(Q38838317)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26335661%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

title

Prediction and validation of enzyme and transporter off-targets for metformin (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26335661%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26335661%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

Matthew Merski

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26335661%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

Michael J Keiser

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26335661%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

author name string

Lawrence Lin

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26335661%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

Aakash Gupta

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26335661%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

Youcai Zhang

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26335661%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

Huan-Chieh Chien

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26335661%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

Brian K Shoichet

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26335661%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

Kathleen M Giacomini

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26335661%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

publication date

3 September 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26335661%20AND%20SRC:MED&resulttype=core&format=json

Journal of Pharmacokinetics and Pharmacodynamics

23 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26335661%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

volume

42

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26335661%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26335661%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

page(s)

463-475

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26335661%20AND%20SRC:MED&resulttype=core&format=json

https://scigraph.springernature.com/pub.10.1007/s10928-015-9436-y

23 February 2020

exact match

0 references

cites work

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1 reference

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Targeted disruption of organic cation transporter 3 attenuates the pharmacologic response to metformin

9 September 2017

1 reference

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Proteomics. Tissue-based map of the human proteome

9 September 2017

3 references

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9 September 2017

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2 December 2018

12 December 2020

Four cation-selective transporters contribute to apical uptake and accumulation of metformin in Caco-2 cell monolayers

1 reference

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Association of Organic Cation Transporter 1 With Intolerance to Metformin in Type 2 Diabetes: A GoDARTS Study.

9 September 2017

1 reference

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Histamine H₄ receptors in the gastrointestinal tract.

9 September 2017

1 reference

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Taste of a pill: organic cation transporter-3 (OCT3) mediates metformin accumulation and secretion in salivary glands

9 September 2017

1 reference

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OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin.

9 September 2017

1 reference

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An atlas of genetic influences on human blood metabolites

9 September 2017

1 reference

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Common drugs inhibit human organic cation transporter 1 (OCT1)-mediated neurotransmitter uptake

9 September 2017

1 reference

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Histamine and gut mucosal immune regulation

9 September 2017

1 reference

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Serotonin signalling in the gut--functions, dysfunctions and therapeutic targets

9 September 2017

1 reference

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An introduction to sequence similarity ("homology") searching

9 September 2017

1 reference

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Organic cation transporter 1 (OCT1/mOct1) is localized in the apical membrane of Caco-2 cell monolayers and enterocytes.

9 September 2017

1 reference

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Revisiting the mechanisms of metformin action in the liver

9 September 2017

1 reference

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Serum diamine oxidase activity as a diagnostic test for histamine intolerance.

9 September 2017

1 reference

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Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4)

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Discovery of potent, selective multidrug and toxin extrusion transporter 1 (MATE1, SLC47A1) inhibitors through prescription drug profiling and computational modeling

9 September 2017

1 reference

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Large-scale prediction and testing of drug activity on side-effect targets

9 September 2017

1 reference

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Identifying mechanism-of-action targets for drugs and probes.

9 September 2017

1 reference

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Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study

9 September 2017

1 reference

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Cellular and molecular mechanisms of metformin: an overview

9 September 2017

1 reference

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Interactions of tyrosine kinase inhibitors with organic cation transporters and multidrug and toxic compound extrusion proteins

9 September 2017

1 reference

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Metformin and digestive disorders.

9 September 2017

1 reference

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Towards a knowledge-based Human Protein Atlas

9 September 2017

1 reference

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Role of organic cation transporter 3 (SLC22A3) and its missense variants in the pharmacologic action of metformin

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Selective transport of monoamine neurotransmitters by human plasma membrane monoamine transporter and organic cation transporter 3

9 September 2017

1 reference

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Membrane transporters in drug development

9 September 2017

1 reference

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Predicting new molecular targets for known drugs

9 September 2017

1 reference

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Structure and inhibition of human diamine oxidase

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver

9 September 2017

1 reference

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Quantifying the relationships among drug classes

9 September 2017

1 reference

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Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters

9 September 2017

1 reference

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Histamine and histamine intolerance

9 September 2017

1 reference

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Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Polyspecific organic cation transporters: structure, function, physiological roles, and biopharmaceutical implications

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Relating protein pharmacology by ligand chemistry

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

The serotonin signaling system: from basic understanding to drug development for functional GI disorders

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Drug specificity and intestinal membrane localization of human organic cation transporters (OCT).

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Review article: serotonin receptors and transporters -- roles in normal and abnormal gastrointestinal motility

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Pharmacological and physiological functions of the polyspecific organic cation transporters: OCT1, 2, and 3 (SLC22A1-3).

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Reduced hepatic uptake and intestinal excretion of organic cations in mice with a targeted disruption of the organic cation transporter 1 (Oct1 [Slc22a1]) gene

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Histamine-free diet: treatment of choice for histamine-induced food intolerance and supporting treatment for chronic headaches

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Review article: roles played by 5-hydroxytryptamine in the physiology of the bowel

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Propoxyphene and norpropoxyphene plasma concentrations in the anephric patient

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Functional analysis of human organic cation transporter OCT3 (SLC22A3) polymorphisms.

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Inhibition of diamine oxidase by antihistaminic agents and related drugs

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Studies on intestinal absorption of sulpiride (2): transepithelial transport of sulpiride across the human intestinal cell line Caco-2.

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Comparative tolerability profiles of oral antidiabetic agents

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

An update on histamine H3 receptors and gastrointestinal functions

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Involvement of organic cation transporter 1 in hepatic and intestinal distribution of metformin

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Metabolism of agmatine (clonidine-displacing substance) by diamine oxidase and the possible implications for studies of imidazoline receptors.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Cefoxitin and Cephamycins: Microbiological Studies

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Effects of metformin on intestinal 5-hydroxytryptamine (5-HT) release and on 5-HT3 receptors

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Distribution and properties of human intestinal diamine oxidase and its relevance for the histamine catabolism

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Kinetics of the diamine oxidase reaction

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Kinetics of drug action in disease states. VII. Effect of experimental renal dysfunction on the pharmacodynamics of ethanol in rats.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Kinetics of drug action in disease states. VI. Effect of experimental diabetes on phenobarbital concentrations in rats at onset of loss of righting reflex.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Inhibition of diamine oxidase from porcine kidney by pentamidine and other aminoguanidine compounds

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Mechanisms of vomiting induced by serotonin-3 receptor agonists in the cat: effect of vagotomy, splanchnicectomy or area postrema lesion

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Effects of histamine H1-, H2- and H3-receptor selective drugs on the mechanical activity of guinea-pig small and large intestine

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Effect of metformin on glucose metabolism in the splanchnic bed

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Mechanisms underlying saturable intestinal absorption of metformin

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Effects of metformin on bile salt transport by monolayers of human intestinal Caco-2 cells

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Adverse events and treatment discontinuations in clinical trials of fluoxetine in major depressive disorder: an updated meta-analysis.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

The effect of metformin treatment on gastric acid secretion and gastrointestinal hormone levels in normal subjects.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4656030

Hypoxic survival differs between two mole rat species (Spalax ehrenbergi) of humid and arid habitats

22 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1007%2FS10928-015-9436-Y

Guanabenz as inhibitor of copper-containing amine oxidases

21 January 2018

1 reference

12 December 2020

Diarrhea and Metformin in a Diabetic Clinic

1 reference

12 December 2020

Accumulation of metformin by tissues of the normal and diabetic mouse

1 reference

12 December 2020

Propoxyphene and norpropoxyphene plasma concentrations after oral propoxyphene in cirrhotic patients with and without surgically constructed portacaval shunt

1 reference

12 December 2020

Buffers of constant ionic strength for studying pH-dependent processes

1 reference

12 December 2020

New tools for studying old questions: antibodies for human diamine oxidase

1 reference

12 December 2020

Basophil expression of diamine oxidase: a novel biomarker of allergen immunotherapy response

1 reference

12 December 2020

Purification and characterization of diamine oxidase from porcine kidney and intestine

1 reference

12 December 2020

Probing the "active site" of diamine oxidase: structure-activity relations for histamine potentiation by O-alkylhydroxylamines on colonic epithelium

1 reference

12 December 2020

RELATIONSHIP BETWEEN RATE OF ELIMINATION OF TUBOCURARINE AND RATE OF DECLINE OF ITS PHARMACOLOGICAL ACTIVITY

1 reference

12 December 2020

Association of single nucleotide polymorphisms in the diamine oxidase gene with diamine oxidase serum activities

1 reference

12 December 2020

10.1007/S10928-015-9436-Y

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26335661%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

23 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26335661%20AND%20SRC:MED&resulttype=core&format=json

23 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26335661%20AND%20SRC:MED&resulttype=core&format=json