(Q33569749)

English

Bax contains two functional mitochondrial targeting sequences and translocates to mitochondria in a conformational change- and homo-oligomerization-driven process

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Bax contains two functional mitochondrial targeting sequences and translocates to mitochondria in a conformational change- and homo-oligomerization-driven process (English)

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

1 reference

based on heuristic

inferred from title

author name string

Nicholas M George

1

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Natalie Targy

2

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Jacquelynn J D Evans

3

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Liqiang Zhang

4

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Xu Luo

5

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

language of work or name

0 references

publication date

30 October 2009

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

285

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

2

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

1384-1392

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

BAX activation is initiated at a novel interaction site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Bax targeting to mitochondria occurs via both tail anchor-dependent and -independent mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Cysteine 62 of Bax is critical for its conformational activation and its proapoptotic activity in response to H2O2-induced apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

The BCL-2 protein family: opposing activities that mediate cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

A three-helix homo-oligomerization domain containing BH3 and BH1 is responsible for the apoptotic activity of Bax.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Bcl-2-regulated apoptosis: mechanism and therapeutic potential

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

A stapled BID BH3 helix directly binds and activates BAX

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

The multidomain proapoptotic molecules Bax and Bak are directly activated by heat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Life in the balance: how BH3-only proteins induce apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Bax forms multispanning monomers that oligomerize to permeabilize membranes during apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

The first alpha helix of Bax plays a necessary role in its ligand-induced activation by the BH3-only proteins Bid and PUMA.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

The pathophysiology of mitochondrial cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Cytochrome C-mediated apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Conformational control of Bax localization and apoptotic activity by Pro168.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Structural biology of the Bcl-2 family of proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Cell death: critical control points

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Ways of dying: multiple pathways to apoptosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Spatial and temporal changes in Bax subcellular localization during anoikis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

The N-terminal end of Bax contains a mitochondrial-targeting signal.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

The Bcl2 family: regulators of the cellular life-or-death switch

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

BH3-Only proteins-essential initiators of apoptotic cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Structure of Bax: coregulation of dimer formation and intracellular localization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Withdrawal of IL-7 induces Bax translocation from cytosol to mitochondria through a rise in intracellular pH.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Conformation of the Bax C-terminus regulates subcellular location and cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Regulated targeting of BAX to mitochondria.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Bax directly induces release of cytochrome c from isolated mitochondria

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Movement of Bax from the cytosol to mitochondria during apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Functional domains of the transcription factor USF2: atypical nuclear localization signals and context-dependent transcriptional activation domains

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2801264

21 June 2018

Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.049924

21 January 2018

Involvement of the N-terminus of Bax in its intracellular localization and function.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.049924

21 January 2018

Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.049924

21 January 2018

Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19880508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Helix 6 of tBid is necessary but not sufficient for mitochondrial binding activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19880508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiolipin provides specificity for targeting of tBid to mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/19880508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

BID-dependent and BID-independent pathways for BAX insertion into mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/19880508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A 15-residue bifunctional element in D-AKAP1 is required for both endoplasmic reticulum and mitochondrial targeting

1 reference

https://pubmed.ncbi.nlm.nih.gov/19880508

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M109.049924

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

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