(Q38044439)

27 August 2017

title

Phosphorylation of LRRK2: from kinase to substrate (English)

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27 August 2017

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3

Jean-Marc Taymans

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27 August 2017

2

Veerle Baekelandt

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27 August 2017

1

Evy Lobbestael

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27 August 2017

language of work or name

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1 October 2012

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Biochemical Society Transactions

27 August 2017

published in

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27 August 2017

volume

40

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27 August 2017

issue

5

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27 August 2017

page(s)

1102-1110

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Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease

27 August 2017

cites work

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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology

21 January 2018

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LRRK2 in Parkinson's disease: protein domains and functional insights

21 January 2018

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Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions

21 January 2018

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Mechanisms in dominant parkinsonism: The toxic triangle of LRRK2, alpha-synuclein, and tau.

21 January 2018

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Phosphopeptide analysis reveals two discrete clusters of phosphorylation in the N-terminus and the Roc domain of the Parkinson-disease associated protein kinase LRRK2.

21 January 2018

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The Parkinson's disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

21 January 2018

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Identification of the autophosphorylation sites of LRRK2.

21 January 2018

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Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

21 January 2018

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Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson's disease mutations and LRRK2 pharmacological inhibition

21 January 2018

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Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

21 January 2018

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14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

21 January 2018

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Kinases as targets for Parkinson's disease: from genetics to therapy

21 January 2018

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The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

21 January 2018

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Kinase activity of mutant LRRK2 mediates neuronal toxicity

21 January 2018

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Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

21 January 2018

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Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization

21 January 2018

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Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

21 January 2018

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On the road to leucine-rich repeat kinase 2 signalling: evidence from cellular and in vivo studies

21 January 2018

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MAP kinase signalling pathways in cancer

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120128

Autophosphorylation: a salient feature of protein kinases

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120128

The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120128

Membrane localization of LRRK2 is associated with increased formation of the highly active LRRK2 dimer and changes in its phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120128

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

21 January 2018

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Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

21 January 2018

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Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120128

14-3-3 proteins: regulation of subcellular localization by molecular interference

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120128

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1042%2FBST20120128

Molecular pathogenesis of Parkinson disease: insights from genetic studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

GTPase activity plays a key role in the pathobiology of LRRK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

RNA interference of LRRK2-microarray expression analysis of a Parkinson's disease key player

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

Reevaluation of phosphorylation sites in the Parkinson disease-associated leucine-rich repeat kinase 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

Identification of potential protein interactors of Lrrk2

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

Homo- and heterodimerization of ROCO kinases: LRRK2 kinase inhibition by the LRRK2 ROCO fragment

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

Heterodimerization of Lrrk1-Lrrk2: Implications for LRRK2-associated Parkinson disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

The WD40 domain is required for LRRK2 neurotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3ß.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

Expression of leucine-rich repeat kinase 2 (LRRK2) inhibits the processing of uMtCK to induce cell death in a cell culture model system

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

Caenorhabditits elegans LRK-1 and PINK-1 act antagonistically in stress response and neurite outgrowth

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBST20120128

21 January 2018

Identifiers

DOI

10.1042/BST20120128

1 reference

27 August 2017

1 reference