(Q34127512)

31 July 2017

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title

Progeria syndromes and ageing: what is the connection? (English)

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31 July 2017

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Christopher R Burtner

series ordinal

1

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31 July 2017

Brian K Kennedy

series ordinal

2

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31 July 2017

language of work or name

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1 August 2010

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Nature Reviews Molecular Cell Biology

31 July 2017

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31 July 2017

11

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31 July 2017

567-578

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31 July 2017

8

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https://scigraph.springernature.com/pub.10.1038/nrm2944

31 July 2017

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases.

31 March 2020

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31 March 2020

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Hutchinson-Gilford progeria syndrome

31 March 2020

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Lamin a truncation in Hutchinson-Gilford progeria.

31 March 2020

1 reference

Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes.

31 March 2020

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Role of A-type lamins in signaling, transcription, and chromatin organization.

31 March 2020

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Lamin A/C and emerin are critical for skeletal muscle satellite cell differentiation

31 March 2020

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A mechanism of AP-1 suppression through interaction of c-Fos with lamin A/C.

31 March 2020

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31 March 2020

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31 March 2020

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Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

31 March 2020

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Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

31 March 2020

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Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment

31 March 2020

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Novel roles for A-type lamins in telomere biology and the DNA damage response pathway.

31 March 2020

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Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome

31 March 2020

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Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients

31 March 2020

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Correction of cellular phenotypes of Hutchinson-Gilford Progeria cells by RNA interference

31 March 2020

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DNA damage responses in progeroid syndromes arise from defective maturation of prelamin A.

31 March 2020

1 reference

Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A.

31 March 2020

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Genomic instability in laminopathy-based premature aging

31 March 2020

1 reference

Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice.

31 March 2020

1 reference

Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation.

31 March 2020

1 reference

Suppression of proliferative defects associated with processing-defective lamin A mutants by hTERT or inactivation of p53.

31 March 2020

1 reference

Accelerated telomere shortening and replicative senescence in human fibroblasts overexpressing mutant and wild-type lamin A.

31 March 2020

1 reference

Perturbation of wild-type lamin A metabolism results in a progeroid phenotype

31 March 2020

1 reference

Lamin A-dependent nuclear defects in human aging

31 March 2020

1 reference

A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells

31 March 2020

1 reference

The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin

31 March 2020

1 reference

LMNA mutation in a 45 year old Japanese subject with Hutchinson-Gilford progeria syndrome.

31 March 2020

1 reference

The retinoblastoma gene product is a cell cycle-dependent, nuclear matrix-associated protein

31 March 2020

1 reference

G1/S phosphorylation of the retinoblastoma protein is associated with an altered affinity for the nuclear compartment

31 March 2020

1 reference

Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein

31 March 2020

1 reference

A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation

31 March 2020

1 reference

Stabilization of the retinoblastoma protein by A-type nuclear lamins is required for INK4A-mediated cell cycle arrest

31 March 2020

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Decreased and aberrant nuclear lamin expression in gastrointestinal tract neoplasms

31 March 2020

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Tethering by lamin A stabilizes and targets the ING1 tumour suppressor

31 March 2020

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Telomeres shorten during ageing of human fibroblasts

31 March 2020

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A DNA damage checkpoint response in telomere-initiated senescence

31 March 2020

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Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

31 March 2020

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Telomere length predicts replicative capacity of human fibroblasts

31 March 2020

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Telomere length in Hutchinson-Gilford progeria syndrome

31 March 2020

1 reference

Changes in lamina structure are followed by spatial reorganization of heterochromatic regions in caspase-8-activated human mesenchymal stem cells.

31 March 2020

1 reference

The nuclear lamina promotes telomere aggregation and centromere peripheral localization during senescence of human mesenchymal stem cells.

31 March 2020

1 reference

A-type lamin complexes and regenerative potential: a step towards understanding laminopathic diseases?

31 March 2020

1 reference

HIV protease inhibitors block adipocyte differentiation independently of lamin A/C.

31 March 2020

1 reference

Lamin A/C expression is a marker of mouse and human embryonic stem cell differentiation.

31 March 2020

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Nuclear envelope defects cause stem cell dysfunction in premature-aging mice

31 March 2020

1 reference

PLEIOTROPY, NATURAL SELECTION, AND THE EVOLUTION OF SENESCENCE

31 March 2020

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31 March 2020

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Werner Syndrome, aging and cancer

31 March 2020

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Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance

31 March 2020

1 reference

DNA damage and ageing: new-age ideas for an age-old problem

31 March 2020

1 reference

Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity

31 March 2020

1 reference

Impaired genome maintenance suppresses the growth hormone--insulin-like growth factor 1 axis in mice with Cockayne syndrome

31 March 2020

1 reference

Delayed and accelerated aging share common longevity assurance mechanisms

31 March 2020

1 reference

Prelamin A farnesylation and progeroid syndromes

31 March 2020

1 reference

The truncated prelamin A in Hutchinson-Gilford progeria syndrome alters segregation of A-type and B-type lamin homopolymers

31 March 2020

1 reference

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging.

31 March 2020

1 reference

Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated.

31 March 2020

1 reference

Mutation spectrum of the retinoblastoma gene in osteosarcomas

31 March 2020

1 reference

12 December 2020

Differential timing of nuclear lamin A/C expression in the various organs of the mouse embryo and the young animal: a developmental study.

1 reference

12 December 2020

TOR2 is part of two related signaling pathways coordinating cell growth in Saccharomyces cerevisiae

1 reference

12 December 2020

Osteosarcoma in a patient with Hutchinson-Gilford progeria

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12 December 2020

The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935

1 reference

12 December 2020

The evolution of ageing and longevity

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12 December 2020

Differential expression of nuclear envelope lamins A and C in human lung cancer cell lines

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12 December 2020

Nuclear A-type lamins are differentially expressed in human lung cancer subtypes

1 reference

12 December 2020

A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility

1 reference

12 December 2020

Werner's syndrome a review of its symptomatology, natural history, pathologic features, genetics and relationship to the natural aging process

1 reference

12 December 2020

Complex formation between lamin A and the retinoblastoma gene product: identification of the domain on lamin A required for its interaction

1 reference

12 December 2020

Lamin A/C, laminopathies and premature ageing

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRM2944

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Dimensions Publication ID

31 July 2017

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