(Q38970938)

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Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069801%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069801%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

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based on heuristic

inferred from title

object named as

amiodarone

15 June 2024

11

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069801%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

author name string

Yun-Ping Lim

1

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10 March 2020

Ching-Hao Cheng

2

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10 March 2020

Wei-Cheng Chen

3

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10 March 2020

Shih-Yu Chang

4

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10 March 2020

Dong-Zong Hung

5

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10 March 2020

Jih-Jung Chen

6

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10 March 2020

Lei Wan

7

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10 March 2020

Wei-Chih Ma

8

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10 March 2020

Yu-Hsien Lin

9

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10 March 2020

Cing-Yu Chen

10

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10 March 2020

Miki Nakajima

12

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10 March 2020

Chao-Jung Chen

13

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10 March 2020

publication date

29 July 2014

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10 March 2020

Archives of Toxicology

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069801%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

89

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10 March 2020

1

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10 March 2020

57-72

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10 March 2020

Endogenous gene and protein expression of drug-transporting proteins in cell lines routinely used in drug discovery programs

1 reference

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21 January 2018

In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulation

1 reference

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21 January 2018

Plasma glutathione S-transferase measurements after paracetamol overdose: evidence for early hepatocellular damage

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

1 reference

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21 January 2018

Mitochondrial abnormalities--a link to idiosyncratic drug hepatotoxicity?

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

The disposition of allyl isothiocyanate in the rat and mouse.

1 reference

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21 January 2018

Overcoming drug resistance by regulating nuclear receptors

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

A single amino acid controls the functional switch of human constitutive androstane receptor (CAR) 1 to the xenobiotic-sensitive splicing variant CAR3.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Camptothecin attenuates cytochrome P450 3A4 induction by blocking the activation of human pregnane X receptor

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Nuclear receptors in the multidrug resistance through the regulation of drug-metabolizing enzymes and drug transporters.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Pregnane X receptor as a target for treatment of inflammatory bowel disorders

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Induction of drug-metabolizing enzymes: a path to the discovery of multiple cytochromes P450

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

N-acetyl-p-benzoquinone imine: a cytochrome P-450-mediated oxidation product of acetaminophen

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Targeting xenobiotic receptors PXR and CAR for metabolic diseases

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Cytochrome p450 and chemical toxicology

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Applying mechanisms of chemical toxicity to predict drug safety

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Enhanced acetaminophen toxicity by activation of the pregnane X receptor

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Identification and quantitation of novel metabolites of amiodarone in plasma of treated patients

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

A human immunodeficiency virus protease inhibitor is a novel functional inhibitor of human pregnane X receptor

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

An in vitro drug-induced hepatotoxicity screening system using CYP3A4-expressing and gamma-glutamylcysteine synthetase knockdown cells.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

A mechanistic study on altered pharmacokinetics of irinotecan by St. John's wort.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Induction of human CYP2A6 is mediated by the pregnane X receptor with peroxisome proliferator-activated receptor-gamma coactivator 1alpha.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR).

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Acetaminophen-induced hepatotoxicity

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Metabolism of sinigrin (2-propenyl glucosinolate) by the human colonic microflora in a dynamic in vitro large-intestinal model.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Fucoxanthin attenuates rifampin-induced cytochrome P450 3A4 (CYP3A4) and multiple drug resistance 1 (MDR1) gene expression through pregnane X receptor (PXR)-mediated pathways in human hepatoma HepG2 and colon adenocarcinoma LS174T cells

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

A dual function of the furanocoumarin chalepensin in inhibiting Cyp2a and inducing Cyp2b in mice: the protein stabilization and receptor-mediated activation

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Effects of allyl isothiocyanate from horseradish on several experimental gastric lesions in rats

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Disruption of hepatic lipid homeostasis in mice after amiodarone treatment is associated with peroxisome proliferator-activated receptor-alpha target gene activation

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expression profile.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Selective induction of phase II enzymes in the urinary bladder of rats by allyl isothiocyanate, a compound derived from Brassica vegetables

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Inhibition of fungal growth on bread by volatile components from spices and herbs, and the possible application in active packaging, with special emphasis on mustard essential oil.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Pregnane X receptor mediates the induction of P-glycoprotein by spironolactone in HepG2 cells.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Cytochrome P450 expression in human hepatocytes and hepatoma cell lines: molecular mechanisms that determine lower expression in cultured cells

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Nuclear receptors as drug targets for metabolic disease

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Bactericidal activity of wasabi (Wasabia japonica) against Helicobacter pylori

1 reference

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21 January 2018

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

1 reference

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21 January 2018

Comparison of isothiocyanate yield from wasabi rhizome tissues grown in soil or water

1 reference

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21 January 2018

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

1 reference

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21 January 2018

Lower expression of HNF4α and PGC1α might impair rifampicin-mediated CYP3A4 induction under conditions where PXR is overexpressed in human fetal liver cells.

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Anti-inflammatory potential of allyl-isothiocyanate--role of Nrf2, NF-(κ) B and microRNA-155.

1 reference

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21 January 2018

The effect of aprepitant and race on the pharmacokinetics of cyclophosphamide in breast cancer patients

1 reference

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21 January 2018

CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme

1 reference

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21 January 2018

Glucocorticoid receptor enhancement of pregnane X receptor-mediated CYP2B6 regulation in primary human hepatocytes

1 reference

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21 January 2018

Activated pregnenolone X-receptor is a target for ketoconazole and its analogs.

1 reference

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21 January 2018

The phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane X receptor

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

Pregnane X receptor activation induces FGF19-dependent tumor aggressiveness in humans and mice

1 reference

https://api.crossref.org/works/10.1007%2FS00204-014-1230-X

21 January 2018

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

1 reference

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21 January 2018

Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits proliferation of human prostate cancer cells by causing G2/M arrest and inducing apoptosis

1 reference

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21 January 2018

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

1 reference

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21 January 2018

Evaluation of cytochrome P450 inhibition assays using human liver microsomes by a cassette analysis /LC-MS/MS.

1 reference

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21 January 2018

Role of glutathione in the accumulation of anticarcinogenic isothiocyanates and their glutathione conjugates by murine hepatoma cells.

1 reference

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21 January 2018

Allyl isothiocyanate as a cancer chemopreventive phytochemical.

1 reference

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21 January 2018

Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR

1 reference

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21 January 2018

The dietary isothiocyanate sulforaphane is an antagonist of the human steroid and xenobiotic nuclear receptor.

1 reference

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21 January 2018

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10.1007/S00204-014-1230-X

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069801%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

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1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25069801%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

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