(Q38865951)

English

I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway

scientific article published on 8 June 2015

In more languages

Statements

scholarly article

1 reference

Europe PubMed Central

7 September 2017

I2020T mutant LRRK2 iPSC-derived neurons in the Sagamihara family exhibit increased Tau phosphorylation through the AKT/GSK-3β signaling pathway (English)

1 reference

Europe PubMed Central

7 September 2017

phosphorylation

1 reference

based on heuristic

inferred from title

19

object named as

Hideyuki Okano

1 reference

Europe PubMed Central

7 September 2017

Yoshikuni Mizuno

16

object named as

Yoshikuni Mizuno

1 reference

Europe PubMed Central

7 September 2017

6

object named as

Wado Akamatsu

1 reference

Europe PubMed Central

7 September 2017

Yoichi Imaizumi

4

object named as

Yoichi Imaizumi

1 reference

Europe PubMed Central

7 September 2017

5

object named as

Yohei Okada

1 reference

Europe PubMed Central

7 September 2017

author name string

Etsuro Ohta

1

1 reference

Europe PubMed Central

7 September 2017

Tomoko Nihira

2

1 reference

Europe PubMed Central

7 September 2017

Akiko Uchino

3

1 reference

Europe PubMed Central

7 September 2017

Kayoko Takahashi

7

1 reference

Europe PubMed Central

7 September 2017

Hideki Hayakawa

8

1 reference

Europe PubMed Central

7 September 2017

Makiko Nagai

9

1 reference

Europe PubMed Central

7 September 2017

Manabu Ohyama

10

1 reference

Europe PubMed Central

7 September 2017

Masafuchi Ryo

11

1 reference

Europe PubMed Central

7 September 2017

Mieko Ogino

12

1 reference

Europe PubMed Central

7 September 2017

Shigeo Murayama

13

1 reference

Europe PubMed Central

7 September 2017

Akihiko Takashima

14

1 reference

Europe PubMed Central

7 September 2017

Kazutoshi Nishiyama

15

1 reference

Europe PubMed Central

7 September 2017

Hideki Mochizuki

17

1 reference

Europe PubMed Central

7 September 2017

Fumiya Obata

18

1 reference

Europe PubMed Central

7 September 2017

publication date

8 June 2015

1 reference

Europe PubMed Central

7 September 2017

Human Molecular Genetics

1 reference

Europe PubMed Central

7 September 2017

24

1 reference

Europe PubMed Central

7 September 2017

17

1 reference

Europe PubMed Central

7 September 2017

4879-4900

1 reference

Europe PubMed Central

7 September 2017

Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

An LRRK2 mutation as a cause for the parkinsonism in the original PARK8 family.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Mendelian forms of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

What genetics tells us about the causes and mechanisms of Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Genetic characteristics of leucine-rich repeat kinase 2 (LRRK2) associated Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

The RIP kinases: crucial integrators of cellular stress

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Phosphorylation of LRRK2: from kinase to substrate

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Ribosomal protein s15 phosphorylation mediates LRRK2 neurodegeneration in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Kinase activity of mutant LRRK2 mediates neuronal toxicity

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Investigation of leucine-rich repeat kinase 2 : enzymological properties and novel assays.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Dominant-negative effects of LRRK2 heterodimers: a possible mechanism of neurodegeneration in Parkinson's disease caused by LRRK2 I2020T mutation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

LRRK2 mutant iPSC-derived DA neurons demonstrate increased susceptibility to oxidative stress

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Induction of pluripotent stem cells from adult human fibroblasts by defined factors

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

LRRK2 I2020T mutation is associated with tau pathology.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Familial parkinsonism: study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

The relationship between subcortical tau pathology and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

I(2020)T leucine-rich repeat kinase 2, the causative mutant molecule of familial Parkinson's disease, has a higher intracellular degradation rate than the wild-type molecule

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Prevention of intracellular degradation of I2020T mutant LRRK2 restores its protectivity against apoptosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Evidence that the LRRK2 ROC domain Parkinson's disease-associated mutants A1442P and R1441C exhibit increased intracellular degradation.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Regulation of neuronal survival by the serine-threonine protein kinase Akt

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

AKT/PKB signaling: navigating downstream

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Emerging role of LRRK2 in human neural progenitor cell cycle progression, survival and differentiation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

LRRK2 regulates synaptic vesicle endocytosis

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Presynaptic dysfunction in Parkinson's disease: a focus on LRRK2.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

LRRK2 affects vesicle trafficking, neurotransmitter extracellular level and membrane receptor localization

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

LRRK2 phosphorylates Snapin and inhibits interaction of Snapin with SNAP-25

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Snapin facilitates the synchronization of synaptic vesicle fusion

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Roles of cholesterol and lipids in the etiopathogenesis of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

The renaissance of GSK3

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Oxidative stress in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Generation of human melanocytes from induced pluripotent stem cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Establishment of induced pluripotent stem cells from centenarians for neurodegenerative disease research

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Spatiotemporal recapitulation of central nervous system development by murine embryonic stem cell-derived neural stem/progenitor cells.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

A human Dravet syndrome model from patient induced pluripotent stem cells

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

A single amino acid mutation in SNAP-25 induces anxiety-related behavior in mouse

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

A src family tyrosine kinase inhibits neurotransmitter release from neuronal cells.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Comparison of exocytotic mechanisms between acetylcholine- and catecholamine-containing vesicles in rat pheochromocytoma cells.

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDV212

21 January 2018

Identifiers

10.1093/HMG/DDV212

1 reference

Europe PubMed Central

7 September 2017

1 reference

Europe PubMed Central

7 September 2017

ResearchGate publication ID

0 references

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

Retrieved from "https://www.wikidata.org/w/index.php?title=Q38865951&oldid=1792642251"