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Cellular and molecular mechanisms of metformin: an overview
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PubMed
title
Cellular and molecular mechanisms of metformin: an overview
(English)
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main subject
metformin
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inferred from title
author
Benoit Viollet
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1
object named as
Benoit Viollet
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Crossref
Bruno Guigas
object named as
Bruno Guigas
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2
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Marc Foretz
object named as
Marc Foretz
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5
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author name string
Nieves Sanz Garcia
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3
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stated in
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Jocelyne Leclerc
series ordinal
4
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stated in
Crossref
Fabrizio Andreelli
series ordinal
6
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stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
March 2012
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stated in
PubMed
published in
Clinical Science
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stated in
PubMed
volume
122
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stated in
PubMed
issue
6
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stated in
PubMed
page(s)
253-70
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stated in
PubMed
cites work
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Clinical Pharmacokinetics of Metformin
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Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?
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Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action
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21 March 2017
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility
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21 March 2017
Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes
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21 March 2017
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Metformin Inhibits Hepatic Gluconeogenesis Through AMP-Activated Protein Kinase-Dependent Regulation of the Orphan Nuclear Receptor SHP
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Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial
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21 March 2017
Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin
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21 March 2017
Mechanism by which metformin reduces glucose production in type 2 diabetes
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21 March 2017
Diabetes and cancer: a consensus report.
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21 March 2017
Metformin induces unique biological and molecular responses in triple negative breast cancer cells
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21 March 2017
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
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21 March 2017
Metformin-induced stimulation of adenosine 5' monophosphate-activated protein kinase (PRKA) impairs progesterone secretion in rat granulosa cells
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21 March 2017
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
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21 March 2017
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
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21 March 2017
Mechanism for fatty acid "sparing" effect on glucose-induced transcription: regulation of carbohydrate-responsive element-binding protein by AMP-activated protein kinase
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21 March 2017
Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1.
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7 April 2017
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group
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7 April 2017
AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
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7 April 2017
Metformin and reduced risk of cancer in diabetic patients
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7 April 2017
Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
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7 April 2017
Metformin activates AMP-activated protein kinase in primary human hepatocytes by decreasing cellular energy status
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Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation
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28 September 2017
Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice
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28 September 2017
Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1.
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28 September 2017
Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity.
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28 September 2017
Wrongfully accused: metformin use in heart failure
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28 September 2017
AMP-activated protein kinase inhibits NF-κB signaling and inflammation: impact on healthspan and lifespan
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28 September 2017
Metformin induces both caspase-dependent and poly(ADP-ribose) polymerase-dependent cell death in breast cancer cells
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28 September 2017
AMP-activated protein kinase activation during cardioplegia-induced hypoxia/reoxygenation injury attenuates cardiomyocytic apoptosis via reduction of endoplasmic reticulum stress
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28 September 2017
Crosstalk between components of circadian and metabolic cycles in mammals
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28 September 2017
Tubular injury in a rat model of type 2 diabetes is prevented by metformin: a possible role of HIF-1α expression and oxygen metabolism
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28 September 2017
Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis
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28 September 2017
Effect of metformin on cardiovascular events and mortality: a meta-analysis of randomized clinical trials
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28 September 2017
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
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28 September 2017
Metformin use and mortality among patients with diabetes and atherothrombosis
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28 September 2017
Metformin against TGFβ-induced epithelial-to-mesenchymal transition (EMT): from cancer stem cells to aging-associated fibrosis.
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28 September 2017
Metformin regulates the incretin receptor axis via a pathway dependent on peroxisome proliferator-activated receptor-α in mice
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28 September 2017
Pharmacogenetics of Anti-Diabetes Drugs
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28 September 2017
Metformin prevents tobacco carcinogen--induced lung tumorigenesis
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28 September 2017
AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner.
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28 September 2017
Metformin: taking away the candy for cancer?
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28 September 2017
Review: metformin: potential benefits and use in chronic kidney disease
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28 September 2017
Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats
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28 September 2017
Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
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An energetic tale of AMPK-independent effects of metformin.
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28 September 2017
Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation
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28 September 2017
Metformin, independent of AMPK, inhibits mTORC1 in a rag GTPase-dependent manner
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28 September 2017
Treatment of type 2 diabetes and outcomes in patients with heart failure: a nested case-control study from the U.K. General Practice Research Database
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28 September 2017
Long-term metformin use is associated with decreased risk of breast cancer.
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28 September 2017
Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells
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The risk of overall mortality in patients with type 2 diabetes receiving glipizide, glyburide, or glimepiride monotherapy: a retrospective analysis
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28 September 2017
Novel assay of metformin levels in patients with type 2 diabetes and varying levels of renal function: clinical recommendations
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28 September 2017
Metformin induces suppression of NAD(P)H oxidase activity in podocytes.
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28 September 2017
Energetic myocardial metabolism and oxidative stress: let's make them our friends in the fight against heart failure
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28 September 2017
Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16
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28 September 2017
Metformin selectively targets cancer stem cells, and acts together with chemotherapy to block tumor growth and prolong remission
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28 September 2017
Metformin disrupts crosstalk between G protein-coupled receptor and insulin receptor signaling systems and inhibits pancreatic cancer growth
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28 September 2017
Metformin use and prostate cancer in Caucasian men: results from a population-based case-control study
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28 September 2017
The influence of glucose-lowering therapies on cancer risk in type 2 diabetes
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28 September 2017
Metformin: safety in cardiac patients
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28 September 2017
New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes
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28 September 2017
Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein
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28 September 2017
Antidiabetic therapies affect risk of pancreatic cancer
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28 September 2017
Reduced-function SLC22A1 polymorphisms encoding organic cation transporter 1 and glycemic response to metformin: a GoDARTS study
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28 September 2017
Nitric oxide, NAD(P)H oxidase, and atherosclerosis
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28 September 2017
AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives.
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28 September 2017
The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells
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28 September 2017
Activation of AMP-activated protein kinase by metformin improves left ventricular function and survival in heart failure
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28 September 2017
Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review
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28 September 2017
Cell cycle arrest in Metformin treated breast cancer cells involves activation of AMPK, downregulation of cyclin D1, and requires p27Kip1 or p21Cip1.
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28 September 2017
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28 September 2017
Metformin versus insulin for the treatment of gestational diabetes
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28 September 2017
Hyperglycemia and adverse pregnancy outcomes
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28 September 2017
Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
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28 September 2017
The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level.
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28 September 2017
AMP-activated protein kinase activation as a strategy for protecting vascular endothelial function
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28 September 2017
Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells
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28 September 2017
Ovulatory response to treatment of polycystic ovary syndrome is associated with a polymorphism in the STK11 gene
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28 September 2017
Functional involvement of organic cation transporter1 (OCT1/Oct1) in the hepatic uptake of organic cations in humans and rats
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28 September 2017
Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth
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28 September 2017
Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
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28 September 2017
Dual antiglioma action of metformin: cell cycle arrest and mitochondria-dependent apoptosis.
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28 September 2017
Methyl succinate antagonises biguanide-induced AMPK-activation and death of pancreatic beta-cells through restoration of mitochondrial electron transfer.
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28 September 2017
Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
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28 September 2017
Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome
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28 September 2017
Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review
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28 September 2017
Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice
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28 September 2017
Metformin prevents high-glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process
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28 September 2017
Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver
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28 September 2017
AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells
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28 September 2017
AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms
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28 September 2017
Metformin inhibits mitochondrial permeability transition and cell death: a pharmacological in vitro study
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28 September 2017
Increased Incidence of Coronary Atherosclerosis in Type 2 Diabetes Mellitus: Mechanisms and Management
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28 September 2017
Metformin reverses fatty liver disease in obese, leptin-deficient mice
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28 September 2017
Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.
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28 September 2017
Modifications of citric acid cycle activity and gluconeogenesis in streptozotocin-induced diabetes and effects of metformin
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28 September 2017
The effect of metformin on the myocardial tolerance to ischemia-reperfusion injury in the rat model of diabetes mellitus type II.
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31 May 2018
Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2.
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31 May 2018
Action of metformin on erythrocyte membrane fluidity in vitro and in vivo
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31 May 2018
Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus.
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31 May 2018
AMPK is a direct adenylate charge-regulated protein kinase.
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28 November 2018
Metformin improves cardiac function in a nondiabetic rat model of post-MI heart failure.
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28 November 2018
Effect of metformin therapy on cardiac function and survival in a volume-overload model of heart failure in rats.
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28 November 2018
Insulin and metformin may prevent renal injury in young type 2 diabetic Goto-Kakizaki rats
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28 November 2018
Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo.
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28 November 2018
Metformin attenuates ventricular hypertrophy by activating the AMP-activated protein kinase-endothelial nitric oxide synthase pathway in rats.
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28 November 2018
The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation
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28 November 2018
Metformin suppresses azoxymethane-induced colorectal aberrant crypt foci by activating AMP-activated protein kinase
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28 November 2018
Glucose-lowering agents and cancer mortality rates in type 2 diabetes: assessing effects of time-varying exposure.
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28 November 2018
Metformin prevents experimental gentamicin-induced nephropathy by a mitochondria-dependent pathway
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28 November 2018
Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5.
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28 November 2018
Metformin inhibits inflammatory angiogenesis in a murine sponge model
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28 November 2018
Pregnancy outcomes in women with gestational diabetes treated with metformin or insulin: a case-control study
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28 November 2018
The effects of genetic polymorphisms in the organic cation transporters OCT1, OCT2, and OCT3 on the renal clearance of metformin.
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28 November 2018
Newer agents for blood glucose control in type 2 diabetes: summary of NICE guidance.
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28 November 2018
Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase.
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28 November 2018
Metformin in chemically-induced mammary carcinogenesis in rats
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28 November 2018
Comparative therapeutic effects of metformin and vitamin E in a model of non-alcoholic steatohepatitis in the young rat.
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28 November 2018
Insulin-lowering effects of metformin in women with early breast cancer
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28 November 2018
Metformin suppresses intestinal polyp growth in ApcMin/+ mice
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28 November 2018
OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine
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28 November 2018
Metformin attenuates the stimulatory effect of a high-energy diet on in vivo LLC1 carcinoma growth
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28 November 2018
The effect of metformin treatment on VEGF and PAI-1 levels in obese type 2 diabetic patients.
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28 November 2018
Hepatic glucose sensing via the CREB coactivator CRTC2.
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28 November 2018
Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons.
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28 November 2018
Activation of 5'-AMP-activated kinase with diabetes drug metformin induces casein kinase Iepsilon (CKIepsilon)-dependent degradation of clock protein mPer2.
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28 November 2018
The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin.
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28 November 2018
[Effect of fenofibrate and metformin on lipotoxicity in OLETF rat kidney].
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28 November 2018
Thiazolidinediones inhibit insulin-like growth factor-i-induced activation of p70S6 kinase and suppress insulin-like growth factor-I tumor-promoting activity
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28 November 2018
Activation of AMP-activated protein kinase reduces hyperglycemia-induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells
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28 November 2018
Improved clinical outcomes associated with metformin in patients with diabetes and heart failure
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28 November 2018
Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase.
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28 November 2018
Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells
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28 November 2018
Reduced cardiovascular morbidity and mortality associated with metformin use in subjects with Type 2 diabetes
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28 November 2018
Effects of short-term treatment with metformin on markers of endothelial function and inflammatory activity in type 2 diabetes mellitus: a randomized, placebo-controlled trial
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28 November 2018
Thiazolidinediones, like metformin, inhibit respiratory complex I: a common mechanism contributing to their antidiabetic actions?
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28 November 2018
AMP-activated protein kinase regulates HNF4alpha transcriptional activity by inhibiting dimer formation and decreasing protein stability
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28 November 2018
Decreased mortality associated with the use of metformin compared with sulfonylurea monotherapy in type 2 diabetes
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28 November 2018
Obligatory role of membrane events in the regulatory effect of metformin on the respiratory chain function
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28 November 2018
Intrahepatic mechanisms underlying the effect of metformin in decreasing basal glucose production in rats fed a high-fat diet
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28 November 2018
Metformin in non-alcoholic steatohepatitis.
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28 November 2018
Regulation of transcription by AMP-activated protein kinase: phosphorylation of p300 blocks its interaction with nuclear receptors
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28 November 2018
Hepatocyte nuclear factor-4alpha involved in type 1 maturity-onset diabetes of the young is a novel target of AMP-activated protein kinase
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28 November 2018
Prevention of pancreatic cancer induction in hamsters by metformin
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28 November 2018
Evidence that pioglitazone, metformin and pentoxifylline are inhibitors of glycation
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28 November 2018
AMP-activated protein kinase inhibits the glucose-activated expression of fatty acid synthase gene in rat hepatocytes
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28 November 2018
Metformin decreases gluconeogenesis by enhancing the pyruvate kinase flux in isolated rat hepatocytes.
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28 November 2018
Effects of metformin on lactate uptake and gluconeogenesis in the perfused rat liver
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retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Optimizing cardiac fatty acid and glucose metabolism as an approach to treating heart failure
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22117616
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Neither LKB1 nor AMPK are the direct targets of metformin
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22117616
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Accumulation of metformin by tissues of the normal and diabetic mouse
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22117616
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Photoaffinity cross-linking of oligomycin-sensitive ATPase from beef heart mitochondria by 3′-arylazido-8-azido ATP
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22117616
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Metformin: the safest hypoglycaemic agent in chronic kidney disease?
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22117616
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The effects of glucose, insulin and metformin on the order parameters of isolated red cell membranes. An electron paramagnetic resonance spectroscopic study
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22117616
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1042/CS20110386
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
197595
Fatcat ID
release_7hasrmp4u5aozjvh437fej4qni
0 references
OpenCitations bibliographic resource ID
197595
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
197595
PMC publication ID
3398862
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
197595
PubMed publication ID
22117616
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
197595
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