(Q38819909)

6 September 2017

title

Metastasis as an evolutionary process (English)

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6 September 2017

Charles Swanton

2

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author name string

Samra Turajlic

series ordinal

1

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6 September 2017

language of work or name

English

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publication date

1 April 2016

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6 September 2017

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6 September 2017

volume

352

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6 September 2017

issue

6282

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6 September 2017

page(s)

169-175

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Tumor metastasis: molecular insights and evolving paradigms

6 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Unravelling the complexity of metastasis - molecular understanding and targeted therapies

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Implications of intratumour heterogeneity for treatment stratification

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Mutation selection and the natural history of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Parallel progression of primary tumours and metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Genomic instability--an evolving hallmark of cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Hotspot mutation panel testing reveals clonal evolution in a study of 265 paired primary and metastatic tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Comparative analysis of primary tumour and matched metastases in colorectal cancer patients: evaluation of concordance between genomic and transcriptional profiles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

The landscape of somatic copy-number alteration across human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Spatial and temporal diversity in genomic instability processes defines lung cancer evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Tracking the genomic evolution of esophageal adenocarcinoma through neoadjuvant chemotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Using tumour phylogenetics to identify the roots of metastasis in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Phylogenetic analyses of melanoma reveal complex patterns of metastatic dissemination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Whole genome sequencing of matched primary and metastatic acral melanomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Subclonal Genomic Architectures of Primary and Metastatic Colorectal Cancer Based on Intratumoral Genetic Heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Genome remodelling in a basal-like breast cancer metastasis and xenograft

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Subclonal diversification of primary breast cancer revealed by multiregion sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Tumour evolution inferred by single-cell sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Mutational evolution in a lobular breast tumour profiled at single nucleotide resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

The patterns and dynamics of genomic instability in metastatic pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Distinctive Spatiotemporal Stability of Somatic Mutations in Metastasized Microsatellite-stable Colorectal Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

The Molecular Taxonomy of Primary Prostate Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Integrative clinical genomics of advanced prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Copy number alteration burden predicts prostate cancer relapse

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Tracking the origin of metastatic prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Intratumor heterogeneity: evolution through space and time

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

The evolutionary history of lethal metastatic prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Early and multiple origins of metastatic lineages within primary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Cancer chromosomal instability: therapeutic and diagnostic challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Evolution of metastasis revealed by mutational landscapes of chemically induced skin cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

BAF180 promotes cohesion and prevents genome instability and aneuploidy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Paired exome analysis of Barrett's esophagus and adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

The Genetic Evolution of Melanoma from Precursor Lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Tracking the clonal origin of lethal prostate cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Whole-genome sequencing reveals complex mechanisms of intrinsic resistance to BRAF inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Brain metastases: the HER2 paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Pan-cancer patterns of somatic copy number alteration

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Surviving at a distance: organ specific metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Phosphatidylinositol 3-kinase pathway activation in breast cancer brain metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Targeting hyperactivation of the AKT survival pathway to overcome therapy resistance of melanoma brain metastases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Pancreatic Cancer Metastases Harbor Evidence of Polyclonality

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Circulating tumor cell clusters are oligoclonal precursors of breast cancer metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Collective invasion in breast cancer requires a conserved basal epithelial program

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

A functional role for tumor cell heterogeneity in a mouse model of small cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Links between mutant p53 and genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Cancer: evolution within a lifetime

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Metastatic pattern of malignant melanoma. A study of 216 autopsy cases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Exome Sequencing of Cell-Free DNA from Metastatic Cancer Patients Identifies Clinically Actionable Mutations Distinct from Primary Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

Is cancer a disease of self-seeding?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAF2784

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.AAF2784

1 reference

6 September 2017

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