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Epigenetic Mechanisms of Longevity and Aging.
scientific article published on August 2016
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Europe PubMed Central
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5821249
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20 March 2020
review article
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title
Epigenetic Mechanisms of Longevity and Aging
(English)
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Europe PubMed Central
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5821249
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27518561%20AND%20SRC:MED&resulttype=core&format=json
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20 March 2020
author
Shelley L. Berger
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4
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20 March 2020
author name string
Payel Sen
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1
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5821249
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20 March 2020
Parisha P Shah
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2
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20 March 2020
Raffaella Nativio
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3
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20 March 2020
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English
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publication date
1 August 2016
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20 March 2020
published in
Cell
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20 March 2020
volume
166
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20 March 2020
issue
4
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20 March 2020
page(s)
822-839
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20 March 2020
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17 June 2018
Chromatin remodeling in the aging genome of Drosophila
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17 June 2018
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17 June 2018
Post-translational modification of cellular proteins by ubiquitin and ubiquitin-like molecules: role in cellular senescence and aging.
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17 June 2018
Ageing in Drosophila: the role of the insulin/Igf and TOR signalling network
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17 June 2018
Elevated Histone Expression Promotes Life Span Extension
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17 June 2018
Progeria syndromes and ageing: what is the connection?
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17 June 2018
Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans
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17 June 2018
Drosophila melanogaster in the study of human neurodegeneration
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17 June 2018
The genetics of ageing
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17 June 2018
Regulation of lifespan, metabolism, and stress responses by the Drosophila SH2B protein, Lnk
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17 June 2018
Molecular evolution and functional characterization of Drosophila insulin-like peptides
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17 June 2018
Polycomb Repressive Complex 2 and Trithorax modulate Drosophila longevity and stress resistance
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17 June 2018
Healing and hurting: molecular mechanisms, functions, and pathologies of cellular senescence
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17 June 2018
Induction of autophagy by spermidine promotes longevity
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17 June 2018
Ageing-related chromatin defects through loss of the NURD complex
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17 June 2018
Calorie restriction and the exercise of chromatin
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17 June 2018
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
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17 June 2018
Histone H4 lysine 16 acetylation regulates cellular lifespan
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17 June 2018
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
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17 June 2018
Probing nucleosome function: a highly versatile library of synthetic histone H3 and H4 mutants
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17 June 2018
High basal metabolic rate is a risk factor for mortality: the Baltimore Longitudinal Study of Aging.
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17 June 2018
A comprehensive library of histone mutants identifies nucleosomal residues required for H3K4 methylation
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17 June 2018
Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin
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17 June 2018
Phenotype and course of Hutchinson-Gilford progeria syndrome
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17 June 2018
Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans
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17 June 2018
An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans
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17 June 2018
Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation
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17 June 2018
Recent developments in yeast aging
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17 June 2018
Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases.
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17 June 2018
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
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PubMed Central
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17 June 2018
Rtt109 acetylates histone H3 lysine 56 and functions in DNA replication
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17 June 2018
Yeast Rtt109 promotes genome stability by acetylating histone H3 on lysine 56
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17 June 2018
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
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17 June 2018
Molecular dissection of formation of senescence-associated heterochromatin foci
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17 June 2018
Nucleus-vacuole junctions and piecemeal microautophagy of the nucleus in S. cerevisiae
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17 June 2018
Resveratrol improves health and survival of mice on a high-calorie diet
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17 June 2018
Sirtuins in aging and age-related disease.
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17 June 2018
Increased cell-to-cell variation in gene expression in ageing mouse heart
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PubMed Central
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17 June 2018
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
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17 June 2018
Lamin A-dependent nuclear defects in human aging
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17 June 2018
Rate of Growth and Length of Life
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17 June 2018
TOR signaling in growth and metabolism
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17 June 2018
Extension of chronological life span in yeast by decreased TOR pathway signaling
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17 June 2018
Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients
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17 June 2018
A systematic RNAi screen for longevity genes in C. elegans
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17 June 2018
Calorie restriction, SIRT1 and metabolism: understanding longevity
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PubMed Central
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17 June 2018
Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome
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17 June 2018
The plasticity of aging: insights from long-lived mutants
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17 June 2018
Life extension in the dwarf mouse
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17 June 2018
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
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17 June 2018
Prelamin A endoproteolytic processing in vitro by recombinant Zmpste24
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17 June 2018
Murine models of life span extension
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17 June 2018
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
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17 June 2018
Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity
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PubMed Central
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17 June 2018
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
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PubMed Central
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17 June 2018
Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome
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17 June 2018
Temporal linkage between the phenotypic and genomic responses to caloric restriction
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17 June 2018
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
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PubMed Central
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17 June 2018
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
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17 June 2018
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
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17 June 2018
Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome
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17 June 2018
Lamin a truncation in Hutchinson-Gilford progeria.
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17 June 2018
SOD2 functions downstream of Sch9 to extend longevity in yeast
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
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17 June 2018
Aging results in hypermethylation of ribosomal DNA in sperm and liver of male rats
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
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17 June 2018
The tor pathway regulates gene expression by linking nutrient sensing to histone acetylation
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PubMed Central
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17 June 2018
Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect.
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PubMed Central
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17 June 2018
Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging.
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PubMed Central
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17 June 2018
The genome-wide localization of Rsc9, a component of the RSC chromatin-remodeling complex, changes in response to stress
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17 June 2018
Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
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17 June 2018
If you would live long, choose your parents well
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17 June 2018
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
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17 June 2018
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
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17 June 2018
Regulation of longevity and stress resistance by Sch9 in yeast
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17 June 2018
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
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17 June 2018
Delayed aging in Ames dwarf mice. Relationships to endocrine function and body size.
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17 June 2018
Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1.
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17 June 2018
Mutations in signal transduction proteins increase stress resistance and longevity in yeast, nematodes, fruit flies, and mammalian neuronal cells
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17 June 2018
The p66shc adaptor protein controls oxidative stress response and life span in mammals
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17 June 2018
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
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17 June 2018
Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae.
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17 June 2018
Extrachromosomal rDNA circles--a cause of aging in yeast
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17 June 2018
A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
17 June 2018
daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
17 June 2018
The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
17 June 2018
daf-2 , an Insulin Receptor-Like Gene That Regulates Longevity and Diapause in Caenorhabditis elegans
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
17 June 2018
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
17 June 2018
A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
17 June 2018
A C. elegans mutant that lives twice as long as wild type
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
17 June 2018
Mutation in the silencing gene S/R4 can delay aging in S. cerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
17 June 2018
DNA methylation in aging of mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
17 June 2018
The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
17 June 2018
Inherited Ateliotic Dwarfism in Mice: Characteristics of the mutation, little, on Chromosome 6
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
17 June 2018
RNA-seq of the aging brain in the short-lived fish N. furzeri - conserved pathways and novel genes associated with neurogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
22 August 2018
Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
22 August 2018
The Fruit Fly Drosophila melanogaster as a Model for Aging Research.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
22 August 2018
Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
22 August 2018
Overexpression of SUMO perturbs the growth and development of Caenorhabditis elegans.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
22 August 2018
Inactivation of the Sas2 histone acetyltransferase delays senescence driven by telomere dysfunction.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
22 August 2018
Transcriptional instability is not a universal attribute of aging.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
22 August 2018
Caenorhabditis elegans integrates food and reproductive signals in lifespan determination.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
22 August 2018
RLE-1, an E3 ubiquitin ligase, regulates C. elegans aging by catalyzing DAF-16 polyubiquitination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
22 August 2018
Aging-associated vascular phenotype in mutant mice with low levels of BubR1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
22 August 2018
Mutant mice with small amounts of BubR1 display accelerated age-related gliosis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
22 August 2018
Cellular senescence in aging primates.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
22 August 2018
Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
22 August 2018
Drosophila longevity is not affected by heterochromatin-mediated gene silencing.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
22 August 2018
DNA methyltransferase gene dDnmt2 and longevity of Drosophila
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
22 August 2018
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
22 August 2018
Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
22 August 2018
Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
22 August 2018
Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
2 December 2018
Human longevity at the cost of reproductive success
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5821249
retrieved
2 December 2018
Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27518561
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/27518561
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CELL.2016.07.050
1 reference
stated in
Europe PubMed Central
PMC publication ID
5821249
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27518561%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 March 2020
PMC publication ID
5821249
1 reference
stated in
Europe PubMed Central
PMC publication ID
5821249
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27518561%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 March 2020
PubMed publication ID
27518561
1 reference
stated in
Europe PubMed Central
PMC publication ID
5821249
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27518561%20AND%20SRC:MED&resulttype=core&format=json
retrieved
20 March 2020
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