(Q38995566)

English

In vitro experimental system for evaluating inhibitory effect of investigational drugs on P-glycoprotein-mediated transcellular transport of tacrolimus (FK506).

scientific article published on April 2014

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scholarly article

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Europe PubMed Central

PubMed publication ID

8 September 2017

In vitro experimental system for evaluating inhibitory effect of investigational drugs on P-glycoprotein-mediated transcellular transport of tacrolimus (FK506). (English)

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

author name string

Kazuo Oda

1

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Europe PubMed Central

PubMed publication ID

8 September 2017

Hiroyuki Nemoto

2

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Europe PubMed Central

PubMed publication ID

8 September 2017

Yasuhisa Nagasaka

3

1 reference

Europe PubMed Central

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8 September 2017

Akio Kawamura

4

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Europe PubMed Central

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8 September 2017

Takashi Usui

5

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Europe PubMed Central

PubMed publication ID

8 September 2017

publication date

1 April 2014

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8 September 2017

Biopharmaceutics and Drug Disposition

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Europe PubMed Central

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8 September 2017

35

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Europe PubMed Central

PubMed publication ID

8 September 2017

3

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Europe PubMed Central

PubMed publication ID

8 September 2017

135-144

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Europe PubMed Central

PubMed publication ID

8 September 2017

Biochemistry of multidrug resistance mediated by the multidrug transporter

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Increased drug delivery to the brain by P-glycoprotein inhibition

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Can the enhanced renal clearance of antibiotics in cystic fibrosis patients be explained by P-glycoprotein transport?

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Metabolism of tacrolimus (FK506) and recent topics in clinical pharmacokinetics

1 reference

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Impact of MDR1 and CYP3A5 on the oral clearance of tacrolimus and tacrolimus-related renal dysfunction in adult living-donor liver transplant patients

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Intestinal MDR1/ABCB1 level at surgery as a risk factor of acute cellular rejection in living-donor liver transplant patients

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Initial dosage adjustment for oral administration of tacrolimus using the intestinal MDR1 level in living-donor liver transplant recipients

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Tacrolimus therapy according to mucosal MDR1 levels in small-bowel transplant recipients

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The enzymatic basis of drug-drug interactions with systemic triazole antifungals.

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Membrane transporters in drug development

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Stimulation of P-glycoprotein-mediated drug transport by prazosin and progesterone. Evidence for a third drug-binding site.

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Functional assessment of multiple P-glycoprotein (P-gp) probe substrates: influence of cell line and modulator concentration on P-gp activity

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Interrelationship between substrates and inhibitors of human CYP3A and P-glycoprotein.

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Tacrolimus is a class II low-solubility high-permeability drug: the effect of P-glycoprotein efflux on regional permeability of tacrolimus in rats

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Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein

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P-glycoprotein-dependent disposition kinetics of tacrolimus: studies in mdr1a knockout mice

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Predicting P-glycoprotein effects on oral absorption: correlation of transport in Caco-2 with drug pharmacokinetics in wild-type and mdr1a(-/-) mice in vivo.

1 reference

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21 January 2018

Variability in mRNA expression of ABC- and SLC-transporters in human intestinal cells: comparison between human segments and Caco-2 cells.

1 reference

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21 January 2018

Identifiers

10.1002/BDD.1876

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 September 2017

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