(Q38909429)

7 September 2017

Regulation of suppressors of cytokine signaling as a therapeutic approach in autoimmune diseases, with an emphasis on multiple sclerosis (English)

1 reference

7 September 2017

0 references

2

Silva Markovic-Plese

0 references

author name string

Vinod S Ramgolam

series ordinal

1

1 reference

PMC publication ID

3206360

7 September 2017

Silva Markovic-Plese

series ordinal

2

1 reference

7 September 2017

1 November 2011

1 reference

Journal of Signal Transduction

7 September 2017

1 reference

7 September 2017

2011

1 reference

7 September 2017

635721

1 reference

Creative Commons Attribution 3.0 Unported

7 September 2017

start time

1 November 2011

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

1 reference

April 2022 Public Data File from Crossref

cites work

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A type I interferon signature in monocytes is associated with poor response to interferon-beta in multiple sclerosis

9 September 2017

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Mutations in STAT3 and IL12RB1 impair the development of human IL-17-producing T cells

9 September 2017

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Deficiency of Th17 cells in hyper IgE syndrome due to mutations in STAT3

9 September 2017

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The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice

9 September 2017

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The Th17-ELR+ CXC chemokine pathway is essential for the development of central nervous system autoimmune disease

9 September 2017

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Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis

9 September 2017

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Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

9 September 2017

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Distinct regulation of interleukin-17 in human T helper lymphocytes

9 September 2017

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Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells

9 September 2017

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Development, cytokine profile and function of human interleukin 17-producing helper T cells

9 September 2017

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Phenotypic and functional features of human Th17 cells

9 September 2017

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SOCS proteins, cytokine signalling and immune regulation

9 September 2017

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TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1.

9 September 2017

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Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells

9 September 2017

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STAT3 regulates cytokine-mediated generation of inflammatory helper T cells

9 September 2017

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Defective Hepatic Response to Interferon and Activation of Suppressor of Cytokine Signaling 3 in Chronic Hepatitis C

9 September 2017

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IL-17 family cytokines and the expanding diversity of effector T cell lineages

9 September 2017

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IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production

9 September 2017

1 reference

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Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

9 September 2017

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

9 September 2017

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HMG-CoA reductase inhibitors suppress maturation of human dendritic cells: new implications for atherosclerosis

9 September 2017

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Suppressors of cytokine signaling and immunity

9 September 2017

1 reference

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SOCS3 negatively regulates IL-6 signaling in vivo

9 September 2017

1 reference

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Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

9 September 2017

1 reference

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Lineage commitment in the immune system: the T helper lymphocyte grows up.

9 September 2017

1 reference

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SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality

9 September 2017

1 reference

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Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis

9 September 2017

1 reference

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Structure and function of a new STAT-induced STAT inhibitor

9 September 2017

1 reference

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A family of cytokine-inducible inhibitors of signalling

9 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

IFN-beta-induced SOCS-1 negatively regulates CD40 gene expression in macrophages and microglia

9 September 2017

1 reference

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Treatment of mice with the suppressor of cytokine signaling-1 mimetic peptide, tyrosine kinase inhibitor peptide, prevents development of the acute form of experimental allergic encephalomyelitis and induces stable remission in the chronic relapsing

14 September 2017

1 reference

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Role of tyrosine 441 of interferon-gamma receptor subunit 1 in SOCS-1-mediated attenuation of STAT1 activation

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

Suppressor of cytokine signaling 1 inhibits cytokine induction of CD40 expression in macrophages

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

Simvastatin inhibits IFN regulatory factor 4 expression and Th17 cell differentiation in CD4+ T cells derived from patients with multiple sclerosis.

25 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

A cytokine gene screen uncovers SOCS1 as genetic risk factor for multiple sclerosis

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

IFN-beta inhibits human Th17 cell differentiation

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-beta.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

IFN-beta1a inhibits the secretion of Th17-polarizing cytokines in human dendritic cells via TLR7 up-regulation.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

Oligoclonal myelin-reactive T-cell infiltrates derived from multiple sclerosis lesions are enriched in Th17 cells.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

Increased IL-23p19 expression in multiple sclerosis lesions and its induction in microglia.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

Oral simvastatin treatment in relapsing-remitting multiple sclerosis

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

Statins induce suppressor of cytokine signaling-3 in macrophages

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

IFN-beta gene deletion leads to augmented and chronic demyelinating experimental autoimmune encephalomyelitis.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

SOCS1 is a critical inhibitor of interferon gamma signaling and prevents the potentially fatal neonatal actions of this cytokine.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

Production of endogenous interferon-alpha and beta in patients with multiple sclerosis

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3206360

A single focus of multiple sclerosis in the cervical spinal cord mimicking a radiculopathy

22 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1155%2F2011%2F635721

Distinct and Nonredundant In Vivo Functions of IFNAR on Myeloid Cells Limit Autoimmunity in the Central Nervous System

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1155%2F2011%2F635721

Randomised double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1155%2F2011%2F635721

Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis

21 January 2018

1 reference

12 December 2020

Randomised double-blind placebo-controlled study of interferon beta-1a in relapsing/remitting multiple sclerosis. PRISMS (Prevention of Relapses and Disability by Interferon beta-1a Subcutaneously in Multiple Sclerosis) Study Group

1 reference

12 December 2020

SOCS-1 participates in negative regulation of LPS responses

1 reference

12 December 2020

Immunomodulatory effects of interferon beta-1a in multiple sclerosis

1 reference

12 December 2020

Cholesterol-lowering statins possess anti-inflammatory activity that might be useful for treatment of MS

1 reference

12 December 2020

The effect of disease activity on leptin, leptin receptor and suppressor of cytokine signalling-3 expression in relapsing-remitting multiple sclerosis

1 reference

12 December 2020

SOCS1/JAB is a negative regulator of LPS-induced macrophage activation

1 reference

12 December 2020

Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads

1 reference

12 December 2020

Statins as a newly recognized type of immunomodulator

1 reference

12 December 2020

Interferon-? therapy for multiple sclerosis induces reciprocal changes in interleukin-12 and interleukin-10 production

1 reference

12 December 2020

B cells as a therapeutic target for IFN-β in relapsing-remitting multiple sclerosis

1 reference

12 December 2020

Suppressor of cytokine Signaling-3 inhibits interleukin-1 signaling by targeting the TRAF-6/TAK1 complex

1 reference

12 December 2020

Increased IL-10 mRNA and IL-23 mRNA expression in multiple sclerosis: interferon-beta treatment increases IL-10 mRNA expression while reducing IL-23 mRNA expression

1 reference

12 December 2020

Immunology of multiple sclerosis

1 reference

12 December 2020

Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: results of a phase II clinical trial with an altered peptide ligand

1 reference

12 December 2020

Identifiers

DOI

10.1155/2011/635721

1 reference

7 September 2017

1 reference

PMC publication ID

3206360

7 September 2017

PubMed publication ID

22132325

1 reference

PMC publication ID

3206360