(Q38797421)

English

Iterative design of emetine-based prodrug targeting fibroblast activation protein (FAP) and dipeptidyl peptidase IV DPPIV using a tandem enzymatic activation strategy.

scientific article published on 2 February 2016

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scholarly article

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Europe PubMed Central

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6 March 2020

Iterative design of emetine-based prodrug targeting fibroblast activation protein (FAP) and dipeptidyl peptidase IV DPPIV using a tandem enzymatic activation strategy (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26835873%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

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author name string

Emmanuel S Akinboye

1

1 reference

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6 March 2020

W Nathaniel Brennen

2

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6 March 2020

D Marc Rosen

3

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6 March 2020

Oladapo Bakare

4

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6 March 2020

Samuel R Denmeade

5

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6 March 2020

publication date

2 February 2016

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6 March 2020

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6 March 2020

76

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6 March 2020

8

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6 March 2020

703-714

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6 March 2020

Structural basis for inhibition of protein synthesis by emetine and cycloheximide based on an analogy between ipecac alkaloids and glutarimide antibiotics

1 reference

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21 January 2018

Enzymic and nonenzymic translocation by yeast polysomes. Site of action of a number of inhibitors

1 reference

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21 January 2018

Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Design, synthesis, and evaluation of pH-dependent hydrolyzable emetine analogues as treatment for prostate cancer.

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Design, synthesis and cytotoxicity studies of dithiocarbamate ester derivatives of emetine in prostate cancer cell lines.

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly(2)-Pro(1)-cleaving specificity

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Rationale behind targeting fibroblast activation protein-expressing carcinoma-associated fibroblasts as a novel chemotherapeutic strategy

1 reference

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21 January 2018

Cell-surface glycoproteins of human sarcomas: differential expression in normal and malignant tissues and cultured cells

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

The dipeptidyl peptidase IV family in cancer and cell biology.

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Fibroblast activation protein, a dual specificity serine protease expressed in reactive human tumor stromal fibroblasts

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Fibroblast activation protein peptide substrates identified from human collagen I derived gelatin cleavage sites

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Targeting carcinoma-associated fibroblasts within the tumor stroma with a fibroblast activation protein-activated prodrug

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Pharmacokinetics and toxicology of a fibroblast activation protein (FAP)-activated prodrug in murine xenograft models of human cancer

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Targeting the cancer stroma with a fibroblast activation protein-activated promelittin protoxin

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Optimization of an albumin-binding prodrug of Doxorubicin that is cleaved by prostate-specific antigen

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Expression and localization of aminopeptidase A, aminopeptidase N, and dipeptidyl peptidase IV in benign and malignant human prostate tissue.

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Proline-dependent structural and biological properties of peptides and proteins

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

The purification and characterisation of novel dipeptidyl peptidase IV-like activity from bovine serum

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Novel water-soluble prodrugs of acyclovir cleavable by the dipeptidyl-peptidase IV (DPP IV/CD26) enzyme

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Low-calcium serum-free defined medium selects for growth of normal prostatic epithelial stem cells.

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Design and Discovery of a Novel Dipeptidyl-peptidase IV (CD26)-Based Prodrug Approach

1 reference

https://api.crossref.org/works/10.1002%2FPROS.23162

21 January 2018

Fibroblast activation protein: A cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/26835873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dipeptidylpeptidase IV activities are elevated in prostate cancers and adjacent benign hyperplastic glands

1 reference

https://pubmed.ncbi.nlm.nih.gov/26835873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo activity of a PSA-activated doxorubicin prodrug against PSA-producing human prostate cancer xenografts

1 reference

https://pubmed.ncbi.nlm.nih.gov/26835873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase I-II evaluation of emetine (NSC-33669) in the treatment of epidermoid bronchogenic carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/26835873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26835873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distribution of proline-specific aminopeptidases in human tissues and body fluids

1 reference

https://pubmed.ncbi.nlm.nih.gov/26835873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

THE TREATMENT OF AMOEBIC DYSENTERY WITH EMETINE AND BISMUTH IODIDE

1 reference

https://pubmed.ncbi.nlm.nih.gov/26835873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase II study of emetine (NSC-33669) in the treatment of solid tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/26835873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of advanced gastrointestinal cancer with ememtine (NSC-33669)

1 reference

https://pubmed.ncbi.nlm.nih.gov/26835873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A phase I study of emetine hydrochloride (NSC 33669) in solid tumors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26835873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Experience with emetine hydrochloride (NSC 33669) as an antitumor agent

1 reference

https://pubmed.ncbi.nlm.nih.gov/26835873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel connector linkage applicable in prodrug design

1 reference

https://pubmed.ncbi.nlm.nih.gov/26835873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation and heteromeric structure of the fibroblast activation protein in normal and transformed cells of mesenchymal and neuroectodermal origin

1 reference

https://pubmed.ncbi.nlm.nih.gov/26835873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular modeling study of tubulosine and other related ipecac alkaloids

1 reference

https://pubmed.ncbi.nlm.nih.gov/26835873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cathepsin B-sensitive dipeptide prodrugs. 1. A model study of structural requirements for efficient release of doxorubicin

1 reference

https://pubmed.ncbi.nlm.nih.gov/26835873

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/PROS.23162

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26835873%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26835873%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26835873%20AND%20SRC:MED&resulttype=core&format=json

6 March 2020

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