(Q38829781)

English

Chronic Hypoxia-Induced Autophagy Aggravates the Neuropathology of Alzheimer's Disease through AMPK-mTOR Signaling in the APPSwe/PS1dE9 Mouse Model

scientific article published on 22 September 2015

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scholarly article

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Europe PubMed Central

PubMed publication ID

6 September 2017

Chronic Hypoxia-Induced Autophagy Aggravates the Neuropathology of Alzheimer's Disease through AMPK-mTOR Signaling in the APPSwe/PS1dE9 Mouse Model (English)

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

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Alzheimer's disease

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1 reference

based on heuristic

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author name string

Hui Liu

1

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

Hongyan Qiu

2

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

Qian Xiao

3

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

Weidong Le

4

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

publication date

22 September 2015

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Europe PubMed Central

PubMed publication ID

6 September 2017

Journal of Alzheimer's Disease

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Europe PubMed Central

PubMed publication ID

6 September 2017

48

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Europe PubMed Central

PubMed publication ID

6 September 2017

4

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Europe PubMed Central

PubMed publication ID

6 September 2017

1019-1032

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Europe PubMed Central

PubMed publication ID

6 September 2017

A century of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Neurodegenerative tauopathies

1 reference

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21 January 2018

A century-old debate on protein aggregation and neurodegeneration enters the clinic

1 reference

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21 January 2018

Amyloid-β and tau--a toxic pas de deux in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Autophagy fights disease through cellular self-digestion

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

The role of autophagy in neurodegenerative disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Beta-amyloid is a substrate of autophagy in sporadic inclusion body myositis.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

A(beta) generation in autophagic vacuoles

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Autophagic vacuoles are enriched in amyloid precursor protein-secretase activities: implications for beta-amyloid peptide over-production and localization in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Autophagy: many paths to the same end.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Regulation mechanisms and signaling pathways of autophagy

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Regulation of mammalian autophagy in physiology and pathophysiology.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Aβ-induced formation of autophagosomes is mediated by RAGE-CaMKKβ-AMPK signaling

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

A possible linkage between AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling pathway

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

AMPK: a key sensor of fuel and energy status in skeletal muscle

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Pathological role of hypoxia in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Prenatal hypoxia may aggravate the cognitive impairment and Alzheimer's disease neuropathology in APPSwe/PS1A246E transgenic mice

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Dementia after stroke: the Framingham Study.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Epidemiological studies of the effect of stroke on incident dementia: a systematic review

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Increasing rates of dementia at time of declining mortality from stroke.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Network hyperexcitability in hippocampal slices from Mecp2 mutant mice revealed by voltage-sensitive dye imaging.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Physiological and pathological responses to hypoxia

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

The regulation of AMP-activated protein kinase by phosphorylation

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Role of AMP-activated protein kinase in mechanism of metformin action

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Autophagy and the integrated stress response

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Autophagy: process and function

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Autophagy in neurodegenerative diseases: From pathogenic dysfunction to therapeutic modulation

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Autophagy in neurodegenerative diseases: from mechanism to therapeutic approach

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Control of autophagy as a therapy for neurodegenerative disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Autophagy failure in Alzheimer's disease--locating the primary defect

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Age-related autophagy alterations in the brain of senescence accelerated mouse prone 8 (SAMP8) mice.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Autophagy, amyloidogenesis and Alzheimer disease

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer's mice hippocampus.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

AMP-activated Protein Kinase and the Regulation of Autophagic Proteolysis

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Regulation of autophagy through multiple independent hypoxic signaling pathways.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Hypoxia induces autophagic cell death in apoptosis-competent cells through a mechanism involving BNIP3.

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Hypoxia signalling through mTOR and the unfolded protein response in cancer

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150303

21 January 2018

Identifiers

10.3233/JAD-150303

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 September 2017

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