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Structural model of active Bax at the membrane.
scientific article published on 30 October 2014
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scholarly article
1 reference
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Europe PubMed Central
PMC publication ID
4869853
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25458844%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 February 2020
title
Structural model of active Bax at the membrane
(English)
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stated in
Europe PubMed Central
PMC publication ID
4869853
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25458844%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 February 2020
author
Stephanie Bleicken
series ordinal
1
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Europe PubMed Central
PMC publication ID
4869853
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25458844%20AND%20SRC:MED&resulttype=core&format=json
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24 February 2020
Ana J García-Sáez
series ordinal
5
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Europe PubMed Central
PMC publication ID
4869853
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25458844%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 February 2020
author name string
Gunnar Jeschke
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2
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PMC publication ID
4869853
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25458844%20AND%20SRC:MED&resulttype=core&format=json
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24 February 2020
Carolin Stegmueller
series ordinal
3
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PMC publication ID
4869853
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25458844%20AND%20SRC:MED&resulttype=core&format=json
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24 February 2020
Raquel Salvador-Gallego
series ordinal
4
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Europe PubMed Central
PMC publication ID
4869853
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25458844%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 February 2020
Enrica Bordignon
series ordinal
6
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Europe PubMed Central
PMC publication ID
4869853
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25458844%20AND%20SRC:MED&resulttype=core&format=json
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24 February 2020
language of work or name
English
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publication date
30 October 2014
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Europe PubMed Central
PMC publication ID
4869853
reference URL
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retrieved
24 February 2020
published in
Molecular Cell
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Europe PubMed Central
PMC publication ID
4869853
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25458844%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 February 2020
volume
56
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Europe PubMed Central
PMC publication ID
4869853
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25458844%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 February 2020
issue
4
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Europe PubMed Central
PMC publication ID
4869853
reference URL
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24 February 2020
page(s)
496-505
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Europe PubMed Central
PMC publication ID
4869853
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25458844%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 February 2020
cites work
Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
After embedding in membranes antiapoptotic Bcl-XL protein binds both Bcl-2 homology region 3 and helix 1 of proapoptotic Bax protein to inhibit apoptotic mitochondrial permeabilization.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Organization of the mitochondrial apoptotic BAK pore: oligomerization of the BAK homodimers
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Proapoptotic Bax and Bak proteins form stable protein-permeable pores of tunable size
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Conformational dynamics and distribution of nitroxide spin labels
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Bax exists in a dynamic equilibrium between the cytosol and mitochondria to control apoptotic priming
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
The secrets of the Bcl-2 family
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Dynamic interaction of cBid with detergents, liposomes and mitochondria.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Bax dimerizes via a symmetric BH3:groove interface during apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Rotamer libraries of spin labelled cysteines for protein studies
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
BH3-triggered structural reorganization drives the activation of proapoptotic BAX.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Bax forms an oligomer via separate, yet interdependent, surfaces
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Bax contains two functional mitochondrial targeting sequences and translocates to mitochondria in a conformational change- and homo-oligomerization-driven process
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Conformational changes and protein stability of the pro-apoptotic protein Bax.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
BAX activation is initiated at a novel interaction site
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
The BCL-2 protein family: opposing activities that mediate cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Interaction with a membrane surface triggers a reversible conformational change in Bax normally associated with induction of apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Bax and Bak coalesce into novel mitochondria-associated clusters during apoptosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Structure of Bax: coregulation of dimer formation and intracellular localization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Conformation of the Bax C-terminus regulates subcellular location and cell death
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
26 October 2017
Mechanistic differences in the membrane activity of Bax and Bcl-xL correlate with their opposing roles in apoptosis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
17 August 2018
High sensitivity and versatility of the DEER experiment on nitroxide radical pairs at Q-band frequencies.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
17 August 2018
DEER distance measurements on proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
17 August 2018
Molecular details of Bax activation, oligomerization, and membrane insertion.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
17 August 2018
Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
17 August 2018
Peptides corresponding to helices 5 and 6 of Bax can independently form large lipid pores
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4869853
retrieved
1 December 2018
Membrane-insertion fragments of Bcl-xL, Bax, and Bid
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25458844
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.MOLCEL.2014.09.022
1 reference
stated in
Europe PubMed Central
PMC publication ID
4869853
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25458844%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 February 2020
PMC publication ID
4869853
1 reference
stated in
Europe PubMed Central
PMC publication ID
4869853
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25458844%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 February 2020
PubMed publication ID
25458844
1 reference
stated in
Europe PubMed Central
PMC publication ID
4869853
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25458844%20AND%20SRC:MED&resulttype=core&format=json
retrieved
24 February 2020
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