(Q38961023)

20 February 2018

review article

1 reference

title

Hypomethylating agent combination strategies in myelodysplastic syndromes: hopes and shortcomings (English)

1 reference

20 February 2018

author

Thomas Prebet

series ordinal

4

1 reference

PubMed publication ID

8 September 2017

Brian Ball

1

1 reference

20 February 2018

Amer Zeidan

series ordinal

2

1 reference

20 February 2018

Steven D Gore

series ordinal

3

1 reference

20 February 2018

publication date

21 September 2016

1 reference

20 February 2018

published in

Leukemia & Lymphoma

1 reference

20 February 2018

volume

58

1 reference

20 February 2018

issue

5

1 reference

20 February 2018

page(s)

1022-1036

1 reference

20 February 2018

A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling

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17 June 2018

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A phase II study of decitabine and gemtuzumab ozogamicin in newly diagnosed and relapsed acute myeloid leukemia and high-risk myelodysplastic syndrome.

17 June 2018

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Safety and tolerability of guadecitabine (SGI-110) in patients with myelodysplastic syndrome and acute myeloid leukaemia: a multicentre, randomised, dose-escalation phase 1 study

17 June 2018

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Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.

17 June 2018

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17 June 2018

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17 June 2018

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Sonic hedgehog produced by bone marrow-derived mesenchymal stromal cells supports cell survival in myelodysplastic syndrome

17 June 2018

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Hypomethylation and up-regulation of PD-1 in T cells by azacytidine in MDS/AML patients: A rationale for combined targeting of PD-1 and DNA methylation

17 June 2018

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Thrombopoiesis-stimulating agents and myelodysplastic syndromes

17 June 2018

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Phase I/II trial of the combination of midostaurin (PKC412) and 5-azacytidine for patients with acute myeloid leukemia and myelodysplastic syndrome

17 June 2018

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Some aspects of allogeneic stem cell transplantation in patients with myelodysplastic syndrome: advances and controversy

17 June 2018

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Results of phase 2 randomized study of low-dose decitabine with or without valproic acid in patients with myelodysplastic syndrome and acute myelogenous leukemia

17 June 2018

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Prognostic value of isocitrate dehydrogenase mutations in myelodysplastic syndromes: a retrospective cohort study and meta-analysis

17 June 2018

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A pilot phase I dose finding safety study of the thrombopoietin-receptor agonist, eltrombopag, in patients with myelodysplastic syndrome treated with azacitidine

17 June 2018

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The past and future of CD33 as therapeutic target in acute myeloid leukemia.

17 June 2018

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Results of a randomized, double-blind study of romiplostim versus placebo in patients with low/intermediate-1-risk myelodysplastic syndrome and thrombocytopenia

17 June 2018

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Prolonged administration of azacitidine with or without entinostat for myelodysplastic syndrome and acute myeloid leukemia with myelodysplasia-related changes: results of the US Leukemia Intergroup trial E1905.

17 June 2018

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Limited clinical efficacy of azacitidine in transfusion-dependent, growth factor-resistant, low- and Int-1-risk MDS: Results from the nordic NMDSG08A phase II trial

17 June 2018

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Synergistic targeting of AML stem/progenitor cells with IAP antagonist birinapant and demethylating agents

17 June 2018

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Inhibitor of Apoptosis (IAP) proteins in hematological malignancies: molecular mechanisms and therapeutic opportunities

17 June 2018

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Dual epigenetic targeting with panobinostat and azacitidine in acute myeloid leukemia and high-risk myelodysplastic syndrome

17 June 2018

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New and emerging HDAC inhibitors for cancer treatment

17 June 2018

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Expression of PD-L1, PD-L2, PD-1 and CTLA4 in myelodysplastic syndromes is enhanced by treatment with hypomethylating agents.

17 June 2018

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Clinical and biological implications of driver mutations in myelodysplastic syndromes

17 June 2018

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Smac mimetic and demethylating agents synergistically trigger cell death in acute myeloid leukemia cells and overcome apoptosis resistance by inducing necroptosis

17 June 2018

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Isocitrate dehydrogenase mutations in leukemia

17 June 2018

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Current therapy of myelodysplastic syndromes

17 June 2018

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Epigenetics in focus: pathogenesis of myelodysplastic syndromes and the role of hypomethylating agents.

17 June 2018

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(R)-2-hydroxyglutarate is sufficient to promote leukemogenesis and its effects are reversible

17 June 2018

1 reference

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Myelodysplastic syndromes: who and when in the course of disease to transplant

17 June 2018

1 reference

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Phase 2 study of the lenalidomide and azacitidine combination in patients with higher-risk myelodysplastic syndromes

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5785935

A randomized controlled trial of romiplostim in patients with low- or intermediate-risk myelodysplastic syndrome receiving decitabine

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5785935

Revised international prognostic scoring system for myelodysplastic syndromes

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5785935

New comprehensive cytogenetic scoring system for primary myelodysplastic syndromes (MDS) and oligoblastic acute myeloid leukemia after MDS derived from an international database merge

17 June 2018

1 reference

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Cancer-testis antigen expression and its epigenetic modulation in acute myeloid leukemia

17 June 2018

1 reference

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Outcome of high-risk myelodysplastic syndrome after azacitidine treatment failure

17 June 2018

1 reference

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Impact of the degree of anemia on the outcome of patients with myelodysplastic syndrome and its integration into the WHO classification-based Prognostic Scoring System (WPSS)

17 June 2018

1 reference

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Incidence of the myelodysplastic syndromes using a novel claims-based algorithm: high number of uncaptured cases by cancer registries.

17 June 2018

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Hallmarks of Cancer: The Next Generation

17 June 2018

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Phase 2 clinical trial of 5-azacitidine, valproic acid, and all-trans retinoic acid in patients with high-risk acute myeloid leukemia or myelodysplastic syndrome

17 June 2018

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Vorinostat in acute myeloid leukemia and myelodysplastic syndromes

17 June 2018

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

17 June 2018

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Phase 2 study of romiplostim in patients with low- or intermediate-risk myelodysplastic syndrome receiving azacitidine therapy

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5785935

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

17 June 2018

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A comparison of azacitidine and decitabine activities in acute myeloid leukemia cell lines

17 June 2018

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Gli1 regulates the proliferation and differentiation of HSCs and myeloid progenitors.

17 June 2018

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Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia

17 June 2018

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Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study

17 June 2018

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Acetylation of non-histone proteins modulates cellular signalling at multiple levels

17 June 2018

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Phase 2, single-arm trial to evaluate the effectiveness of darbepoetin alfa for correcting anaemia in patients with myelodysplastic syndromes

17 June 2018

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Histone deacetylase inhibitors: mechanisms of cell death and promise in combination cancer therapy

17 June 2018

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IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis

17 June 2018

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17 June 2018

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Phase 2 study of lenalidomide in transfusion-dependent, low-risk, and intermediate-1 risk myelodysplastic syndromes with karyotypes other than deletion 5q.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5785935

Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5785935

Phase 1/2 study of the combination of 5-aza-2'-deoxycytidine with valproic acid in patients with leukemia

17 June 2018

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Decitabine improves patient outcomes in myelodysplastic syndromes: results of a phase III randomized study

17 June 2018

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Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia

17 June 2018

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5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy

17 June 2018

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Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B.

17 June 2018

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Histone acetylation: a switch between repressive and permissive chromatin. Second in review series on chromatin dynamics.

17 June 2018

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Efficacy and safety of gemtuzumab ozogamicin in patients with CD33-positive acute myeloid leukemia in first relapse

17 June 2018

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Structural basis of IAP recognition by Smac/DIABLO

17 June 2018

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Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

17 June 2018

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Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias

17 June 2018

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Randomized Phase II Study of Azacitidine Alone or in Combination With Lenalidomide or With Vorinostat in Higher-Risk Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia: North American Intergroup Study SWOG S1117.

17 June 2018

1 reference

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Validation of WHO classification-based Prognostic Scoring System (WPSS) for myelodysplastic syndromes and comparison with the revised International Prognostic Scoring System (IPSS-R). A study of the International Working Group for Prognosis in Myelo

21 August 2018

1 reference

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Presence of isocitrate dehydrogenase mutations may predict clinical response to hypomethylating agents in patients with acute myeloid leukemia.

21 August 2018

1 reference

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A phase 1 clinical trial of vorinostat in combination with decitabine in patients with acute myeloid leukaemia or myelodysplastic syndrome.

21 August 2018

1 reference

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SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML.

21 August 2018

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Prospective phase II Study on 5-days azacitidine for treatment of symptomatic and/or erythropoietin unresponsive patients with low/INT-1-risk myelodysplastic syndromes

21 August 2018

1 reference

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High response rate and improved exercise capacity and quality of life with a new regimen of darbepoetin alfa with or without filgrastim in lower-risk myelodysplastic syndromes: a phase II study by the GFM.

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5785935

Sequential combination of azacitidine and lenalidomide in del(5q) higher-risk myelodysplastic syndromes or acute myeloid leukemia: a phase I study

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5785935

Azacitidine fails to eradicate leukemic stem/progenitor cell populations in patients with acute myeloid leukemia and myelodysplasia

21 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5785935

Clinical, morphological, cytogenetic, and prognostic features of patients with myelodysplastic syndromes and del(5q) including band q31

21 August 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5785935

The value of allogeneic and autologous hematopoietic stem cell transplantation in prognostically favorable acute myeloid leukemia with double mutant CEBPA.

21 August 2018

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Monoclonal B-cell lymphocytosis and early-stage chronic lymphocytic leukemia: diagnosis, natural history, and risk stratification

21 January 2018

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Clinical application and proposal for modification of the International Working Group (IWG) response criteria in myelodysplasia

21 January 2018

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Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms

21 January 2018

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12 December 2020

Differences in CD33 intensity between various myeloid neoplasms

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12 December 2020

Does addition of erythropoiesis stimulating agents improve the outcome of higher-risk myelodysplastic syndromes treated with azacitidine?

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12 December 2020

Myelodysplastic syndromes

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12 December 2020

Antitumor activity and novel DNA-self-strand-breaking mechanism of CNDAC (1-(2-C-cyano-2-deoxy-beta-D-arabino-pentofuranosyl) cytosine) and its N4-palmitoyl derivative (CS-682)

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12 December 2020

XIAP expression correlates with monocytic differentiation in adult de novo AML: impact on prognosis

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12 December 2020

Impact of TET2 mutations on response rate to azacitidine in myelodysplastic syndromes and low blast count acute myeloid leukemias

1 reference

12 December 2020

Addition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II study

1 reference

12 December 2020

10.1080/10428194.2016.1228927

Identifiers

DOI

1 reference

20 February 2018

PMC publication ID

5785935

1 reference

20 February 2018

PubMed publication ID

27654579

1 reference

20 February 2018