(Q38972039)

8 September 2017

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title

Recent advances in targeting the fatty acid biosynthetic pathway using fatty acid synthase inhibitors (English)

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8 September 2017

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Thelma S Angeles

1

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8 September 2017

Robert L Hudkins

series ordinal

2

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8 September 2017

language of work or name

English

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publication date

5 October 2016

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Expert Opinion on Drug Discovery

8 September 2017

published in

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8 September 2017

volume

11

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8 September 2017

issue

12

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8 September 2017

page(s)

1187-1199

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Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis

8 September 2017

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Fatty acid synthase as a potential therapeutic target in cancer

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The multienzyme architecture of eukaryotic fatty acid synthases

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Structure and function of animal fatty acid synthase

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Mammalian fatty acid synthase: X-ray structure of a molecular assembly line

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Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer: uptake of radiolabeled acetate as a predictor of the targeted therapy outcome

21 January 2018

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Targeted therapy with fatty acid synthase inhibitors in a human prostate carcinoma LNCaP/tk-luc-bearing animal model

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Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer

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Selective inhibition of fatty acid synthase for lung cancer treatment

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Fatty acid synthase expression in osteosarcoma and its correlation with pulmonary metastasis

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Blockade of fatty acid synthase triggers significant apoptosis in mantle cell lymphoma

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Metabolic intervention on lipid synthesis converging pathways abrogates prostate cancer growth

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Fatty acid synthase inhibitors cerulenin and C75 retard growth and induce caspase-dependent apoptosis in human melanoma A-375 cells

21 January 2018

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Mechanisms of obesity-induced gastrointestinal neoplasia

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Comparative study of the lipogenic potential of human and rat adipose tissue

21 January 2018

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Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARγ activation to decrease diet-induced obesity

21 January 2018

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Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides

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Sensing the fat: fatty acid metabolism in the hypothalamus and the melanocortin system

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Progress in the development of fatty acid synthase inhibitors as anticancer targets

21 January 2018

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Anti-cancer drugs targeting fatty acid synthase (FAS).

21 January 2018

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Discovery of GSK837149A, an inhibitor of human fatty acid synthase targeting the beta-ketoacyl reductase reaction

21 January 2018

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New synthetic inhibitors of fatty acid synthase with anticancer activity

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Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Crystal structure of the thioesterase domain of human fatty acid synthase inhibited by Orlistat

21 January 2018

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Synthesis of novel beta-lactone inhibitors of fatty acid synthase

21 January 2018

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Inhibition of fatty acid synthase by polyphenols

21 January 2018

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21 January 2018

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21 January 2018

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The galloyl moiety of green tea catechins is the critical structural feature to inhibit fatty-acid synthase

21 January 2018

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Therapeutic potential of resveratrol: the in vivo evidence

21 January 2018

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The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2016.1245286

Triclosan: a critical review of the experimental data and development of margins of safety for consumer products

21 January 2018

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Fatty acid synthase is a potential molecular target for the chemoprevention of breast cancer

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2016.1245286

Triclosan inhibits enoyl-reductase of type I fatty acid synthase in vitro and is cytotoxic to MCF-7 and SKBr-3 breast cancer cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2016.1245286

Curcumin inhibits intracellular fatty acid synthase and induces apoptosis in human breast cancer MDA-MB-231 cells

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2016.1245286

Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells

21 January 2018

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Platensimycin, a new antibiotic and "superbug challenger" from nature

21 January 2018

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Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2016.1245286

The crystal structure of a mammalian fatty acid synthase

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2016.1245286

Virtual screening, molecular dynamics, and binding free energy calculations on human carbonic anhydrase IX catalytic domain for deciphering potential leads

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2016.1245286

A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2016.1245286

Multivariate SAR/QSAR of 3-aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase (FAS) inhibitors.

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2016.1245286

You Lose Some, You Win Some: Weight Loss Induces Microbiota and Metabolite Shifts

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2016.1245286

Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2016.1245286

Fatty Acid synthase inhibitors as possible treatment for cancer: patent highlight

21 January 2018

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https://api.crossref.org/works/10.1080%2F17460441.2016.1245286

Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F17460441.2016.1245286

10.1080/17460441.2016.1245286

21 January 2018

Identifiers

DOI

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8 September 2017

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