(Q38904777)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25728708%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

title

Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK (English)

1 reference

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1 March 2020

0 references

8

1 reference

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1 March 2020

Maarten Altelaar

11

1 reference

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1 March 2020

10

Jos H Beijnen

1 reference

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1 March 2020

2

Marjon A Smit

1 reference

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1 March 2020

3

Gianluca Maddalo

1 reference

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1 March 2020

4

Patricia A Possik

1 reference

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1 March 2020

12

Daniel S Peeper

1 reference

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1 March 2020

Sjoerd H van der Burg

6

object named as

Sjoerd H van der Burg

1 reference

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1 March 2020

author name string

Celia J Vogel

1

1 reference

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1 March 2020

Rolf W Sparidans

5

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1 March 2020

Els M Verdegaal

7

1 reference

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1 March 2020

Ahmed A Samatar

9

1 reference

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1 March 2020

publication date

6 April 2015

1 reference

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Pigment Cell & Melanoma Research

1 March 2020

published in

1 reference

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1 March 2020

volume

28

1 reference

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1 March 2020

page(s)

307-317

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1 March 2020

issue

3

1 reference

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Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties

1 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Next-generation proteomics: towards an integrative view of proteome dynamics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Down-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Structure-guided design of potent and selective pyrimidylpyrrole inhibitors of extracellular signal-regulated kinase (ERK) using conformational control

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Improved survival with vemurafenib in melanoma with BRAF V600E mutation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

In vivo activation of ROCK1 by insulin is impaired in skeletal muscle of humans with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Transcriptional pathway signatures predict MEK addiction and response to selumetinib (AZD6244)

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

NRAS mutant melanoma: biological behavior and future strategies for therapeutic management

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Effective inhibition of melanoma by BI-69A11 is mediated by dual targeting of the AKT and NF-κB pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

BRAF inhibition is associated with enhanced melanoma antigen expression and a more favorable tumor microenvironment in patients with metastatic melanoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

GSK1120212 (JTP-74057) is an inhibitor of MEK activity and activation with favorable pharmacokinetic properties for sustained in vivo pathway inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Genotype-selective combination therapies for melanoma identified by high-throughput drug screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

RacGAP1 expression, increasing tumor malignant potential, as a predictive biomarker for lymph node metastasis and poor prognosis in colorectal cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Targeting the RAS pathway in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Ras oncogenes: split personalities

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Analysis of 20 genes at chromosome band 12q13: RACGAP1 and MCRS1 overexpression in nonsmall-cell lung cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Changes in Ect2 localization couple actomyosin-dependent cell shape changes to mitotic progression

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Discovery of a novel ERK inhibitor with activity in models of acquired resistance to BRAF and MEK inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Effect of Wf-536, a novel ROCK inhibitor, against metastasis of B16 melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Identification of direct transcriptional targets of (V600E)BRAF/MEK signalling in melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Vertical inhibition of the MAPK pathway enhances therapeutic responses in NRAS-mutant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Improved overall survival in melanoma with combined dabrafenib and trametinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

ROCK1 is a potential combinatorial drug target for BRAF mutant melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Ubiquitination and downregulation of BRCA1 by ubiquitin-conjugating enzyme E2T overexpression in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

The PRoteomics IDEntifications (PRIDE) database and associated tools: status in 2013

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Mutant NRASQ61 shares signaling similarities across various cancer types--potential implications for future therapies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Delving into somatic variation in sporadic melanoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

Regulation of UHRF1 by miR-146a/b modulates gastric cancer invasion and metastasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FPCMR.12364

21 January 2018

Identifiers

DOI

10.1111/PCMR.12364

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25728708%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

1 reference