(Q38886445)

7 September 2017

title

Dissociation of Bak α1 helix from the core and latch domains is required for apoptosis (English)

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7 September 2017

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6

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7 September 2017

Amber E Alsop

1

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7 September 2017

Stephanie C Fennell

2

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7 September 2017

Ray C Bartolo

3

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7 September 2017

Iris K L Tan

4

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7 September 2017

Grant Dewson

5

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7 September 2017

language of work or name

English

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publication date

16 April 2015

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7 September 2017

published in

Nature Communications

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7 September 2017

volume

6

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7 September 2017

page(s)

6841

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Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.

7 September 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Structure of Bax: coregulation of dimer formation and intracellular localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Cytosolic factor- and TOM-independent import of C-tail-anchored mitochondrial outer membrane proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Conformation of the Bax C-terminus regulates subcellular location and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

BID-induced structural changes in BAK promote apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Bax dimerizes via a symmetric BH3:groove interface during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Molecular biology of Bax and Bak activation and action

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Structural model of active Bax at the membrane.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Conformational changes in BAK, a pore-forming proapoptotic Bcl-2 family member, upon membrane insertion and direct evidence for the existence of BH3-BH3 contact interface in BAK homo-oligomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

VDAC2 inhibits BAK activation and mitochondrial apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Strategies for epitope analysis using peptide synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

BIM-mediated membrane insertion of the BAK pore domain is an essential requirement for apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Organization of the mitochondrial apoptotic BAK pore: oligomerization of the BAK homodimers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

A unified model of mammalian BCL-2 protein family interactions at the mitochondria.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

BCL-2 Selectively Interacts with the BID-induced Open Conformer of BAK, Inhibiting BAK Auto-oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Inhibition of Bak activation by VDAC2 is dependent on the Bak transmembrane anchor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

On the sequential determinants of calpain cleavage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Elucidation of some Bax conformational changes through crystallization of an antibody-peptide complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

The NCI60 human tumour cell line anticancer drug screen

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Bak apoptotic function is not directly regulated by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Chlamydia trachomatis infection inhibits both Bax and Bak activation induced by staurosporine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

Nonionic detergents induce dimerization among members of the Bcl-2 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNCOMMS7841

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NCOMMS7841

1 reference

Dimensions Publication ID

7 September 2017

0 references

1033827337

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Fatcat ID

release_kpz62ez6gja5jdi64zpohifzye

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/kpz62ez6gja5jdi64zpohifzye

mapped directly with Wikidata item

24 November 2022

based on heuristic

1 reference