(Q37977320)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22261968%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

title

How the TCR balances sensitivity and specificity for the recognition of self and pathogens (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22261968%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22261968%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

author name string

Paul M Allen

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22261968%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

language of work or name

English

0 references

publication date

19 January 2012

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22261968%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22261968%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

volume

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22261968%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

issue

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22261968%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

page(s)

121-128

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22261968%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference

Navigating the network: signaling cross-talk in hematopoietic cells.

21 January 2018

1 reference

Specific recognition of thymic self-peptides induces the positive selection of cytotoxic T lymphocytes

21 January 2018

1 reference

An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells

21 January 2018

1 reference

An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a

21 January 2018

1 reference

T cell receptor antagonist peptides induce positive selection

21 January 2018

1 reference

How TCRs bind MHCs, peptides, and coreceptors

21 January 2018

1 reference

The MHC reactivity of the T cell repertoire prior to positive and negative selection.

21 January 2018

1 reference

Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon'

21 January 2018

1 reference

Crossreactive T Cells Spotlight the Germline Rules for αβ T Cell-Receptor Interactions with MHC Molecules

21 January 2018

1 reference

Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection

21 January 2018

1 reference

Alloreactivity is limited by the endogenous peptide repertoire

21 January 2018

1 reference

A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers

21 January 2018

1 reference

Two-step binding mechanism for T-cell receptor recognition of peptide MHC.

21 January 2018

1 reference

Alloreactive T cells respond specifically to multiple distinct peptide-MHC complexes

21 January 2018

1 reference

The molecular basis of TCR germline bias for MHC is surprisingly simple

21 January 2018

1 reference

How the T Cell Repertoire Becomes Peptide and MHC Specific

21 January 2018

1 reference

Low Affinity Interaction of Peptide-MHC Complexes with T Cell Receptors

21 January 2018

1 reference

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness.

21 January 2018

1 reference

TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity.

21 January 2018

1 reference

Mature T cell reactivity altered by peptide agonist that induces positive selection

21 January 2018

1 reference

Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation

21 January 2018

1 reference

Partially phosphorylated T cell receptor zeta molecules can inhibit T cell activation

21 January 2018

1 reference

The functional network of ion channels in T lymphocytes

21 January 2018

1 reference

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

21 January 2018

1 reference

Three-dimensional segregation of supramolecular activation clusters in T cells

21 January 2018

1 reference

The immunological synapse: a molecular machine controlling T cell activation

21 January 2018

1 reference

New insights into the T cell synapse from single molecule techniques

21 January 2018

1 reference

T cell receptor ligation induces the formation of dynamically regulated signaling assemblies

21 January 2018

1 reference

T-cell triggering thresholds are modulated by the number of antigen within individual T-cell receptor clusters

21 January 2018

1 reference

Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity

21 January 2018

1 reference

Evidence for a functional sidedness to the alphabetaTCR.

21 January 2018

1 reference

Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality

21 January 2018

1 reference

Actin and agonist MHC-peptide complex-dependent T cell receptor microclusters as scaffolds for signaling

21 January 2018

1 reference

Newly generated T cell receptor microclusters initiate and sustain T cell activation by recruitment of Zap70 and SLP-76.

21 January 2018

1 reference

TCR and Lat are expressed on separate protein islands on T cell membranes and concatenate during activation.

21 January 2018

1 reference

Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapse

21 January 2018

1 reference

Selective modulation of protein kinase C-theta during T-cell activation

21 January 2018

1 reference

Spatiotemporal regulation of T cell costimulation by TCR-CD28 microclusters and protein kinase C theta translocation

21 January 2018

1 reference

T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand.

21 January 2018

1 reference

T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation cluster

21 January 2018

1 reference

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling

21 January 2018

1 reference

The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse

21 January 2018

1 reference

Unique features of the pre-T-cell receptor alpha-chain: not just a surrogate

21 January 2018

1 reference

Regulation of lymphoid development, differentiation, and function by the Notch pathway.

21 January 2018

1 reference

Launching the T-cell-lineage developmental programme

21 January 2018

1 reference

Analysis and expression of a cloned pre-T cell receptor gene

21 January 2018

1 reference

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

21 January 2018

1 reference

Pre-TCRalpha and TCRalpha are not interchangeable partners of TCRbeta during T lymphocyte development

21 January 2018

1 reference

Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation

21 January 2018

1 reference

Thymocyte development in the absence of pre-T cell receptor extracellular immunoglobulin domains

21 January 2018

1 reference

A critical role for the cytoplasmic tail of pTα in T lymphocyte development

21 January 2018

1 reference

The thymus has two functionally distinct populations of immature alpha beta + T cells: one population is deleted by ligation of alpha beta TCR.

21 January 2018

1 reference

Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand.

21 January 2018

1 reference

T-cell-receptor affinity and thymocyte positive selection

21 January 2018

1 reference

A kinetic threshold between negative and positive selection based on the longevity of the T cell receptor-ligand complex

21 January 2018

1 reference

A constant affinity threshold for T cell tolerance

21 January 2018

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The repertoire of T cells shaped by a single MHC/peptide ligand.

21 January 2018

1 reference

A single peptide-MHC complex positively selects a diverse and specific CD8 T cell repertoire

21 January 2018

1 reference

Preselection thymocytes are more sensitive to T cell receptor stimulation than mature T cells

21 January 2018

1 reference

A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity

21 January 2018

1 reference

A requirement for sustained ERK signaling during thymocyte positive selection in vivo

21 January 2018

1 reference

Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling

21 January 2018

1 reference

Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection

21 January 2018

1 reference

Themis, a T cell-specific protein important for late thymocyte development

21 January 2018

1 reference

CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision

21 January 2018

1 reference

The role of erk1 and erk2 in multiple stages of T cell development.

21 January 2018

1 reference

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

21 January 2018

1 reference

T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse

21 January 2018

1 reference

A two-step process for thymic regulatory T cell development.

21 January 2018

1 reference

Control of central and peripheral tolerance by Aire

21 January 2018

1 reference

Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation

21 January 2018

1 reference

MEK activity regulates negative selection of immature CD4+CD8+ thymocytes.

21 January 2018

1 reference

A discrete affinity-driven elevation of ZAP-70 kinase activity initiates negative selection

21 January 2018

1 reference

Kinase suppressor of Ras 1 is required for full ERK activation in thymocytes but not for thymocyte selection.

21 January 2018

1 reference

Homeostasis of naive and memory T cells

21 January 2018

1 reference

Naive T cell homeostasis: from awareness of space to a sense of place

21 January 2018

1 reference

Differential requirements for survival and proliferation of CD8 naïve or memory T cells

21 January 2018

1 reference

The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery

21 January 2018

1 reference

Low-affinity ligands for the TCR drive proliferation of mature CD8+ T cells in lymphopenic hosts

21 January 2018

1 reference

CD8 lineage commitment in the absence of CD8.

21 January 2018

1 reference

Involvement of avidity for major histocompatibility complex in homeostasis of naive and memory T cells

21 January 2018

1 reference

A role for TCR affinity in regulating naive T cell homeostasis.

21 January 2018

1 reference

A role for CD5 in TCR-mediated signal transduction and thymocyte selection

21 January 2018

1 reference

Sensory adaptation in naive peripheral CD4 T cells

21 January 2018

1 reference

CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity

21 January 2018

1 reference

Signaling thresholds govern heterogeneity in IL-7-receptor-mediated responses of naïve CD8(+) T cells

21 January 2018

1 reference

Competition for self-peptide-MHC complexes and cytokines between naive and memory CD8+ T cells expressing the same or different T cell receptors

21 January 2018

1 reference

'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.

21 January 2018

1 reference

Size estimate of the alpha beta TCR repertoire of naive mouse splenocytes

21 January 2018

1 reference

Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells

21 January 2018

1 reference

Quantitation of antigen-presenting cell MHC class II/peptide complexes necessary for T-cell stimulation

21 January 2018

1 reference

Direct observation of ligand recognition by T cells.

21 January 2018

1 reference

CD8 modulation of T-cell antigen receptor–ligand interactions on living cytotoxic T lymphocytes

21 January 2018

1 reference

Erratum: Costimulation and endogenous MHC ligands contribute to T cell recognition

21 January 2018

1 reference

Mechanistic basis of pre–T cell receptor–mediated autonomous signaling critical for thymocyte development

21 January 2018

1 reference

Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

21 January 2018

1 reference

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

21 January 2018

1 reference

Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

21 January 2018

1 reference

Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells

21 January 2018

1 reference

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

21 January 2018

1 reference

Duration and Strength of Extracellular Signal-Regulated Kinase Signals Are Altered During Positive Versus Negative Thymocyte Selection

21 January 2018

1 reference

Cooperativity between T cell receptor complexes revealed by conformational mutants of CD3epsilon

21 January 2018

1 reference

12 December 2020

Identification of a naturally occurring ligand for thymic positive selection

1 reference

12 December 2020

Separation of IL-4 production from Th cell proliferation by an altered T cell receptor ligand

1 reference

12 December 2020

Designing and maintaining the mature TCR repertoire: the continuum of self-peptide:self-MHC complex recognition

1 reference

12 December 2020

MHC Class II Molecules Are Not Required for Survival of Newly Generated CD4+ T Cells, but Affect Their Long-Term Life Span

1 reference

12 December 2020

Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture

1 reference

12 December 2020

Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response

1 reference

12 December 2020

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

1 reference

12 December 2020

Full Activation of the T Cell Receptor Requires Both Clustering and Conformational Changes at CD3

1 reference

12 December 2020

Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy

1 reference

12 December 2020

Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer

1 reference

12 December 2020

Phosphorylation of T cell receptor zeta is regulated by a lipid dependent folding transition

1 reference

12 December 2020

Low activation threshold as a mechanism for ligand-independent signaling in pre-T cells

1 reference

12 December 2020

Differential requirements for CD4 in TCR-ligand interactions

1 reference

12 December 2020

Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells

1 reference

12 December 2020

Cooperativity Between T Cell Receptor Complexes Revealed by Conformational Mutants of CD3

1 reference

7 January 2021