(Q38797329)

6 September 2017

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title

Genome scale metabolic modeling of cancer (English)

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6 September 2017

2

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6 September 2017

Avlant Nilsson

1

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publication date

4 November 2016

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6 September 2017

published in

Metabolic Engineering

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Prediction of microbial growth rate versus biomass yield by a metabolic network with kinetic parameters

6 September 2017

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Evaluation of substituted N,N'-diarylsulfonamides as activators of the tumor cell specific M2 isoform of pyruvate kinase

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Measurement of mass, density, and volume during the cell cycle of yeast

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Regulation of cancer cell metabolism

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

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Spatially-resolved metabolic cooperativity within dense bacterial colonies

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Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

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7 January 2021

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

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Biomass composition: the "elephant in the room" of metabolic modelling

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The metabolic demands of cancer cells are coupled to their size and protein synthesis rates

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Global reconstruction of the human metabolic network based on genomic and bibliomic data

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Reconstruction and validation of Saccharomyces cerevisiae iND750, a fully compartmentalized genome-scale metabolic model

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Identifying tightly regulated and variably expressed networks by Differential Rank Conservation (DIRAC).

7 January 2021

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Saccharomyces cerevisiae phenotypes can be predicted by using constraint-based analysis of a genome-scale reconstructed metabolic network

7 January 2021

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Quantitative flux analysis reveals folate-dependent NADPH production.

7 January 2021

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The biomass objective function

7 January 2021

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Predicting selective drug targets in cancer through metabolic networks.

7 January 2021

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Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

7 January 2021

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Chromosome 3p loss of heterozygosity is associated with a unique metabolic network in clear cell renal carcinoma

7 January 2021

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Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism

7 January 2021

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Glycosaminoglycan Profiling in Patients' Plasma and Urine Predicts the Occurrence of Metastatic Clear Cell Renal Cell Carcinoma

7 January 2021

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Cancer Metabolism: A Modeling Perspective

7 January 2021

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Identifying anti-growth factors for human cancer cell lines through genome-scale metabolic modeling.

7 January 2021

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p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production

7 January 2021

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Acetic acid formation in Escherichia coli fermentation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Hallmarks of Cancer: The Next Generation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Metabolic pathway alterations that support cell proliferation.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Glutamine and cancer: cell biology, physiology, and clinical opportunities

7 January 2021

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Amino Acids Rather than Glucose Account for the Majority of Cell Mass in Proliferating Mammalian Cells

7 January 2021

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Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation

7 January 2021

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Functional integration of a metabolic network model and expression data without arbitrary thresholding.

7 January 2021

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Predicting drug targets and biomarkers of cancer via genome-scale metabolic modeling

7 January 2021

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Computational reconstruction of tissue-specific metabolic models: application to human liver metabolism

7 January 2021

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Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery

7 January 2021

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Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer.

7 January 2021

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Integrating cellular metabolism into a multiscale whole-body model

7 January 2021

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The evolution of genome-scale models of cancer metabolism

7 January 2021

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Omic data from evolved E. coli are consistent with computed optimal growth from genome-scale models

7 January 2021

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Constraining the metabolic genotype-phenotype relationship using a phylogeny of in silico methods

7 January 2021

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6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling

7 January 2021

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The Edinburgh human metabolic network reconstruction and its functional analysis

7 January 2021

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Dynamic flux balance analysis of diauxic growth in Escherichia coli

7 January 2021

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Real-time detection of 13C NMR labeling kinetics in perfused EMT6 mouse mammary tumor cells and betaHC9 mouse insulinomas

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

New paradigms for metabolic modeling of human cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Metabolic cancer biology: structural-based analysis of cancer as a metabolic disease, new sights and opportunities for disease treatment

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Shifts in growth strategies reflect tradeoffs in cellular economics

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

A systems approach to predict oncometabolites via context-specific genome-scale metabolic networks

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Metabolic Trade-offs in Yeast are Caused by F1F0-ATP synthase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Flux distributions in anaerobic, glucose-limited continuous cultures of Saccharomyces cerevisiae.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

A feeling for the numbers in biology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

The human serum metabolome

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Modeling core metabolism in cancer cells: surveying the topology underlying the Warburg effect

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Modeling metabolism: a window toward a comprehensive interpretation of networks in cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Mechanistic modeling of aberrant energy metabolism in human disease

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Use of randomized sampling for analysis of metabolic networks

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Interdependence of cell growth and gene expression: origins and consequences.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Analysis of optimality in natural and perturbed metabolic networks

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Tumor metabolism: cancer cells give and take lactate

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Metabolic network modeling approaches for investigating the "hungry cancer".

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

A genome-scale computational study of the interplay between transcriptional regulation and metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Network-based prediction of human tissue-specific metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Predicting metabolic biomarkers of human inborn errors of metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Quantitation of cellular metabolic fluxes of methionine.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Oxidative phosphorylation in cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Growth of Saccharomyces cerevisiae is controlled by its limited respiratory capacity: Formulation and verification of a hypothesis.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Recon 2.2: from reconstruction to model of human metabolism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Estimating Tumor Growth Rates In Vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

A community-driven global reconstruction of human metabolism.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Energy expended by low birth weight infants in the deposition of protein and fat.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Kiwi: a tool for integration and visualization of network topology and gene-set analysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Understanding the Warburg effect: the metabolic requirements of cell proliferation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Molecular crowding defines a common origin for the Warburg effect in proliferating cells and the lactate threshold in muscle physiology

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Catabolic efficiency of aerobic glycolysis: the Warburg effect revisited

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Serine biosynthesis with one carbon catabolism and the glycine cleavage system represents a novel pathway for ATP generation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

A theoretical evaluation of growth yields of yeasts

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

The Myc oncoprotein as a therapeutic target for human cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Reconstruction of genome-scale metabolic models for 126 human tissues using mCADRE

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

High ratio of resting energy expenditure to body mass in childhood and adolescence: a mechanistic model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Metabolic reprogramming: a cancer hallmark even warburg did not anticipate

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Amino acid composition of the fetal pig

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Evidence That Does Not Support Pyruvate Kinase M2 (PKM2)-catalyzed Reaction as a Rate-limiting Step in Cancer Cell Glycolysis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

Modeling cancer metabolism on a genome scale

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YMBEN.2016.10.022

10.1016/J.YMBEN.2016.10.022

7 January 2021

Identifiers

DOI

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6 September 2017

1 reference