(Q38834682)

6 September 2017

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title

Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation (English)

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6 September 2017

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2

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6 September 2017

Xabier Urra

3

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author name string

Ángel Chamorro

series ordinal

1

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6 September 2017

Anna M Planas

series ordinal

4

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6 September 2017

publication date

11 May 2016

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6 September 2017

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6 September 2017

volume

15

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6 September 2017

issue

8

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6 September 2017

page(s)

869-881

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Global and regional burden of stroke during 1990-2010: findings from the Global Burden of Disease Study 2010

6 September 2017

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7 January 2021

Exciting, radical, suicidal: how brain cells die after stroke

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7 January 2021

1,026 experimental treatments in acute stroke

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7 January 2021

Gaps Between Aims and Achievements in Therapeutic Modification of Neuronal Damage ("Neuroprotection").

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7 January 2021

Glutamate and the pathophysiology of hypoxic--ischemic brain damage

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7 January 2021

Tissue plasminogen activator for acute ischemic stroke

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7 January 2021

Tissue plasminogen activator reduces neurological damage after cerebral embolism.

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7 January 2021

The science of stroke: mechanisms in search of treatments

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7 January 2021

Analysis of early phase and subsequent phase III stroke studies of neuroprotectants: outcomes and predictors for success

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7 January 2021

Neuroprotection for ischemic stroke: past, present and future

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7 January 2021

Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions

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7 January 2021

Translating promising preclinical neuroprotective therapies to human stroke trials

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7 January 2021

Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials

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7 January 2021

Prediction of Early Arterial Recanalization and Tissue Fate in the Selection of Patients With the Greatest Potential to Benefit From Intravenous Tissue-Type Plasminogen Activator

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7 January 2021

Meta-analysis of randomized intra-arterial thrombolytic trials for the treatment of acute stroke due to middle cerebral artery occlusion

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7 January 2021

Thrombolysis (different doses, routes of administration and agents) for acute ischaemic stroke

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7 January 2021

Intra-arterial thrombolysis vs. standard treatment or intravenous thrombolysis in adults with acute ischemic stroke: a systematic review and meta-analysis

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7 January 2021

2015 American Heart Association/American Stroke Association Focused Update of the 2013 Guidelines for the Early Management of Patients With Acute Ischemic Stroke Regarding Endovascular Treatment: A Guideline for Healthcare Professionals From the Ame

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7 January 2021

Thrombectomy within 8 hours after symptom onset in ischemic stroke

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7 January 2021

Stent-retriever thrombectomy after intravenous t-PA vs. t-PA alone in stroke

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7 January 2021

Randomized assessment of rapid endovascular treatment of ischemic stroke

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7 January 2021

Endovascular therapy for ischemic stroke with perfusion-imaging selection

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7 January 2021

A randomized trial of intraarterial treatment for acute ischemic stroke

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7 January 2021

Endovascular Thrombectomy for Anterior Circulation Stroke: Systematic Review and Meta-Analysis.

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7 January 2021

MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

A trial of imaging selection and endovascular treatment for ischemic stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Role of imaging in current acute ischemic stroke workflow for endovascular therapy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Free radicals in cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Superoxide dismutase 1 overexpression reduces MCP-1 and MIP-1 alpha expression after transient focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Neuronal oxidative stress in acute ischemic stroke: sources and contribution to cell injury

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Cerebral microvessel responses to focal ischemia

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https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Reperfusion versus recanalization: the winner is….

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Polymorphonuclear leukocytes occlude capillaries following middle cerebral artery occlusion and reperfusion in baboons

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Targeting neutrophils in ischemic stroke: translational insights from experimental studies.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

High-dose albumin treatment for acute ischaemic stroke (ALIAS) Part 2: a randomised, double-blind, phase 3, placebo-controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Capillary pericytes regulate cerebral blood flow in health and disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Nox4 is a major source of superoxide production in human brain pericytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Role of endothelial nitric oxide generation and peroxynitrite formation in reperfusion injury after focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Excitotoxicity and stroke: identifying novel targets for neuroprotection.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Prehospital use of magnesium sulfate as neuroprotection in acute stroke

1 reference

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7 January 2021

Safety and efficacy of NA-1 in patients with iatrogenic stroke after endovascular aneurysm repair (ENACT): a phase 2, randomised, double-blind, placebo-controlled trial.

1 reference

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7 January 2021

Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Treatment of stroke with a PSD-95 inhibitor in the gyrencephalic primate brain

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

A novel mechanism of neuroprotection: Blood glutamate grabber

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Amelioration of ischemic brain damage by peritoneal dialysis.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Ginsenoside-Rd improves outcome of acute ischaemic stroke - a randomized, double-blind, placebo-controlled, multicenter trial.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Peroxynitrite formation in focal cerebral ischemia-reperfusion in rats occurs predominantly in the peri-infarct region

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

In vivo detection of superoxide anion production by the brain using a cytochrome c electrode

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Nitric oxide and peroxynitrite in health and disease

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Oxidative damage and tyrosine nitration from peroxynitrite

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

NXY-059 for acute ischemic stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

NXY-059 for the treatment of acute ischemic stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Towards the physiological function of uric acid

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Uric acid protects neurons against excitotoxic and metabolic insults in cell culture, and against focal ischemic brain injury in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Reaction of uric acid with peroxynitrite and implications for the mechanism of neuroprotection by uric acid

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Uric acid reduces brain damage and improves the benefits of rt-PA in a rat model of thromboembolic stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Middle cerebral artery remodeling following transient brain ischemia is linked to early postischemic hyperemia: a target of uric acid treatment

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Safety and efficacy of uric acid in patients with acute stroke (URICO-ICTUS): a randomised, double-blind phase 2b/3 trial

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Uric Acid Therapy Improves Clinical Outcome in Women With Acute Ischemic Stroke.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Uric acid improves glucose-driven oxidative stress in human ischemic stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Comparison of the radical trapping ability of PBN, S-PPBN and NXY-059.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

A critical assessment of edaravone acute ischemic stroke efficacy trials: is edaravone an effective neuroprotective therapy?

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Edaravone for acute ischaemic stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Chronic protection against ischemia and reperfusion-induced endothelial dysfunction during therapy with different organic nitrates

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

A systematic review of nitric oxide donors and L-arginine in experimental stroke; effects on infarct size and cerebral blood flow.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

The immunology of acute stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Temporal and spatial dynamics of cerebral immune cell accumulation in stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Sterile inflammation: sensing and reacting to damage

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Neutrophil infiltration increases matrix metalloproteinase-9 in the ischemic brain after occlusion/reperfusion of the middle cerebral artery in rats

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Neutrophil recruitment and function in health and inflammation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Neurotransmitter receptors on microglia.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Ischemia and reperfusion--from mechanism to translation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Harms and benefits of lymphocyte subpopulations in patients with acute stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Systematic review and meta-analysis of the efficacy of sphingosine-1-phosphate (S1P) receptor agonist FTY720 (fingolimod) in animal models of stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Fingolimod provides long-term protection in rodent models of cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Fingolimod protects cultured cortical neurons against excitotoxic death

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

FTY720 attenuates excitotoxicity and neuroinflammation.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Molecular targets of FTY720 (fingolimod).

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Impact of an immune modulator fingolimod on acute ischemic stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Combination of the Immune Modulator Fingolimod With Alteplase in Acute Ischemic Stroke: A Pilot Trial

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Blocking of α4 integrin does not protect from acute ischemic stroke in mice.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Results of a preclinical randomized controlled multicenter trial (pRCT): Anti-CD49d treatment for acute brain ischemia.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Interleukin-1 and neuronal injury

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Treating inflammation by blocking interleukin-1 in humans

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Delayed administration of interleukin-1 receptor antagonist protects against transient cerebral ischaemia in the rat.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Stroke, IL-1ra, IL1RN, infection and outcome

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Extension of the thrombolytic time window with minocycline in experimental stroke.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Minocycline to improve neurologic outcome in stroke (MINOS): a dose-finding study

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Intravenous minocycline in acute stroke: a randomized, controlled pilot study and meta-analysis

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Magnesium neuroprotection is limited in humans with acute brain injury

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Found in translation: preclinical stroke research predicts human pathophysiology, clinical phenotypes, and therapeutic outcomes.

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Bringing rigour to translational medicine

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Publication bias in reports of animal stroke studies leads to major overstatement of efficacy

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

A call for transparent reporting to optimize the predictive value of preclinical research

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

The two pathophysiologies of focal brain ischemia: implications for translational stroke research

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Effect of the use of ambulance-based thrombolysis on time to thrombolysis in acute ischemic stroke: a randomized clinical trial

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Nonhuman primate models of stroke for translational neuroprotection research

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

1 reference

7 January 2021

A combined pre-clinical meta-analysis and randomized confirmatory trial approach to improve data validity for therapeutic target validation

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

Neuroprotection and thrombolysis: combination therapy in acute ischaemic stroke

1 reference

https://api.crossref.org/works/10.1016%2FS1474-4422%2816%2900114-9

7 January 2021

10.1016/S1474-4422(16)00114-9

Identifiers

DOI

1 reference

6 September 2017

1 reference