(Q38945956)

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CXCR4 tropic human immunodeficiency virus type 1 induces an apoptotic cascade in immature infected thymocytes that resembles thymocyte negative selection

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7 September 2017

CXCR4 tropic human immunodeficiency virus type 1 induces an apoptotic cascade in immature infected thymocytes that resembles thymocyte negative selection (English)

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Europe PubMed Central

PubMed publication ID

7 September 2017

apoptotic process

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Shailesh K Choudhary

1

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Europe PubMed Central

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7 September 2017

Russell M Walker

2

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Europe PubMed Central

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7 September 2017

Douglas M Powell

3

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Europe PubMed Central

PubMed publication ID

7 September 2017

Vicente Planelles

4

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Europe PubMed Central

PubMed publication ID

7 September 2017

Craig Walsh

5

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7 September 2017

David Camerini

6

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7 September 2017

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publication date

14 June 2006

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7 September 2017

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7 September 2017

352

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Europe PubMed Central

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7 September 2017

2

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Europe PubMed Central

PubMed publication ID

7 September 2017

268-284

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Europe PubMed Central

PubMed publication ID

7 September 2017

CD40 activation induces apoptosis in cultured human hepatocytes via induction of cell surface fas ligand expression and amplifies fas-mediated hepatocyte death during allograft rejection

1 reference

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ATR and GADD45alpha mediate HIV-1 Vpr-induced apoptosis

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Glucocorticoids in T cell development and function*.

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Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT)

1 reference

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HIV induces thymus depletion in vivo

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Development of a human thymic organ culture model for the study of HIV pathogenesis

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CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract

1 reference

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Generation of HIV latency during thymopoiesis

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Molecular Characterization, Reactivation, and Depletion of Latent HIV

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A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection

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Human immunodeficiency virus type 1 pathogenesis in SCID-hu mice correlates with syncytium-inducing phenotype and viral replication

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Alternative, nonapoptotic programmed cell death: mediation by arrestin 2, ERK2, and Nur77.

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Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis

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HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8

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R5 human immunodeficiency virus type 1 infection of fetal thymic organ culture induces cytokine and CCR5 expression

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Impact on genetic networks in human macrophages by a CCR5 strain of human immunodeficiency virus type 1

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Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100

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Changes in thymic function with age and during the treatment of HIV infection

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Separation of human immunodeficiency virus type 1 replication from nef-mediated pathogenesis in the human thymus

1 reference

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7 January 2021

Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

1 reference

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7 January 2021

HIV-1 directly kills CD4+ T cells by a Fas-independent mechanism

1 reference

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7 January 2021

HIV-1 and the thymus

1 reference

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7 January 2021

The pathophysiology of mitochondrial cell death

1 reference

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CCR5- and CXCR4-tropic HIV-1 are equally cytopathic for their T-cell targets in human lymphoid tissue.

1 reference

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7 January 2021

Human immunodeficiency virus type 1 induces apoptosis in CD4(+) but not in CD8(+) T cells in ex vivo-infected human lymphoid tissue

1 reference

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Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy

1 reference

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JNK/SAPK activity contributes to TRAIL-induced apoptosis

1 reference

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7 January 2021

Distinct mechanisms of CD4+ and CD8+ T-cell activation and bystander apoptosis induced by human immunodeficiency virus type 1 virions

1 reference

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Requirement of Both the Second and Third BIR Domains for the Relief of X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Caspase Inhibition by Smac

1 reference

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Generation of functional thymocytes in the human adult.

1 reference

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In vivo evolution of human immunodeficiency virus type 1 toward increased pathogenicity through CXCR4-mediated killing of uninfected CD4 T cells

1 reference

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Distinct Mechanisms of T Cell Reconstitution Can Be Identified by Estimating Thymic Volume in Adult HIV‐1 Disease

1 reference

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Early Progression of Disease in HIV-Infected Infants with Thymus Dysfunction

1 reference

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Mitochondrial complex I activity is impaired during HIV-1-induced T-cell apoptosis

1 reference

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Defective thymocyte apoptosis and accelerated autoimmune diseases in TRAIL-/- mice

1 reference

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Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77)

1 reference

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Cytopathic killing of peripheral blood CD4(+) T lymphocytes by human immunodeficiency virus type 1 appears necrotic rather than apoptotic and does not require env.

1 reference

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The Pro-451 to Leu polymorphism within the C-terminal tail of P2X7 receptor impairs cell death but not phospholipase D activation in murine thymocytes

1 reference

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Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3.

1 reference

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Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

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The glucocorticoid-induced gene tdag8 encodes a pro-apoptotic G protein-coupled receptor whose activation promotes glucocorticoid-induced apoptosis

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The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function

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Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding

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Critical contribution of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) to apoptosis of human CD4+ T cells in HIV-1-infected hu-PBL-NOD-SCID mice

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Tumor necrosis factor-related apoptosis-inducing ligand induces neuronal death in a murine model of HIV central nervous system infection

1 reference

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Thymic dysfunction and time of infection predict mortality in human immunodeficiency virus-infected infants. CDC Perinatal AIDS Collaborative Transmission Study Group

1 reference

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Effects of IL-7 on early human thymocyte progenitor cells in vitro and in SCID-hu Thy/Liv mice

1 reference

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Impaired progenitor cell function in HIV-negative infants of HIV-positive mothers results in decreased thymic output and low CD4 counts

1 reference

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Effects of exogenous interleukin-7 on human thymus function

1 reference

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Human T lymphopoiesis. In vitro and in vivo study models.

1 reference

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Direct evidence for thymic function in adult humans

1 reference

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Caspase-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis

1 reference

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7 January 2021

Disruption of mitochondrial function during apoptosis is mediated by caspase cleavage of the p75 subunit of complex I of the electron transport chain

1 reference

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The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes

1 reference

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7 January 2021

Selective thymocyte depletion in neonatal HIV-1 thymic infection

1 reference

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JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development.

1 reference

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Collagen deposition in HIV-1 infected lymphatic tissues and T cell homeostasis

1 reference

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Caspase inhibition activates HIV in latently infected cells. Role of tumor necrosis factor receptor 1 and CD95.

1 reference

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Pathogenesis of primary R5 human immunodeficiency virus type 1 clones in SCID-hu mice

1 reference

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Selection of the T cell repertoire.

1 reference

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Induction of orphan nuclear receptor Nur77 gene expression and its role in cadmium-induced apoptosis in lung

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Epitope-tagging approach to determine the stoichiometry of the structural and nonstructural proteins in the virus particles: amount of Vpr in relation to Gag in HIV-1.

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7 January 2021

Development of alphabeta T cells in the human thymus

1 reference

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Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse

1 reference

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7 January 2021

HIV-1-induced thymocyte depletion is associated with indirect cytopathicity and infection of progenitor cells in vivo

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Expression and function of chemokine receptors on human thymocytes: implications for infection by human immunodeficiency virus type 1.

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Critical function of T cell death-associated gene 8 in glucocorticoid-induced thymocyte apoptosis

1 reference

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Early immune reconstitution after potent antiretroviral therapy in HIV-infected children correlates with the increase in thymus volume

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The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression

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Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.

1 reference

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Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomas

1 reference

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BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

1 reference

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7 January 2021

Preferential apoptosis of HIV-1-specific CD4+ T cells

1 reference

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HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure

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Kinetics of CD4+ T cell repopulation of lymphoid tissues after treatment of HIV-1 infection

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Inhibition of Nur77/Nurr1 leads to inefficient clonal deletion of self-reactive T cells

1 reference

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Human immunodeficiency virus inhibits multilineage hematopoiesis in vivo

1 reference

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based on heuristic

inferred from DOI database lookup

Inactivation of human immunodeficiency virus type 1 infectivity with preservation of conformational and functional integrity of virion surface proteins.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/J.VIROL.2006.04.037

1 reference

Europe PubMed Central

PubMed publication ID

7 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

7 September 2017

ResearchGate publication ID

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