virus molecular biology and oncogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Murine Vbeta3+ and Vbeta7+ T cell subsets are specific targets for the HERV-K18 Env superantigen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Vaccination with cancer- and HIV infection-associated endogenous retrotransposable elements is safe and immunogenic

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Regulation of the human endogenous retrovirus K (HML-2) transcriptome by the HIV-1 Tat protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Loss of epigenetic silencing in tumors preferentially affects primate-specific retroelements

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Human endogenous retrovirus K and cancer: Innocent bystander or tumorigenic accomplice?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Recent developments linking retroviruses to human breast cancer: infectious agent, enemy within or both?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Endogenous retroviruses as targets for antitumor immunity in renal cell cancer and other tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

The mouse mammary tumor virus env gene is the source of a CD8+ T-cell-stimulating peptide presented by a major histocompatibility complex class I molecule in a murine thymoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Endogenous retroviral LTRs as promoters for human genes: a critical assessment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Distinct isoform of FABP7 revealed by screening for retroelement-activated genes in diffuse large B-cell lymphoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

An alternative exon 1 of the CD5 gene regulates CD5 expression in human B lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

KMT1E-mediated chromatin modifications at the FcγRIIb promoter regulate thymocyte development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Nucleic Acid-Sensing Receptors: Rheostats of Autoimmunity and Autoinflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Endogenous MMTV proviruses induce susceptibility to both viral and bacterial pathogens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Agonist ligands expressed by thymic epithelium enhance positive selection of regulatory T lymphocytes from precursors with a normally diverse TCR repertoire

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Regulatory T-cell expansion during chronic viral infection is dependent on endogenous retroviral superantigens

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

IL-2-independent and TNF-α-dependent expansion of Vβ5+ natural regulatory T cells during retrovirus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Retroviral infection in vivo requires an immune escape virulence factor encrypted in the envelope protein of oncoretroviruses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2016.27

Human endogenous retrovirus-K contributes to motor neuron disease.

21 January 2018

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Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells

21 January 2018

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The cup runneth over: lessons from the ever-expanding pool of primary immunodeficiency diseases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2016.27

Pathogenic Mechanisms of HIV Disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2016.27

How the TCR balances sensitivity and specificity for the recognition of self and pathogens.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Initial sequencing and analysis of the human genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Initial sequencing and comparative analysis of the mouse genome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

SVA retrotransposons: Evolution and genetic instability

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2016.27

Mammalian Endogenous Retroviruses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Studies of endogenous retroviruses reveal a continuing evolutionary saga

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRI.2016.27

Origin and evolution of retroelements based upon their reverse transcriptase sequences

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI.2016.27

31 March 2020

12 December 2020

Phenotypic Mixing of Retroviruses in Mitogen-stimulated Lymphocytes: Analysis of Xenotropic and Defective Endogenous Mouse Viruses

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https://api.crossref.org/works/10.1038%2FNRI.2016.27

Resurrection of endogenous retroviruses in antibody-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

APOBEC3A deaminates transiently exposed single-strand DNA during LINE-1 retrotransposition

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Potential target antigens for immunotherapy in human pancreatic cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRI.2016.27

Repetitive DNA and next-generation sequencing: computational challenges and solutions

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRI.2016.27

A human endogenous retroviral sequence encoding an antigen recognized on melanoma by cytolytic T lymphocytes.

31 March 2020

1 reference

PubMed

12 December 2020

Immunization against endogenous retroviral tumor-associated antigens.

1 reference

PubMed

12 December 2020

Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells

1 reference

PubMed

12 December 2020

Identifiers

DOI

10.1038/NRI.2016.27

1 reference

6 September 2017

1 reference